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Alejandra de-la-Torre
Universidad Del Rosario Escuela de Medicina y Ciencias de la Salud
Corresponding Author
ORCiD: https://orcid.org/0000-0003-0684-1989
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Background: Down syndrome (DS) is a chromosomal anomaly that is characterized by an extra chromosome 21. Ophthalmological manifestations have a high prevalence in patients with DS.
Purpose: To review the scientific evidence and estimate the prevalence of ophthalmological manifestations in the pediatric population with DS.
Data Sources: Electronic databases including MEDLINE, Cochrane Library, EMBASE, ScienceDirect, and LILACS.
Study Eligibility Criteria: Published observational studies with available and original data were included. Articles were excluded if the study design was a review, letter to the editor, case report, case series, or systematic review and if the subjects had ophthalmological manifestations secondary to other conditions.
Participants and Interventions: Pediatric and adolescent population with DS and with ophthalmological evaluation.
Study Appraisal and Synthesis Methods: A data collection form was designed in Excel. Five reviewers extracted relevant details about the design and results of each study. The quality of the studies was assessed by applying the tools of systematic reviews of prevalence and incidence of the Joanna Briggs Institute. We calculated the weighted prevalence of ophthalmological manifestations, considering only the studies reporting the measurement of each manifestation.
Results: Twenty-two articles (from 15 countries, published during 1994–2020) were included in the present systematic review. Ocular manifestations were observed in 85% of the studied pediatric and adolescent populations with DS. The most frequent ones were slanting fissures, oblique fissures, epicanthus, and epiblepharon.
Conclusion: The ocular manifestations in the pediatric and adolescent population with DS are varied, and some can irreversibly affect visual development. Screening of the pediatric population with DS should be conducted from the first months of age and continued annually.
Systematic Review Registration Number: PROSPERO ID CRD42019127717
Keywords
Down syndrome, Children, Ocular findings, Eye Manifestations, Prevalence, Systematic review.
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CURRENT STATUS: Under Review
Version 1
Posted 02 Jun, 2021
No community comments so far
Editorial decision: Minor revision
On 17 Nov, 2021
Review #2 received
Received 09 Nov, 2021
Review #3 received
Received 09 Nov, 2021
Reviewer #3 agreed
On 27 Oct, 2021
Review #1 received
Received 22 Jul, 2021
Reviewer #2 agreed
On 08 Jul, 2021
Reviews received
Received 06 Jul, 2021
Reviewer #1 agreed
On 06 Jul, 2021
Reviewers invited
Invitations sent on 05 Jul, 2021
Editor assigned
On 27 Jun, 2021
Editor invited
On 27 Jun, 2021
Submission checks complete
On 29 May, 2021
First submitted
On 10 May, 2021
Metrics
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PDF Downloads: ...
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Subject Areas
Ophthalmology
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A new preprint design is coming!
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This preprint is under consideration at Systematic Reviews. A preprint is a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research
Alejandra de-la-Torre
Universidad Del Rosario Escuela de Medicina y Ciencias de la Salud
Corresponding Author
ORCiD: https://orcid.org/0000-0003-0684-1989
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Under Review
Version 1
Posted 02 Jun, 2021
No community comments so far
Editorial decision: Minor revision
On 17 Nov, 2021
Review #2 received
Received 09 Nov, 2021
Review #3 received
Received 09 Nov, 2021
Reviewer #3 agreed
On 27 Oct, 2021
Review #1 received
Received 22 Jul, 2021
Reviewer #2 agreed
On 08 Jul, 2021
Reviews received
Received 06 Jul, 2021
Reviewer #1 agreed
On 06 Jul, 2021
Reviewers invited
Invitations sent on 05 Jul, 2021
Editor assigned
On 27 Jun, 2021
Editor invited
On 27 Jun, 2021
Submission checks complete
On 29 May, 2021
First submitted
On 10 May, 2021
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Ophthalmology
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background: Down syndrome (DS) is a chromosomal anomaly that is characterized by an extra chromosome 21. Ophthalmological manifestations have a high prevalence in patients with DS.
Purpose: To review the scientific evidence and estimate the prevalence of ophthalmological manifestations in the pediatric population with DS.
Data Sources: Electronic databases including MEDLINE, Cochrane Library, EMBASE, ScienceDirect, and LILACS.
Study Eligibility Criteria: Published observational studies with available and original data were included. Articles were excluded if the study design was a review, letter to the editor, case report, case series, or systematic review and if the subjects had ophthalmological manifestations secondary to other conditions.
Participants and Interventions: Pediatric and adolescent population with DS and with ophthalmological evaluation.
Study Appraisal and Synthesis Methods: A data collection form was designed in Excel. Five reviewers extracted relevant details about the design and results of each study. The quality of the studies was assessed by applying the tools of systematic reviews of prevalence and incidence of the Joanna Briggs Institute. We calculated the weighted prevalence of ophthalmological manifestations, considering only the studies reporting the measurement of each manifestation.
Results: Twenty-two articles (from 15 countries, published during 1994–2020) were included in the present systematic review. Ocular manifestations were observed in 85% of the studied pediatric and adolescent populations with DS. The most frequent ones were slanting fissures, oblique fissures, epicanthus, and epiblepharon.
Conclusion: The ocular manifestations in the pediatric and adolescent population with DS are varied, and some can irreversibly affect visual development. Screening of the pediatric population with DS should be conducted from the first months of age and continued annually.
Systematic Review Registration Number: PROSPERO ID CRD42019127717
Figure 1
This is a list of supplementary files associated with this preprint. Click to download.
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