Geological Environmental and Socioeconomic Factors of Disease Spectrum in Chinese Population

Through the correlation analysis of statistical data of provinces and autonomous regions, this paper has comprehensively, systematically and quantitativelystudied the natural geography, geological environment, socioeconomic, geochemical and hydrogeological constraints of endemic diseases, cancer and common diseases in mainland China. In order to prevent the rational design of medical experimental plan, provide a scientific basis. The results show that, the occurrence of different human diseases is subject to different environmental conditions. Keshan disease, Kashin-Beck disease, endemic goiter and fluorosis, in addition to soil selenium, groundwater iodine and fluoride, but also by a variety of environmental factors; Total nitrogen in soil has an promote effect to gastric cancer and liver cancer. The amount of nitrogen fertilizer has an effect to rectal cancer, pancreatic cancer and lymphatic cancer, and soil arsenic has significant inhibitory effect to lung cancer, pancreatic cancer and lymphatic cancer. River water hardness, salinity and soil calcium, magnesium and other elements for a variety of cancers may also have inhibitory effect. Cerebrovascular disease and myocardial infarction have shown the features of urban population in cold and droughts in the north; Chronic obstructive pulmonary disease and respiratory tract infections show the features of the population in the mountain mining and smelting industries; Chronic nephropathy reflects the characteristics of arsenic and sulfur poisoning in plateau areas; Alzheimer disease shows the characteristics of people in farming areas. The average content of elements in sediments of water system, the county territory of 26 longevity counties in China are relatively high compared with the national average, and the human beneficial elements are relatively high; while the harmful elements in human bodies are relatively low. If we make full use of soil (stream sediment) geochemical measurement data, combined with the results of this study, it is possible to greatly refine the spatial distribution prediction maps of population diseases in mainland China. The author believes that by improving the climatic and geographical conditions of residence and increasing the intake of certain chemical elements in an appropriate form(Especially the food chain diet structure), it will certainly play an important role in reducing the occurrence and development of diseases and improving human health. S-0.3469 expectancy Ale-0.3797, potassium K-0.3409 in sediments, nitrogen fertilization Nf-0.3076, groundwater fluorine RwF-0.2754, drinking water iodine DwI-0.2648. clinical manifestations of endemic fluorosis are dental fluorosis and skeletal fluorosis. lineage is counted. The results show that the anatomically similar organs and visceras, its incidence rate has geographical spatial aggregation. considered various physical geography and socio-economic factors, but failed to involve elemental data in human tissues; The previous conclusions about the effects of selenium on human health are reproducible here. It may be that the two are not a simple linear dose-response relationship, but a threshold-effect relationship. If we make full use of soil (stream sediment) geochemical measurement data (1 point / km2), combined with the results of this study, it is possible to greatly refine the spatial distribution prediction maps of population diseases in mainland China.

In 1960, Legon, Stocks, and David noticed that residents of North Wales and Cheshire, living in areas with high organic matter content, had a higher incidence of gastric cancer. Stocks and David believe there is a positive correlation between gastric cancer incidence and zinc, chromium, and cobalt in soil [4] (Stocks,1964).
In 1980, Marjanen discussed that soil manganese concentrations in Finland seemed to have a strong anticancer effect, and high concentrations of zinc and copper also seemed to be associated with higher cancer mortality. Norie and Foster study finds that digestive system cancers occur less frequently in hard water areas in Canada.
From the 1970s to the 1980s, many studies in China suggested that the high incidence of nasopharyngeal cancer in Sihui County, Guangdong was related to higher nickel content and lower selenium content in the local area. In Shunde, the content of copper, molybdenum and zinc in soil and water is higher in the severely ill area than in the mildly ill area, while the content of manganese, barium and strontium is lower in the severely ill area than in the mildly ill area. 30 counties in Jiangxi, analysis of the relationship between lung cancer, colon cancer, rectal cancer and soil dose-response, negative correlation between selenium and malignant tumors; Co / Se, Mn / Se values are positively correlated with rectal cancer; Bi / Se positively correlated with colon cancer; When selenium and molybdenum are both low, malignant tumor mortality is high [5] (Liu Yanfang, et al.1987).
From the late 1990s to the present, people have paid more attention to the relationship between soil and human cancer, and pollutants with clear cancer risk.
Based on relative risk, dose-effect, and multivariate analysis results, negative correlation between soil selenium content and digestive system cancer in Jiangxi Province [6] (Liu Yanfang, et al.1994). Correlation and comparative analysis show that, negative correlation between zinc content in soil and rice and digestive system cancer in Jiangxi Province [7] (Fan Guangqin.1997).
The high-low incidence areas of gastric, esophageal and liver cancer in China have regional distribution characteristics and unique geological environments, Some elements in soil, drinking water, food and human body are significantly positively or negatively correlated with incidence [8] [9] (Wang Xiaomei.1999;ZENG Zhao-hua, et al.2000).
Grade correlation coefficient between cancer mortality and vanadium in soil, respectively, gastric cancer -0.4769,colorectal cancer -0.3179 [13] (Zeng Zhaohua,et al.2002).Comprehensive analysis shows that the death rate of various cancers is related to the abundance and deficiency of many trace elements in the soil [14] (Qin Junfa,et al.2004).
High incidence of gastric cancer in Zanhuang County, Hebei Province, contamination of benzopyrene, nitrosamines, aflatoxins B1, and G1 in residents' drinking water can be detected, nitrate and nitrite content are significantly higher than in low-incidence areas [15] (Zhang Xiulan, et al.2002). The contents of nitrate nitrogen and nitrite nitrogen in drinking water, serum and saliva of residents with high incidence of gastric cancer were significantly higher than those in low incidence areas [16] (Zhao Shuqing.2005). Arsenic content in soil, drinking water, and human hair in low-incidence areas of gastric cancer in Fujian is higher than in high-incidence areas, indicating that moderate arsenic can inhibit cancer [17] (Chen Boyang.2008). Gastric cancer was positively correlated with soil Pb and negatively correlated with Mo and Se. The circulation of chemical elements in the environment through the ecosystem leads to a lack of Mo and Se and an increase in the Cu / Zn ratio, may be an important risk factor for gastric cancer in Xianyou County, Fujian [18] (Li Hongtu.2008).
Numerous studies have proven that compound contamination and viral infection are two important causes of cancer. Compound-compound,compound-viral combination increase the risk of cancer. Mutation test results become positive when the two are combined [19] (Wang Xiaomeng.2013).
Nitrosamines,molds,aflatoxins, human papillomavirus infection, occupational environment, air radon pollution, indoor coal-fired air pollution are the causes of the high incidence of cancer in parts of China [20] (Zou Xiaonong. 2014).Lung cancer in eastern Yunnan is related to its special geographical environment and coal resources, indoor combustion of coal,pollution exposure, family aggregation and genetic susceptibility are the main factors for the higher incidence of lung cancer [21] (Li Jihua.2014).
The geographical distribution of cancer villages in China is consistent with the distribution of water pollution and air pollution, there is a positive correlation between the number of cancer villages in each province and the total GDP of each province [22] (Liu Tongshan. 2016).
Based on the data of China's tumor registration area from 2005 to 2012, Zhang Calculated the comprehensive correlation degree, The death latency of gastric nitrogen, liver cancer, and esophageal cancer caused by ammonia nitrogen emissions is 1 year, the incubation period for colorectal cancer deaths is 1 year in men and 0 years in women [23] (Zhang Rongyan, et al.2016).
The incubation periods of male lung cancer caused by atmospheric pollutants sulfur dioxide, nitrogen oxides and smoke and dust are 5 years, 3 years, and 5 years, respectively;the incubation period that causes female lung cancer is 5 years, 4 years, and 5 years, respectively [24] (Zhang Rongyan, et al.2016).
Big data clearly states again that the main causes of human cancer are acquired environment and lifestyle.
Pollution of air, soil and drinking water means that China's population is still exposed to many environmental carcinogens [25] [26] (American Cancer Society.2015; Chen W, et al.2016).
Diabetes is related to geographic climate, lifestyle, diet structure, race and virus, and aging population.
Minerals, vitamins and trace element preparations can be used as diagnostic markers for diabetes. The content of various elements in the body has significant differences in comparative studies [85]  The prevalence rate for males is highest in Hunan, followed by Tibet, Guizhou, Qinghai, and Yunnan, w h i l e l o w e s t i n Beijing, Shanghai, a n d T i a n j i n . Human tissue Se, Zn; Serum and hair F e , Z n , C a

Alzheim er's disease
The male incidence rate is highest in Shandong, followed by Zhejiang, Hebei, G u a n g d o n g , a n d Since the 1990s, people began to use geochemical methods to study the relationship between longevity and the environment, believing that the content of life elements in the longevity area is different. The one of the environmental elements, soil is at the center position. It directly affects the water nature and crops quality, through physiological and biochemical functions of life elements, Affect human health. The combined effect of excellent water and soil ecology and environment and the good eating habits make the inhabitants' physical fitness gradually increase in some areas and form a world famous longevity area. If some trace elements in the soil are high or low, local people may get endemic through the food chain.

2.Methods and techniques
Restrictions on human health and longevity factors include social, environmental and personal three aspects. Human life in a certain natural environment, its health status, longevity level will inevitably be a variety of natural factors. How the geographical environment affects human life and mental condition is still a weak link [95] .
The author has collected a large number of Chinese provinces and municipalities disease statistics, including 1959-1982 incidence of Keshan disease, Kashin-Beck disease, endemic goiter, dental fluorosis, fluorosis, 2015 incidence of diabetes, incidence in 2008 of nasopharyngeal cancer, esophageal cancer, stomach cancer, liver cancer, lung cancer, bladder cancer, leukemia, Lymphoma, colorectal cancer, data on causes of death from 1990 to 2013, the proportion of centenarians in longevity township, corresponding altitude Alt / m, annual average temperature Tat / ℃, precipitation Pre / mm, per capita income Pci, soil pH, organic carbon OrC, Total nitrogen TN, total S and Se, effective sulfur efS, effective manganese efMn, effective molybdenum efMo [96] [97] , elemental concentrations of water system sediments [98] , river water hardness Rwh, river water salinity Rws, groundwater fluorine content GwF, drinking water iodine content DwI [99] . Through the correlation analysis, studied the natural geography, geological environment, socioeconomic, geochemical and hydrogeological factors of the disease lineage, and provide a scientific basis for the rational design of preventive medical experimental plan.
A statement All materials used in this article have been published publicly and are listed as references. That all experiments on humans were approved by the corresponding agencies.
All experiments and methods in this article were carried out in accordance with relevant guidelines and regulations.
This article belong personal amateur research. All experimental schemes do not require the approval of a designated institution.
This study is public and transparent in nature and has obtained sufficient informed consent from all participants.
Data Availability The datasets generated during and/or analysed during the current study are available from the corresponding author on reasonable request.

3.Endemic disease's geological environment factors
China's diverse terrain, climate, soil and biome organic combination become different nature character ecological landscape. Due to the abnormal ecological environment or people's own special living habits, the balance between the human body and the ecological environment is destroyed, which affects health and causes endemic diseases.
Keshan disease and Kashin-Beck disease in China are mainly distributed in the area of northeast Sanjiang to the southwestern Sanjiang area, mainly in the area of brown-colored soil series. This is a form of endemic cardiomyopathy, predominantly for children under 10 and women of childbearing age. The study found that a variety of environmental factors and the occurrence of Keshan disease have different degrees of correlation [100] .
This study shows that the incidence of Keshan disease is positively correlated with soil organic Kashin-Beck disease ecological environment survey showed that ward soil, food and dietary selenium levels were significantly lower, in addition there are other environmental factors and selenium deficiency compound cause disease [100] .
This study showed that the incidence of Kashin-Beck disease was significantly positively Iodine deficiency disease in almost all parts of China have varying degrees distribution of the disease, in the mountains more than plains, inland more than the coast, especially in the grasslands and plateau areas more serious [100] .
This study showed that the incidence of endomic goiter was significantly positively correlated and hardness in drinking water [100] .
This research shows that, there was a significant positive correlation between dental fluorosis and groundwater fluorine content GwF0. 6264 The background values of fluorine in soil and sediments in northern China were lower than those in the south, but the mineralization of groundwater increased due to the transpiration enrichment. The F, Ca, Mg concentrations are relatively high, Fe and Al ion concentrations are relatively reduced, the antagonism of various elements together determine the body's ability to absorb fluorine, exacerbated the degree of harm to human body fluoride [101] .
In recent years, the incidence of diabetes showed a significant trend of increasing with time, at the same time there are obvious differences in spatial distribution [102] [103] . Correlation analysis showed that there was a significant positive correlation between the disease and per capita income    [104] . The distribution of cancer villages in China is closely related to rivers. Environmental pollution, especially water pollution, is the chief culprit in the cancer village [105] . J.Z.Gong(2019) established a map of the relationship between water soil geochemical anomalies (contamination sources) and geotechnical hydrological conditions (migration pathways) and resident cancer distribution (sensitive receptors) [106] .

4.The geological environment factors of cancer incidences
According to the incidence rate data of each province and city, the disease related lineage is counted. The results show that the anatomically similar organs and visceras, its incidence rate has geographical spatial aggregation. Uses the data on various cancer rates in mainland China in 2008 [10] , the author carried out the relevant analysis, come to different human diseases environmental constraints pedigree. All kinds of cancer male and female with environmental factors are generally the same, but there are also some differences. For different diseases, the same indicator may be the opposite effect. In many disease factors, we can find the shadows of the altitude elevation.
According the field survey data, J.Z. Gong has established a dose -response function between groundwater NO3content and the incidence of cancer [107] .
The above shows that soil total nitrogen on gastric cancer, liver cancer has a promoting effect, the amount of nitrogen fertilizer on pancreatic cancer, lymphoma has a promoting effect, soil As has obvious inhibitory effect on lung cancer, pancreatic cancer and lymphoma. River water hardness, degree of mineralization and soil Ca, Mg, for many cancers also have inhibitory effect.

The lineages of geological environmental factors of the death cause
As a result of the Global Burden of Disease Project jointly funded by scholars from China and the United States, in a sense, the rapid development of China is also reflected in the changes in the disease spectrum in all provinces. The gulf between China's health-care regions still exists, and the huge heterogeneity of mortality rates in various regions is a concentrated manifestation of this. The differences in regional development and the imbalance in the supply of health resources are the great challenges facing China's health system [108] .
We can also find some common trends in the relevant factors from the correlation analysis of

The geological environmental factors of the longevity townships
Researchers through Rugao and Ningling County, the geological background and soil, water, atmospheric environmental quality survey shows that, one of the secrets of these longevity towns lies in the good environment. The experts conducted a test and analysis of soil in four townships, namely Zhongxiang City in Hubei province, Baipu Town in Rugao City in Jiangsu province and Ningling County in Henan province. The results showed that, the average content of iodine, zinc and selenium in soils in these areas is obviously higher than other areas. More importantly, the elements content in these area is relatively high, but not too high, just to fit the needs of the body.
The survey also showed that arsenic, mercury, cadmium, lead and other toxic heavy metals in Rugao stream sediments were significantly lower. Longevity elderly hair and soil elements have similar characteristics. Guangxi Bama longevity hair has high manganese low copper characteristics.
The soil in longevity area of Hubei province is characterized by rich calcium, magnesium, strontium and fluorine, and the selenium content is 2-3 times higher than that of the general area. Centenarian hair with relatively rich in manganese , selenium and low cadmium characteristics. Grain is characterized by rich selenium iron and low cadmium [95] .
The spatial distribution of longevity population over the age of 90 in Rugao, Jiangsu province, is characterized by geographical agglomeration, with soil effective state B, F, Se, Zn and Ni to achieve a significant positive correlation [109] .
The author has counted the arithmetic average of the elemental contents in sediments of 26

7.Conclusion and discussion
The results of this study are basically consistent with previous results. There are also some differences due to different data ages, regional scopes, and indicator systems. The author comprehensively, systematically and quantitatively considered various physical geography and socio-economic factors, but failed to involve elemental data in human tissues; The previous conclusions about the effects of selenium on human health are less reproducible here. It may be that the two are not a simple linear dose-response relationship, but a threshold-effect relationship. If we make full use of soil (stream sediment) geochemical measurement data (1 point / km2), combined with the results of this study, it is possible to greatly refine the spatial distribution prediction maps of population diseases in mainland China.
In short, the statistical relationship between human disease lineages and natural geography and hydro-soil geochemistry revealed in this paper, it is worthy of further study its experimental mechanism of medical physiology. The author believes that by improving the climatic conditions of living places and increasing the intake of certain chemical elements in appropriate forms(Especially the food chain diet structure), it will certainly play an important role in reducing the occurrence and development of diseases and improving human health.  Male Cerebrovascular disease

Figure1
Correlation analysis scatter plots of Chinese population disease lineage and geological eco-environment