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Research Article
Hyun-Min Seo
Hanyang University Guri Hospital, Hanyang University
Corresponding Author
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Objective
This study aimed to evaluate the causal relationship between long-term outdoor air pollutants and incidence of peripheral arterial disease (PAD) using the National Health Insurance Service–National Sample Cohort (NHIS-NSC) database.
Methods
This study is retrospective study. We included 292,091 subjects from the general population who had previously not been diagnosed with PAD by the NHIS-NSC between 2008 and 2014. Hourly air pollutant data (particulate and gaseous) and climate data were collected. Correlation analysis of the collected data confirmed the relationship between air pollution and PAD incidence.
Results
For 1,836,965.4 person-years, incident cases of PAD were observed in 5,243 subjects (285.4/100,000 person-years). In the Cox proportional hazard analysis, there was a significant association between the incidence of PAD and long-term average concentration of SO2 (hazard ratio [HR], 1.686; 95% confidence interval [CI], 1.108–2.565) and NO2 (HR, 1.200; 95% CI, 1.077–1.336) after the adjustment for variables.
Conclusions
This study demonstrated that SO2 and NO2 exposure are independent risk factors for PAD. On the other hand, new-onset PAD was not affected by exposure to particulate matter such as PM2.5 and PM10.
Keywords
air pollution, nitrogen dioxide, particulate matter, peripheral arterial disease, sulfur dioxide
Figure 1
No competing interests reported.
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A new preprint design is coming!
We have improved readability, clarity, accessibility, and opportunities for engagement.
This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Research Article
Hyun-Min Seo
Hanyang University Guri Hospital, Hanyang University
Corresponding Author
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
History
CURRENT STATUS: Posted
Version 1
Posted 13 May, 2021
No community comments so far
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Objective
This study aimed to evaluate the causal relationship between long-term outdoor air pollutants and incidence of peripheral arterial disease (PAD) using the National Health Insurance Service–National Sample Cohort (NHIS-NSC) database.
Methods
This study is retrospective study. We included 292,091 subjects from the general population who had previously not been diagnosed with PAD by the NHIS-NSC between 2008 and 2014. Hourly air pollutant data (particulate and gaseous) and climate data were collected. Correlation analysis of the collected data confirmed the relationship between air pollution and PAD incidence.
Results
For 1,836,965.4 person-years, incident cases of PAD were observed in 5,243 subjects (285.4/100,000 person-years). In the Cox proportional hazard analysis, there was a significant association between the incidence of PAD and long-term average concentration of SO2 (hazard ratio [HR], 1.686; 95% confidence interval [CI], 1.108–2.565) and NO2 (HR, 1.200; 95% CI, 1.077–1.336) after the adjustment for variables.
Conclusions
This study demonstrated that SO2 and NO2 exposure are independent risk factors for PAD. On the other hand, new-onset PAD was not affected by exposure to particulate matter such as PM2.5 and PM10.
Figure 1
No competing interests reported.
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