The measurements of one of the major greenhouse gases, carbon dioxide (CO 2 ), are being made using dedicated satellite remote sensing since the launch of the greenhouse gases observing satellite (GOSAT) by JAXA in 2009 and NASA’s Orbiting Carbon Observatory-2 (OCO-2). In the past 10 years, estimation of CO 2 fluxes from land and ocean using the earth system models (ESMs) and inverse modelling of in situ atmospheric CO 2 data have also made significant progress. In this article, we attempt, for the first time, to evaluate the CO 2 fluxes simulated by an earth system model (MIROC-ES2L) using GOSAT observations and the fluxes estimated by an inverse model (MIROC4-Inv) for the period 2009-2014. Further, we use the OCO-2 measurements for testing the consistency of inversion results for the period 2014-2018, along with the GOSAT data. Both MIROC-ES2L and MIROC4-Inv fluxes are used in the MIROC4-atmospheric chemistry transport model (referred to as ACTM_ES2LF and ACTM_InvF, respectively) for calculating CO 2 concentrations that are sampled at the time and location of the satellite measurements. Our results suggest the inverse model using in situ data are more consistent with the OCO-2 retrievals, compared to those of the GOSAT XCO 2 data, suggesting possible improvements in the present GOSAT retrieval system by better accounting for the degradation correction of the TANSO-FTS. The ACTM_ES2LF simulation shows a slightly weaker seasonal cycle for the meridional profiles of CO 2 fluxes, compared to that from the ACTM_InvF. This difference is revealed by greater ACTM_ES2LF vs GOSAT differences, compared to those of ACTM_InvF vs GOSAT. We also find that the simulated seasonal cycle amplitude of XCO 2 by ACTM_ES2LF are slightly weaker compared to those observed by GOSAT or ACTM_InvF. Using remote sensing based global products of leaf area index (LAI) and gross primary productivity (GPP) over land, we show a weaker sensitivity of MIROC-ES2L biospheric activities to the weather and climate in the tropical regions. Our results clearly suggest the usefulness of XCO 2 measurements by satellite remote sensing for evaluation of large-scale ESMs, which so far remained untested by the sparse in situ data.