This preprint is under consideration at World Journal of Surgical Oncology. A preprint is a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
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Research Article
Irénée Niyongombwa
Byumba District Hospital
Corresponding Author
ORCiD: https://orcid.org/0000-0003-2146-742X
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Purpose:
Gastric cancer is endemic in the so called stomach cancer region comprising Rwanda, Burundi, South Western Uganda and eastern Kivu province of Democratic Republic of Congo but its outcomes in that region are under investigated. This is the first study ever conducted in Rwanda with the purpose to describe the short term outcomes (in-hospital mortality rate, length of hospital stay, 3, 6, 12 and 24 months survival rates) in patients treated for gastric cancer.
Methods:
We retrospectively reviewed the data collected from records of patients who consulted CHUK over a period of 10 years from September 2007 to August 2016. Patients were followed in hospital and after discharge for survival length. Descriptive statistics were used for baseline demographic data, Kaplan-Meier model and univariate cox regression were used for survival analysis.
Results:
Of the 199 patients enrolled in the study, 92 (46%) were males and 107 (54%) females. The mean age was 55.4 ranging between 24 and 93. The mean symptoms duration was 15 months. Most patients consulted with advanced disease, 62.3% with distant metastases. Treatment with curative intent was offered for only 19.9% of patients. The in-hospital mortality rate was 13.3%. The 3, 6, 12 and 24 months survival rate was 52%, 40.5%, 28% and 23.4% respectively. The Overall survival rate was 7 months.
Conclusion:
In Rwanda, patients with gastric cancer have delayed consultations and advanced disease at the time of presentation. This cancer is associated with poor outcomes in terms of hospital mortality and post discharge survival rates.
Keywords
Cancer, stomach, outcomes, survival, low and middle income countries
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Peer Review Timeline
CURRENT STATUS: Under Review
Version 2
Posted 19 Mar, 2021
No community comments so far
Editorial decision: Major revision
On 11 Apr, 2021
Reviews received
Received 18 Mar, 2021
Editor assigned
On 16 Mar, 2021
Reviewers invited
Invitations sent on 16 Mar, 2021
First submitted
On 14 Mar, 2021
No comments provided
Editorial decision: Reject after peer review
On 24 Aug, 2020
Review #2 received
Received 23 Aug, 2020
Reviewer #2 agreed
On 10 Aug, 2020
Reviewer #1 agreed
On 02 Aug, 2020
Review #1 received
Received 02 Aug, 2020
Reviewers invited
Invitations sent on 01 Aug, 2020
Editor assigned
On 30 Jul, 2020
First submitted
On 29 Jul, 2020
Submission checks complete
On 29 Jul, 2020
Editor invited
On 29 Jul, 2020
Metrics
Comments: 0
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This preprint is under consideration at World Journal of Surgical Oncology. A preprint is a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research Article
Irénée Niyongombwa
Byumba District Hospital
Corresponding Author
ORCiD: https://orcid.org/0000-0003-2146-742X
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Under Review
Version 2
Posted 19 Mar, 2021
No community comments so far
Editorial decision: Major revision
On 11 Apr, 2021
Reviews received
Received 18 Mar, 2021
Editor assigned
On 16 Mar, 2021
Reviewers invited
Invitations sent on 16 Mar, 2021
First submitted
On 14 Mar, 2021
No comments provided
Editorial decision: Reject after peer review
On 24 Aug, 2020
Review #2 received
Received 23 Aug, 2020
Reviewer #2 agreed
On 10 Aug, 2020
Reviewer #1 agreed
On 02 Aug, 2020
Review #1 received
Received 02 Aug, 2020
Reviewers invited
Invitations sent on 01 Aug, 2020
Editor assigned
On 30 Jul, 2020
First submitted
On 29 Jul, 2020
Submission checks complete
On 29 Jul, 2020
Editor invited
On 29 Jul, 2020
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Purpose:
Gastric cancer is endemic in the so called stomach cancer region comprising Rwanda, Burundi, South Western Uganda and eastern Kivu province of Democratic Republic of Congo but its outcomes in that region are under investigated. This is the first study ever conducted in Rwanda with the purpose to describe the short term outcomes (in-hospital mortality rate, length of hospital stay, 3, 6, 12 and 24 months survival rates) in patients treated for gastric cancer.
Methods:
We retrospectively reviewed the data collected from records of patients who consulted CHUK over a period of 10 years from September 2007 to August 2016. Patients were followed in hospital and after discharge for survival length. Descriptive statistics were used for baseline demographic data, Kaplan-Meier model and univariate cox regression were used for survival analysis.
Results:
Of the 199 patients enrolled in the study, 92 (46%) were males and 107 (54%) females. The mean age was 55.4 ranging between 24 and 93. The mean symptoms duration was 15 months. Most patients consulted with advanced disease, 62.3% with distant metastases. Treatment with curative intent was offered for only 19.9% of patients. The in-hospital mortality rate was 13.3%. The 3, 6, 12 and 24 months survival rate was 52%, 40.5%, 28% and 23.4% respectively. The Overall survival rate was 7 months.
Conclusion:
In Rwanda, patients with gastric cancer have delayed consultations and advanced disease at the time of presentation. This cancer is associated with poor outcomes in terms of hospital mortality and post discharge survival rates.
Figure 1
Figure 2
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