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Research Article
Kate Keogh
Animal and Bioscience Research Department, Teagasc Grange
Corresponding Author
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The selection of cattle with enhanced feed efficiency is of paramount importance with regard to reducing feed costs in the beef industry. Global transcriptome profiling was undertaken on liver and skeletal muscle biopsies from Simmental heifers and bulls divergent in residual feed intake (RFI) feed efficiency phenotype, in order to identify genes that may be associated with this trait. We identified 5 genes (adj.p<0.1) to be differentially expressed in skeletal muscle between high and low RFI heifers with all transcripts involved in oxidative phosphorylation and mitochondrial homeostasis. A total of 11 genes (adj.p<0. 1) were differentially expressed in liver tissue between high and low RFI bulls with differentially expressed genes related to amino and nucleotide metabolism as well as endoplasmic reticulum protein processing. No genes were identified as differentially expressed in either heifer liver or bull muscle analyses. Results from this study show a clear effect of gender to the underlying molecular control of RFI in cattle, which may be attributable to differences in the physiological age between heifers and bulls. Despite this we have highlighted a number of genes that may hold potential as molecular biomarkers for RFI cattle.
Keywords
RNA-seq, cattle, residual feed intake
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This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Research Article
Kate Keogh
Animal and Bioscience Research Department, Teagasc Grange
Corresponding Author
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
History
CURRENT STATUS: Posted
Version 2
Posted 17 Dec, 2020
No community comments so far
No comments provided
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Epigenetics & Genomics
License:
This work is licensed under a CC BY 4.0 License. Read Full License
The selection of cattle with enhanced feed efficiency is of paramount importance with regard to reducing feed costs in the beef industry. Global transcriptome profiling was undertaken on liver and skeletal muscle biopsies from Simmental heifers and bulls divergent in residual feed intake (RFI) feed efficiency phenotype, in order to identify genes that may be associated with this trait. We identified 5 genes (adj.p<0.1) to be differentially expressed in skeletal muscle between high and low RFI heifers with all transcripts involved in oxidative phosphorylation and mitochondrial homeostasis. A total of 11 genes (adj.p<0. 1) were differentially expressed in liver tissue between high and low RFI bulls with differentially expressed genes related to amino and nucleotide metabolism as well as endoplasmic reticulum protein processing. No genes were identified as differentially expressed in either heifer liver or bull muscle analyses. Results from this study show a clear effect of gender to the underlying molecular control of RFI in cattle, which may be attributable to differences in the physiological age between heifers and bulls. Despite this we have highlighted a number of genes that may hold potential as molecular biomarkers for RFI cattle.
Figure 1
Figure 2
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