This preprint is under consideration at Neurosurgical Review. A preprint is a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
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Research Article
Shuo Wang
Beijing Tiantan Hospital, Capital Medical University
Corresponding Author
ORCiD: https://orcid.org/0000-0003-4919-5390
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Baseline hematoma volume (HV) and hematoma growth (HG) affect the prognosis of spontaneous intracranial hematoma (ICH), but there is still a lack of evidence on the effects of aspirin (acetylsalicylic acid, ASA) on HV and HG in patients with severe ICH. This study retrospectively analyzed patients with severe ICH who met the inclusion and exclusion criterias in Beijing Tiantan Hospital, Capital Medical University between January 1, 2015 and July 31, 2019. Severe ICH patients were divided into ASA group and nASA group according to ASA usage, and the effects of prior ASA on HV and HG were evaluated respectively. And possible risk factors for HG were screened. Totally, 221 patients with severe ICH were consecutively enrolled into this study. There were 72 (32.58%) patients in ASA group and 149 patients (67.42%) in nASA group. Although the baseline HV of the nASA group was significantly higher than that of the ASA group (45.51±29.76 VS 32.67±25.85, p=0.001), after adjusting for confounding factors, the prior ASA did not significantly affect the baseline HV (p = 0.057). Similarly, although the incidence of HG in nASA group was higher than that in ASA group (36.2% VS 25.0%, p = 0.095), ASA did not significantly affect the occurrence of HG (p =0.057). In addition, we found that admission high blood pressure and GCS were risk factors for HG. Prior ASA does not increase the baseline HV and the incidence of HG in severe ICH patients. In addition, admission high blood pressure and GCS were risk factors for HG.
Keywords
Aspirin, Antiplatelet, Intracerebral hemorrhage, Hematoma expansion, Stroke.
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CURRENT STATUS: Under Review
Version 1
Posted 28 May, 2021
No community comments so far
Editorial decision: Major revisions
On 21 Jun, 2021
Reviews received
Received 26 May, 2021
Reviewers invited
Invitations sent on 26 May, 2021
Editor assigned
On 11 May, 2021
First submitted
On 07 May, 2021
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Subject Areas
Neurosurgery
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This preprint is under consideration at Neurosurgical Review. A preprint is a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research Article
Shuo Wang
Beijing Tiantan Hospital, Capital Medical University
Corresponding Author
ORCiD: https://orcid.org/0000-0003-4919-5390
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Under Review
Version 1
Posted 28 May, 2021
No community comments so far
Editorial decision: Major revisions
On 21 Jun, 2021
Reviews received
Received 26 May, 2021
Reviewers invited
Invitations sent on 26 May, 2021
Editor assigned
On 11 May, 2021
First submitted
On 07 May, 2021
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Neurosurgery
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Baseline hematoma volume (HV) and hematoma growth (HG) affect the prognosis of spontaneous intracranial hematoma (ICH), but there is still a lack of evidence on the effects of aspirin (acetylsalicylic acid, ASA) on HV and HG in patients with severe ICH. This study retrospectively analyzed patients with severe ICH who met the inclusion and exclusion criterias in Beijing Tiantan Hospital, Capital Medical University between January 1, 2015 and July 31, 2019. Severe ICH patients were divided into ASA group and nASA group according to ASA usage, and the effects of prior ASA on HV and HG were evaluated respectively. And possible risk factors for HG were screened. Totally, 221 patients with severe ICH were consecutively enrolled into this study. There were 72 (32.58%) patients in ASA group and 149 patients (67.42%) in nASA group. Although the baseline HV of the nASA group was significantly higher than that of the ASA group (45.51±29.76 VS 32.67±25.85, p=0.001), after adjusting for confounding factors, the prior ASA did not significantly affect the baseline HV (p = 0.057). Similarly, although the incidence of HG in nASA group was higher than that in ASA group (36.2% VS 25.0%, p = 0.095), ASA did not significantly affect the occurrence of HG (p =0.057). In addition, we found that admission high blood pressure and GCS were risk factors for HG. Prior ASA does not increase the baseline HV and the incidence of HG in severe ICH patients. In addition, admission high blood pressure and GCS were risk factors for HG.
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