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Research article
Miso Kim
Seoul National University Hospital
Corresponding Author
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Systemic inflammatory response index such as neutrophil-to-lymphocyte ratio (NLR) or platelet-to-lymphocyte ratio (PLR) has been investigated as prognostic indicators in various tumors including diffuse large B-cell and peripheral T-cell lymphomas. The aim of this study is to evaluate the prognostic values of the pretreatment NLR and PLR in patients with advanced, extranodal NK/T-cell lymphoma, nasal type (NTCL). Sixty patients with newly diagnosed, stage III/IV NTCL between January 2000 and August 2015 were evaluated retrospectively. Correlations of pre-NLR and –PLR with other clinical factors were investigated. Kaplan-Meier plot was used to analyze survivals according to pre-NLR and -PLR levels. The prognostic effects of variables were investigated using a Cox proportional regression model. Based on the optimized cut-off levels, patients were classified into two different groups. After a median follow up of 15 months, the median overall survival (OS) in the low and high pre-NLR groups was 33.4 and 6.6 months, respectively. In multivariate analysis, high pre-NLR was significantly associated with reduced OS (hazard ratio HR 3.59, 95% CI 1.77-7.26; p < .001). On the contrary, the median OS in the low and high pre-PLR was 6.2 and 22.3 months, respectively. Multivariate analysis revealed that low pre-PLR was in a significant correlation with the worse OS (HR 3.78, 95% CI 1.79-7.95; p < .001). The high pre-NLR and low pre-PLR are independent poor prognostic factors for reduced survivals of patients with advanced NTCL, and might provide additional prognostic powers to identify high-risk, advanced NTCL patients.
Keywords
Extranodal NK/T-cell lymphoma, nasal type; neutrophil-to-lymphocyte ratio; platelet-to-lymphocyte ratio; and prognosis
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A new preprint design is coming!
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This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Research article
Miso Kim
Seoul National University Hospital
Corresponding Author
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
History
CURRENT STATUS: Posted
Version 1
Posted 23 Sep, 2019
No community comments so far
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Systemic inflammatory response index such as neutrophil-to-lymphocyte ratio (NLR) or platelet-to-lymphocyte ratio (PLR) has been investigated as prognostic indicators in various tumors including diffuse large B-cell and peripheral T-cell lymphomas. The aim of this study is to evaluate the prognostic values of the pretreatment NLR and PLR in patients with advanced, extranodal NK/T-cell lymphoma, nasal type (NTCL). Sixty patients with newly diagnosed, stage III/IV NTCL between January 2000 and August 2015 were evaluated retrospectively. Correlations of pre-NLR and –PLR with other clinical factors were investigated. Kaplan-Meier plot was used to analyze survivals according to pre-NLR and -PLR levels. The prognostic effects of variables were investigated using a Cox proportional regression model. Based on the optimized cut-off levels, patients were classified into two different groups. After a median follow up of 15 months, the median overall survival (OS) in the low and high pre-NLR groups was 33.4 and 6.6 months, respectively. In multivariate analysis, high pre-NLR was significantly associated with reduced OS (hazard ratio HR 3.59, 95% CI 1.77-7.26; p < .001). On the contrary, the median OS in the low and high pre-PLR was 6.2 and 22.3 months, respectively. Multivariate analysis revealed that low pre-PLR was in a significant correlation with the worse OS (HR 3.78, 95% CI 1.79-7.95; p < .001). The high pre-NLR and low pre-PLR are independent poor prognostic factors for reduced survivals of patients with advanced NTCL, and might provide additional prognostic powers to identify high-risk, advanced NTCL patients.
Figure 1
Figure 2
Figure 3
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