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Research Article
Xiangyan Liu
Shandong Provincial Hospital
Corresponding Author
ORCiD: https://orcid.org/0000-0002-6998-1543
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This work is licensed under a CC BY 4.0 License. Read Full License
Esophageal squamous cell carcinoma (ESCC) is one of the most common devasting tumor around the world, characterized by persistent hypoxia. Hypoxia-inducible factor-2α (hif-2α) has been regarded as an oncogene in many kinds of cancers, exerting its function to promote tumor growth and metastasis. But the role of hif-2α in ESCC remains largely unknown. In this study, we discovered hif-2α was overexpressed in ESCC and could promote proliferation and metastasis in ESCC cells. Functionally, hif-2α facilitated EMT through Notch pathway in ESCC. Moreover, we identified hif-2α as an independent factor that predict poor prognosis in ESCC patients. These findings suggested that hif-2α is a key regulator of EMT and played a critical role in promoting ESCC progression.
Keywords
hif-2α, Notch, EMT, ESCC
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A new preprint design is coming!
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This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Research Article
Xiangyan Liu
Shandong Provincial Hospital
Corresponding Author
ORCiD: https://orcid.org/0000-0002-6998-1543
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
History
CURRENT STATUS: Posted
Version 1
Posted 03 Jun, 2021
No community comments so far
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Esophageal squamous cell carcinoma (ESCC) is one of the most common devasting tumor around the world, characterized by persistent hypoxia. Hypoxia-inducible factor-2α (hif-2α) has been regarded as an oncogene in many kinds of cancers, exerting its function to promote tumor growth and metastasis. But the role of hif-2α in ESCC remains largely unknown. In this study, we discovered hif-2α was overexpressed in ESCC and could promote proliferation and metastasis in ESCC cells. Functionally, hif-2α facilitated EMT through Notch pathway in ESCC. Moreover, we identified hif-2α as an independent factor that predict poor prognosis in ESCC patients. These findings suggested that hif-2α is a key regulator of EMT and played a critical role in promoting ESCC progression.
Figure 1
Figure 2
Figure 3
Figure 4
Figure 5
Figure 6
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