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Background
Several studies have shown that normal weight with central obesity (NWCO) is associated with cardiovascular disease risk factors such as hypertension, dyslipidemia and diabetes. However, the relationship between NWCO and hyperuricemia has not been studied in detail.
Methods
We investigated the association between NWCO and hyperuricemia among Japanese adults aged 40-64 years who had undergone periodic health examinations between April 2013 and March 2014. Obesity was defined as a body mass index (BMI) ≥25 kg/m 2 and central obesity was determined as a waist-to-height ratio (WHtR) ≥0.5. We classified the participants into the following groups based according to having obesity and central obesity: normal weight (BMI 18.5-24.9 kg/m 2 ) without (NW; WHtR <0.5) and with (NWCO) central obesity, and obesity without (OB) and with (OBCO) central obesity. Hyperuricemia was defined as serum uric acid >7.0 and ≥6.0 mg/dL in men and women, respectively, or under medical treatment for hyperuricemia. Alcohol intake was classified as yes (daily and occasional consumption) and none (no alcohol consumption). Odds ratios (OR) and 95% confidence intervals (CI) for hyperuricemia were calculated using a logistic regression model.
Results
We analyzed data derived from 96,863 participants (69,241 men and 27,622 women). The prevalences of hyperuricemia in men and women were respectively, 21.4% and 11.0%, and of participants with NWCO respectively 15.6% and 30.0%. The adjusted OR for hyperuricemia was significantly increased in OBCO compared with NW, regardless of sex (men: OR, 2.12; 95%CI; 2.03-2.21; women: OR, 3.54; 95%CI, 3.21-3.90) and were statistically significant in NWCO compared with NW (men: OR, 1.44; 95%CI, 1.36-1.52; women: OR, 1.41; 95%CI, 1.27-1.57). The results were similar regardless of alcohol consumption.
Conclusions
We found that NWCO and OBCO were associated with hyperuricemia in middle-aged Japanese men and women. Middle-aged Japanese adults with normal weight but having central obesity should be screened using a combination of BMI and WHtR and educated about how to prevent hyperuricemia.
Keywords
normal weight central obesity, body mass index, waist-to-height ratio, hyperuricemia
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Peer Review Timeline
CURRENT STATUS: Published
View the published article at BMC Endocrine Disorders.
No community comments so far
Submission checks complete
On 19 Dec, 2019
Editorial decision: Accept
On 19 Dec, 2019
No comments provided
Editorial decision: Minor revision
On 17 Dec, 2019
Editor assigned
On 06 Dec, 2019
Submission checks complete
On 05 Dec, 2019
Editor invited
On 05 Dec, 2019
No comments provided
Editorial decision: Minor revision
On 22 Nov, 2019
Reviewer #9 agreed
On 21 Nov, 2019
Reviewer #8 agreed
On 21 Nov, 2019
Review #2 received
Received 20 Nov, 2019
Reviewer #7 agreed
On 20 Nov, 2019
Review #4 received
Received 20 Nov, 2019
Reviewer #6 agreed
On 19 Nov, 2019
Reviewer #5 agreed
On 18 Nov, 2019
Review #1 received
Received 16 Nov, 2019
Reviewer #4 agreed
On 15 Nov, 2019
Reviewer #3 agreed
On 12 Nov, 2019
Reviewers invited
Invitations sent on 12 Nov, 2019
Reviewer #1 agreed
On 12 Nov, 2019
Reviewer #2 agreed
On 12 Nov, 2019
Editor assigned
On 01 Nov, 2019
Submission checks complete
On 31 Oct, 2019
Editor invited
On 31 Oct, 2019
Version 1
Posted 18 Sep, 2019
No comments provided
Editorial decision: Minor revision
On 31 Oct, 2019
Review #2 received
Received 30 Oct, 2019
Review #1 received
Received 17 Oct, 2019
Reviewer #2 agreed
On 03 Oct, 2019
Reviewer #3 agreed
On 03 Oct, 2019
Reviewer #1 agreed
On 02 Oct, 2019
Reviewers invited
Invitations sent on 30 Sep, 2019
Submission checks complete
On 13 Sep, 2019
Editor assigned
On 09 Sep, 2019
Editor invited
On 08 Sep, 2019
First submitted
On 05 Sep, 2019
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Endocrinology & Metabolism
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A new preprint design is coming!
We have improved readability, clarity, accessibility, and opportunities for engagement.
See the published version of this preprint at BMC Endocrine Disorders.
This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research article
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Published
View the published article at BMC Endocrine Disorders.
No community comments so far
Submission checks complete
On 19 Dec, 2019
Editorial decision: Accept
On 19 Dec, 2019
No comments provided
Editorial decision: Minor revision
On 17 Dec, 2019
Editor assigned
On 06 Dec, 2019
Submission checks complete
On 05 Dec, 2019
Editor invited
On 05 Dec, 2019
No comments provided
Editorial decision: Minor revision
On 22 Nov, 2019
Reviewer #9 agreed
On 21 Nov, 2019
Reviewer #8 agreed
On 21 Nov, 2019
Review #2 received
Received 20 Nov, 2019
Reviewer #7 agreed
On 20 Nov, 2019
Review #4 received
Received 20 Nov, 2019
Reviewer #6 agreed
On 19 Nov, 2019
Reviewer #5 agreed
On 18 Nov, 2019
Review #1 received
Received 16 Nov, 2019
Reviewer #4 agreed
On 15 Nov, 2019
Reviewer #3 agreed
On 12 Nov, 2019
Reviewers invited
Invitations sent on 12 Nov, 2019
Reviewer #1 agreed
On 12 Nov, 2019
Reviewer #2 agreed
On 12 Nov, 2019
Editor assigned
On 01 Nov, 2019
Submission checks complete
On 31 Oct, 2019
Editor invited
On 31 Oct, 2019
Version 1
Posted 18 Sep, 2019
No comments provided
Editorial decision: Minor revision
On 31 Oct, 2019
Review #2 received
Received 30 Oct, 2019
Review #1 received
Received 17 Oct, 2019
Reviewer #2 agreed
On 03 Oct, 2019
Reviewer #3 agreed
On 03 Oct, 2019
Reviewer #1 agreed
On 02 Oct, 2019
Reviewers invited
Invitations sent on 30 Sep, 2019
Submission checks complete
On 13 Sep, 2019
Editor assigned
On 09 Sep, 2019
Editor invited
On 08 Sep, 2019
First submitted
On 05 Sep, 2019
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Endocrinology & Metabolism
License:
This work is licensed under a CC BY 4.0 License. Read Full License
View the published article at BMC Endocrine Disorders.
Background
Several studies have shown that normal weight with central obesity (NWCO) is associated with cardiovascular disease risk factors such as hypertension, dyslipidemia and diabetes. However, the relationship between NWCO and hyperuricemia has not been studied in detail.
Methods
We investigated the association between NWCO and hyperuricemia among Japanese adults aged 40-64 years who had undergone periodic health examinations between April 2013 and March 2014. Obesity was defined as a body mass index (BMI) ≥25 kg/m 2 and central obesity was determined as a waist-to-height ratio (WHtR) ≥0.5. We classified the participants into the following groups based according to having obesity and central obesity: normal weight (BMI 18.5-24.9 kg/m 2 ) without (NW; WHtR <0.5) and with (NWCO) central obesity, and obesity without (OB) and with (OBCO) central obesity. Hyperuricemia was defined as serum uric acid >7.0 and ≥6.0 mg/dL in men and women, respectively, or under medical treatment for hyperuricemia. Alcohol intake was classified as yes (daily and occasional consumption) and none (no alcohol consumption). Odds ratios (OR) and 95% confidence intervals (CI) for hyperuricemia were calculated using a logistic regression model.
Results
We analyzed data derived from 96,863 participants (69,241 men and 27,622 women). The prevalences of hyperuricemia in men and women were respectively, 21.4% and 11.0%, and of participants with NWCO respectively 15.6% and 30.0%. The adjusted OR for hyperuricemia was significantly increased in OBCO compared with NW, regardless of sex (men: OR, 2.12; 95%CI; 2.03-2.21; women: OR, 3.54; 95%CI, 3.21-3.90) and were statistically significant in NWCO compared with NW (men: OR, 1.44; 95%CI, 1.36-1.52; women: OR, 1.41; 95%CI, 1.27-1.57). The results were similar regardless of alcohol consumption.
Conclusions
We found that NWCO and OBCO were associated with hyperuricemia in middle-aged Japanese men and women. Middle-aged Japanese adults with normal weight but having central obesity should be screened using a combination of BMI and WHtR and educated about how to prevent hyperuricemia.
This is a list of supplementary files associated with this preprint. Click to download.
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