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Original Research Article
Tatsuo Yasumitsu
4-6-1 Hyakunin-cho, Shinjuku-ku, Tokyo, 169-0073, Japan ORCID: 0000-0001-7716-4730
Corresponding Author
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This work is licensed under a CC BY 4.0 License. Read Full License
Background: The present study purpose aims to improve cognitive function at the preclinical stage of dementia and measure real-time brain activity levels in participants wearing an ultracompact brain activity sensor called XB-01.
Methods: Four healthy people (two males and two females) aged 20–50 years involved in the dementia prevention program participated in the study. During the experiment, the participants wore XB-01, which was connected to their iPhone by Bluetooth to collect data. XB-01 data indicating the brain activity (blood flow) during the program was demonstrated by real-time color changes on the connected iPhone to evaluate the results on a 100-point scale. We examined 21 programs in total, including those reported to increase brain activity.
Results: We conducted an analysis of variance for each of the four programs in the upper and lower positions detected to compare brain activity, resulting in finding a main effect of the program, F(7,21) = 4.35, p <.05.
Conclusions: An exercise program including a dual-task with large limb movements was highly effective in increasing brain activity in the dorsolateral prefrontal cortex (DLPFC). Moreover, slightly higher speed, pace, and difficulty level of the program most suitable for participants were more effective. Brain activity increased in the DLPFC during the program and several minutes after its completion. These findings can help develop programs that prevent and improve cognitive function.
Trial Registration: The research ethics committee at PCY, Ltd. Trial Registry, approval number 20-2. Registered 04 January 2020. Retrospectively registered.
Keywords
Dementia, Dorsolateral prefrontal cortex, Program, Exercise, Dual task, Event-related potentials
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A new preprint design is coming!
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This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Original Research Article
Tatsuo Yasumitsu
4-6-1 Hyakunin-cho, Shinjuku-ku, Tokyo, 169-0073, Japan ORCID: 0000-0001-7716-4730
Corresponding Author
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
History
CURRENT STATUS: Posted
Version 1
Posted 19 May, 2021
No community comments so far
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Sports Medicine and Kinesiology
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background: The present study purpose aims to improve cognitive function at the preclinical stage of dementia and measure real-time brain activity levels in participants wearing an ultracompact brain activity sensor called XB-01.
Methods: Four healthy people (two males and two females) aged 20–50 years involved in the dementia prevention program participated in the study. During the experiment, the participants wore XB-01, which was connected to their iPhone by Bluetooth to collect data. XB-01 data indicating the brain activity (blood flow) during the program was demonstrated by real-time color changes on the connected iPhone to evaluate the results on a 100-point scale. We examined 21 programs in total, including those reported to increase brain activity.
Results: We conducted an analysis of variance for each of the four programs in the upper and lower positions detected to compare brain activity, resulting in finding a main effect of the program, F(7,21) = 4.35, p <.05.
Conclusions: An exercise program including a dual-task with large limb movements was highly effective in increasing brain activity in the dorsolateral prefrontal cortex (DLPFC). Moreover, slightly higher speed, pace, and difficulty level of the program most suitable for participants were more effective. Brain activity increased in the DLPFC during the program and several minutes after its completion. These findings can help develop programs that prevent and improve cognitive function.
Trial Registration: The research ethics committee at PCY, Ltd. Trial Registry, approval number 20-2. Registered 04 January 2020. Retrospectively registered.
Figure 1
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