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Research Article
Eun hee Chung
Chungnam National University Hospital
Corresponding Author
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This work is licensed under a CC BY 4.0 License. Read Full License
Background: Respiratory infection in particular community acquired pneumonia (CAP) in children is a major disease that ranks high in outpatient and inpatient cases. The causes of CAP vary depending on the individual susceptibility, epidemiological characteristics of the community, and season. We performed this study to establish nationwide surveillance network system and identify the causative agents for CAP and antibiotics resistance in Korean children with CAP..
Methods: The monitoring network was composed of the 28 secondary and tertiary medical institutions. Upper and lower respiratory samples were assayed using culture or Polymerase chaini reaction (PCR) from Aug 2018 to May 2020.
Results: A total of 1023 cases were registered in patients with CAP, and 264 cases (25.8%) were isolated by culture, S. aureus 131 cases (12.8%), S. pneumoniae 92 cases (9%), H. influenzae 20 cases (2%). PCR of atypical pneumonia pathogen revealed 422 cases of M. pneumoniae (41.3%). Respiratory virus showed positive rates in 65.7% by multiplex PCR test and of them, human rhinovirus was most highest with 312 cases (30.5%). The proportion of mixed infection was 49.2%. The rate of antibiotics resistance showed similar results as previous reports.
Conclusions: It will identify the pathogens that cause respiratory infections, and analyze the current status of antibiotic resistance to provide scientific evidence for management policies of domestic respiratory infection. Also, in preparation for the new epidemic, including COVID19, monitoring of respiratory infections in children and adolescents, has become more important, and research should be continuously conducted in the future.
Keywords
pneumonia, child, surveillance, epidemiology
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No competing interests reported.
This is a list of supplementary files associated with this preprint. Click to download.
- additionalfile1.pdf
Additional file 1. The Korean Childhood Community Acquired Pneumonia Study Group; KoC-CAPS
- additionalfile2.pdf
Additional file 2. Community acquired pneumonia -Clinical information records
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CURRENT STATUS: Under Review
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Posted 08 Jun, 2021
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Editorial decision: Major revision
On 24 Sep, 2021
Reviews received
Received 20 Sep, 2021
Reviews received
Received 22 Aug, 2021
Reviewers agreed
On 06 Aug, 2021
Reviewers agreed
On 10 Jun, 2021
Reviewers invited
Invitations sent on 10 Jun, 2021
Editor assigned
On 10 Jun, 2021
Editor invited
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On 04 Jun, 2021
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Subject Areas
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A new preprint design is coming!
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This preprint is under consideration at BMC Infectious Diseases. A preprint is a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research Article
Eun hee Chung
Chungnam National University Hospital
Corresponding Author
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Under Review
Version 1
Posted 08 Jun, 2021
No community comments so far
Editorial decision: Major revision
On 24 Sep, 2021
Reviews received
Received 20 Sep, 2021
Reviews received
Received 22 Aug, 2021
Reviewers agreed
On 06 Aug, 2021
Reviewers agreed
On 10 Jun, 2021
Reviewers invited
Invitations sent on 10 Jun, 2021
Editor assigned
On 10 Jun, 2021
Editor invited
On 04 Jun, 2021
Submission checks complete
On 04 Jun, 2021
First submitted
On 19 May, 2021
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Infectious Diseases
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background: Respiratory infection in particular community acquired pneumonia (CAP) in children is a major disease that ranks high in outpatient and inpatient cases. The causes of CAP vary depending on the individual susceptibility, epidemiological characteristics of the community, and season. We performed this study to establish nationwide surveillance network system and identify the causative agents for CAP and antibiotics resistance in Korean children with CAP..
Methods: The monitoring network was composed of the 28 secondary and tertiary medical institutions. Upper and lower respiratory samples were assayed using culture or Polymerase chaini reaction (PCR) from Aug 2018 to May 2020.
Results: A total of 1023 cases were registered in patients with CAP, and 264 cases (25.8%) were isolated by culture, S. aureus 131 cases (12.8%), S. pneumoniae 92 cases (9%), H. influenzae 20 cases (2%). PCR of atypical pneumonia pathogen revealed 422 cases of M. pneumoniae (41.3%). Respiratory virus showed positive rates in 65.7% by multiplex PCR test and of them, human rhinovirus was most highest with 312 cases (30.5%). The proportion of mixed infection was 49.2%. The rate of antibiotics resistance showed similar results as previous reports.
Conclusions: It will identify the pathogens that cause respiratory infections, and analyze the current status of antibiotic resistance to provide scientific evidence for management policies of domestic respiratory infection. Also, in preparation for the new epidemic, including COVID19, monitoring of respiratory infections in children and adolescents, has become more important, and research should be continuously conducted in the future.
Figure 1
Figure 2
Figure 3
Figure 4
No competing interests reported.
This is a list of supplementary files associated with this preprint. Click to download.
- additionalfile1.pdf
Additional file 1. The Korean Childhood Community Acquired Pneumonia Study Group; KoC-CAPS
- additionalfile2.pdf
Additional file 2. Community acquired pneumonia -Clinical information records
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