Data were analyzed for 457,479 hospitalizations recorded in the DATASUS public system, in the period from 2008 to 2018, in all age groups (from under 1 year to over 80 years). Of these, 51.47% were in people identified with males (235,483 hospitalizations, with minimum of 134, maximum of 145.346, average of 21.407,54, median of 2,515, standard deviation - SD - of +/-43,438.13, 95% confidence interval - 95% CI - of +/-175.44) and 48.53% with females (221,996 hospitalizations, with a minimum of 141, maximum of 146,863, average of 20,181.45, median of 1,582, SD of +/-43,953.26, 95% CI of +/-182.83) (p-value 0.088), according to table 1. Among the immunopreventable diseases evaluated, 55.69% of hospitalizations were associated with influenza disease, being the main cause observed, with 145,346 hospitalizations associated with males and 146,863 with females. The disease with fewer hospitalizations observed in this analysis was rubella, with 275 hospitalizations in the analyzed period (134 hospitalizations reported to males and 141 to females).
These 457,479 hospitalizations recorded in the system, in the period from 2008 to 2018, totalled a direct cost of R$389,243,264.85. Of these, 53.17% were in people identified as males (R$206,943,642.06 direct costs with hospitalizations, with a minimum of R$35,156.59, a maximum of R$108,903,219.60, average of R$18,813,058.37, median of R$8,596,673.05, SD of +/-R$32,021,390.25, 95% CI of +/-R$4,362.76) and 46.83% for females (R$182,299,622.79 direct costs from hospitalizations, with a minimum of R$109,836.23, maximum of R$107,882,552.40, an average of R$16,572,692.98, median of R$1,921,686.50, SD of +/-R$31,942,325.80, 95% CI of +/-R$4,636.83) (p-value 0.036), according to table 2. Among the hospitalizations evaluated, 55.69% of hospitalizations were associated with influenza disease, with the main hospitalization in direct costs observed, with R$108,903,219.58 in costs associated with males and R$107,882,552.40 to females. The lower direct cost problem associated with hospitalizations observed in this analysis was rubella, with a value of R$144,992.82 (R$35,156.59 associated with males and R$109,836.23 for females).
Regarding the distribution of hospitalizations related to immunopreventable diseases studied in Brazil, the time series analyses were presented in Table 3, demonstrating, mostly, a stationary or decreasing trend in relation to the total number of hospitalizations, for both sexes, without differences in trends between the male and female groups. Some particularities were observed, as in the case of mumps disease that presented an increasing trend in the country, with statistical significance (p-value 0.005 in the male group and 0.000 in the female group).
Regarding the distribution of total direct costs related to hospitalizations related to immunopreventable diseases researched in Brazil, the time series analyses were presented in table 4, demonstrating, for the most part, a stationary or decreasing trend for both sexes, without differences in trends between the groups. Some particularities were observed, as in the case of mumps disease that presented an increasing trend in the country, with statistical significance (p-value of 0.000 for both sexes). And the case of rubella disease, which showed a decreasing trend in the male group (p-value of 0.008) and stationary in the female group (p-value of 0.480).