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Research article
Peter Berek
Vychodoslovensky Ustav Srdcovych a Cievnych Chorob AS
Corresponding Author
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This work is licensed under a CC BY 4.0 License. Read Full License
Background: Extracranial carotid artery disease is considered a risk factor for developing acute cerebrovascular diseases. The paper presents the “Stroke-Stop” formula proposed for the determination of the risk of developing stroke in patients with asymptomatic internal carotid artery (ICA) stenosis. The formula is based on a mathematical calculation of the major risk factors for stroke: the degree of ICA stenosis, the morphological structure of the atherosclerotic plaque and the level of lipoprotein-associated phospholipase A2 (Lp-PLA2) concentration.
Methods: The study included 70 patients with atherosclerotic ICA stenosis. Among vascular inflammatory markers, Lp-PLA2 was determined with concentration 252.7-328.6 mg/l. The obtained results were evaluated using descriptive statistics (the frequency, percentage ratio) as well as the one-way analysis of variance (ANOVA) and chi-square test.
Results: The risk of stroke development is eminently increasing with the progression of ICA stenosis and elevation of Lp-PLA2 levels. In patients with soft atherosclerotic plaque, the risk of stroke development was significantly higher in correlation with patients with hard atherosclerotic plaque. Based on calculations using “Stroke-Stop” formula, three main groups were generated: low (<70 points), medium (70 – 100 points) and high (>100 points) risk of stroke development.
Conclusions: The “Stroke-Stop” formula may serve as an additional criterion for individual selection of patients with asymptomatic ICA stenosis for carotid endarterectomy. This model could be used as a diagnostic and prognostic tool to identify patients with potentially high risk development of ischemic stroke in clinical praxis.
Keywords
atherosclerosis, carotid artery stenosis, vulnerable plaque, vascular markers, stroke, personalized medicine
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CURRENT STATUS: Published
View the published article at BMC Neurology.
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Posted 09 Dec, 2020
No community comments so far
Editorial decision: Major revision
On 07 Feb, 2021
Review #2 received
Received 31 Jan, 2021
Reviewer #3 agreed
On 02 Jan, 2021
Review #1 received
Received 31 Dec, 2020
Reviewer #2 agreed
On 19 Dec, 2020
Reviewers invited
Invitations sent on 15 Dec, 2020
Reviewer #1 agreed
On 15 Dec, 2020
Editor assigned
On 23 Aug, 2020
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On 23 Aug, 2020
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On 23 Aug, 2020
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A new preprint design is coming!
We have improved readability, clarity, accessibility, and opportunities for engagement.
See the published version of this preprint at BMC Neurology.
This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research article
Peter Berek
Vychodoslovensky Ustav Srdcovych a Cievnych Chorob AS
Corresponding Author
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Published
View the published article at BMC Neurology.
Version 1
Posted 09 Dec, 2020
No community comments so far
Editorial decision: Major revision
On 07 Feb, 2021
Review #2 received
Received 31 Jan, 2021
Reviewer #3 agreed
On 02 Jan, 2021
Review #1 received
Received 31 Dec, 2020
Reviewer #2 agreed
On 19 Dec, 2020
Reviewers invited
Invitations sent on 15 Dec, 2020
Reviewer #1 agreed
On 15 Dec, 2020
Editor assigned
On 23 Aug, 2020
Submission checks complete
On 23 Aug, 2020
Editor invited
On 23 Aug, 2020
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
License:
This work is licensed under a CC BY 4.0 License. Read Full License
View the published article at BMC Neurology.
Background: Extracranial carotid artery disease is considered a risk factor for developing acute cerebrovascular diseases. The paper presents the “Stroke-Stop” formula proposed for the determination of the risk of developing stroke in patients with asymptomatic internal carotid artery (ICA) stenosis. The formula is based on a mathematical calculation of the major risk factors for stroke: the degree of ICA stenosis, the morphological structure of the atherosclerotic plaque and the level of lipoprotein-associated phospholipase A2 (Lp-PLA2) concentration.
Methods: The study included 70 patients with atherosclerotic ICA stenosis. Among vascular inflammatory markers, Lp-PLA2 was determined with concentration 252.7-328.6 mg/l. The obtained results were evaluated using descriptive statistics (the frequency, percentage ratio) as well as the one-way analysis of variance (ANOVA) and chi-square test.
Results: The risk of stroke development is eminently increasing with the progression of ICA stenosis and elevation of Lp-PLA2 levels. In patients with soft atherosclerotic plaque, the risk of stroke development was significantly higher in correlation with patients with hard atherosclerotic plaque. Based on calculations using “Stroke-Stop” formula, three main groups were generated: low (<70 points), medium (70 – 100 points) and high (>100 points) risk of stroke development.
Conclusions: The “Stroke-Stop” formula may serve as an additional criterion for individual selection of patients with asymptomatic ICA stenosis for carotid endarterectomy. This model could be used as a diagnostic and prognostic tool to identify patients with potentially high risk development of ischemic stroke in clinical praxis.
Figure 1
Figure 2
Figure 3
Figure 4
Figure 5
Figure 6
Figure 7
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