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Article
Junle Qu
Shenzhen University
Corresponding Author
ORCiD: https://orcid.org/0000-0001-7833-4711
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This work is licensed under a CC BY 4.0 License. Read Full License
Metallic and semimetallic mesoporous frameworks are of great importance owing to their unique properties and broad applications. However, semimetallic mesoporous structures cannot be obtained by the traditional template-mediated strategies due to the inevitable hydrolytic reaction of semimetal compounds. Therefore, it is yet challenging to fabricate mesoporous semimetal nanostructures, not even mention controlling their pore sizes. Thus, we have developed a facile and robust selective etching route to synthesize monodispersed mesoporous antimony nanospheres (MSbNSs). This is the first report of semimetallic mesoporous structure to the best of our knowledge. The pore sizes of MSbNSs are tunable by carefully controlling the partial oxidation of Sb nuclei and the selective etching of the as-formed Sb2O3. MSbNSs showed a wide absorption from visible to second near-infrared (NIR-II) region. Moreover, PEGylated MSbNSs were degradable and the degradation mechanism was further explained. The NIR-II photothermal performance of MSbNSs was excellent with a high photothermal conversion efficiency of ~44% and intensive NIR-II photoacoustic signal. MSbNSs showed great potential as multifunctional nanomedicines for NIR-II photoacoustic imaging guided synergistic photothermal/chemo therapy in vivo. Our novel selective etching process would contribute to the development of various semimetallic mesoporous structures and efficient multimodal nanoplatforms for theranostics.
Keywords
Mesoporous Antimony, Photodegradable, Photothermal therapy, Photoacoustic imaging
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Degradable mesoporous semimetal antimony nanospheres for near-infrared II multimodal theranostics
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This preprint is under consideration at a Nature Portfolio Journal. A preprint is a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Nature journals have partnered with Research Square to offer In Review, a journal-integrated preprint deposition service.
Article
Junle Qu
Shenzhen University
Corresponding Author
ORCiD: https://orcid.org/0000-0001-7833-4711
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Under Review
Version 1
Posted 27 May, 2021
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Metallic and semimetallic mesoporous frameworks are of great importance owing to their unique properties and broad applications. However, semimetallic mesoporous structures cannot be obtained by the traditional template-mediated strategies due to the inevitable hydrolytic reaction of semimetal compounds. Therefore, it is yet challenging to fabricate mesoporous semimetal nanostructures, not even mention controlling their pore sizes. Thus, we have developed a facile and robust selective etching route to synthesize monodispersed mesoporous antimony nanospheres (MSbNSs). This is the first report of semimetallic mesoporous structure to the best of our knowledge. The pore sizes of MSbNSs are tunable by carefully controlling the partial oxidation of Sb nuclei and the selective etching of the as-formed Sb2O3. MSbNSs showed a wide absorption from visible to second near-infrared (NIR-II) region. Moreover, PEGylated MSbNSs were degradable and the degradation mechanism was further explained. The NIR-II photothermal performance of MSbNSs was excellent with a high photothermal conversion efficiency of ~44% and intensive NIR-II photoacoustic signal. MSbNSs showed great potential as multifunctional nanomedicines for NIR-II photoacoustic imaging guided synergistic photothermal/chemo therapy in vivo. Our novel selective etching process would contribute to the development of various semimetallic mesoporous structures and efficient multimodal nanoplatforms for theranostics.
Figure 1
Figure 2
Figure 3
Figure 4
Figure 5
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