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Research Article
Hapizah Mohd Nawawi
Universiti Teknologi MARA (UiTM)
Corresponding Author
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Background: Coronary artery disease (CAD) is one of the major causes of morbidity and mortality worldwide. Early identification of the coronary risk factors (CRF) among youths assists in determining the high-risk group to develop CAD in later life. In view of the modernised lifestyle, both urban and rural residing youths are thought to be equally exposed to various CRF. This study aimed to describe the common CRF including obesity, dyslipidaemia, hypertension, smoking and family history of premature CAD in Malaysian youths residing in urban and rural areas.
Methods: We recruited 942 Malaysian subjects aged 15–24 years old [(males=257, and urban=555 vs rural=387, (mean age + SD = 20.5 + 2.1 years)] from the community health screening programmes organised in both rural and urban regions throughout Malaysia. Medical history and standardised anthropometric measurements were recorded. Laboratory investigations were obtained for fasting serum lipid profiles and plasma glucose levels.
Results: Youths in the rural were more overweight and obese (49.4% vs 42.7%, p<0.044) and have higher family history of hyperlipidaemia (16.3% vs 11.3%, p<0.036) than youths in the urban areas. Low-density lipoprotein (LDL-c) (2.8 vs 2.7 mmol/L) and total cholesterol (TC) (4.7 vs 4.5 mmol/L) were significantly higher in urban compared to rural youths (p<0.019 and p<0.012). Overall, more youth in this study has CRF rather than not (Has CRF = 67.0% vs No CRF = 33.0%). Significantly more rural youths have at least one CRF compared to urban youths (rural = 71.6% vs urban = 63.8%, p=0.012).
Conclusion: In conclusion, rural youths have significantly higher BMI with higher family history of hyperlipidaemia compared to urban youths. However, urban youths have higher LDL-c and TC levels. Other coronary risk factors are not significantly different between urban and rural youths. CRF were significantly more prevalent among rural compared to urban youths.
Keywords
Coronary risk factors, coronary artery disease, youth, urban, rural
Figure 1
No competing interests reported.
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CURRENT STATUS: Under Review
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This preprint is under consideration at BMC Cardiovascular Disorders. A preprint is a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research Article
Hapizah Mohd Nawawi
Universiti Teknologi MARA (UiTM)
Corresponding Author
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Under Review
Version 1
Posted 24 May, 2021
No community comments so far
Reviews received
Received 26 May, 2021
Reviewers agreed
On 21 May, 2021
Reviewers invited
Invitations sent on 20 May, 2021
Editor assigned
On 19 May, 2021
Editor invited
On 19 May, 2021
Submission checks complete
On 19 May, 2021
First submitted
On 11 May, 2021
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Cardiac & Cardiovascular Systems
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background: Coronary artery disease (CAD) is one of the major causes of morbidity and mortality worldwide. Early identification of the coronary risk factors (CRF) among youths assists in determining the high-risk group to develop CAD in later life. In view of the modernised lifestyle, both urban and rural residing youths are thought to be equally exposed to various CRF. This study aimed to describe the common CRF including obesity, dyslipidaemia, hypertension, smoking and family history of premature CAD in Malaysian youths residing in urban and rural areas.
Methods: We recruited 942 Malaysian subjects aged 15–24 years old [(males=257, and urban=555 vs rural=387, (mean age + SD = 20.5 + 2.1 years)] from the community health screening programmes organised in both rural and urban regions throughout Malaysia. Medical history and standardised anthropometric measurements were recorded. Laboratory investigations were obtained for fasting serum lipid profiles and plasma glucose levels.
Results: Youths in the rural were more overweight and obese (49.4% vs 42.7%, p<0.044) and have higher family history of hyperlipidaemia (16.3% vs 11.3%, p<0.036) than youths in the urban areas. Low-density lipoprotein (LDL-c) (2.8 vs 2.7 mmol/L) and total cholesterol (TC) (4.7 vs 4.5 mmol/L) were significantly higher in urban compared to rural youths (p<0.019 and p<0.012). Overall, more youth in this study has CRF rather than not (Has CRF = 67.0% vs No CRF = 33.0%). Significantly more rural youths have at least one CRF compared to urban youths (rural = 71.6% vs urban = 63.8%, p=0.012).
Conclusion: In conclusion, rural youths have significantly higher BMI with higher family history of hyperlipidaemia compared to urban youths. However, urban youths have higher LDL-c and TC levels. Other coronary risk factors are not significantly different between urban and rural youths. CRF were significantly more prevalent among rural compared to urban youths.
Figure 1
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