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Research article
Vimalanand Shrikant Prabhu
Merck & Co., Inc.
Corresponding Author
ORCiD: https://orcid.org/0000-0003-1358-8846
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background
Human papillomavirus (HPV) infection can cause various HPV-related cancers and can be prevented through HPV vaccination. While vaccination coverage (proportion ever vaccinated) estimates are available, vaccination uptake (proportion getting their first vaccine dose in a specific year) in the United States (US) is not well-known.
Methods
We conducted a retrospective analysis of MarketScan® claims database to assess the HPV vaccination uptake in the US among the 9- to 26-years-olds from 2006 to 2016. The annual uptake was the ratio between the number of enrollees for whom a first record of an HPV vaccine was found during the year and the total number of unique enrollees of similar age and gender identified that year.
Results
Uptake was below 1% among children turning 9 and 10 years old during the year. Since 2009 among female and since 2013 among males, annual uptake has been the highest in those turning 13 years old (19.7% among females and 17.6% among males in 2016). Catch-up vaccination among older adolescents and young adults increased after Advisory Committee for Immunization Practices (ACIP) recommendations, but eventually slowed down as more younger persons were vaccinated. Most young adolescents were vaccinated by pediatricians, whereas young adult women were predominantly vaccinated by obstetricians/gynecologists and young adult males by family physicians. While only about half of the adolescents had well-check visits, majority of those who initiated HPV vaccination had at least one well-check visit the same year.
Conclusion
Understanding HPV vaccination uptake can guide the development of appropriate interventions to help improve public health.
Keywords
Human papillomavirus, HPV vaccine, Vaccination uptake, Temporal trends, Sex differences, Insurance claims data
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CURRENT STATUS: Under Review
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Posted 07 Dec, 2020
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Reviewer #5 agreed
On 22 Feb, 2021
Reviewer #4 agreed
On 21 Feb, 2021
Reviewer #3 agreed
On 20 Feb, 2021
Review #1 received
Received 02 Feb, 2021
Reviewer #2 agreed
On 13 Jan, 2021
Reviewer #1 agreed
On 26 Dec, 2020
Reviewers invited
Invitations sent on 22 Dec, 2020
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This preprint is under consideration at BMC Public Health. A preprint is a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research article
Vimalanand Shrikant Prabhu
Merck & Co., Inc.
Corresponding Author
ORCiD: https://orcid.org/0000-0003-1358-8846
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Under Review
Version 1
Posted 07 Dec, 2020
No community comments so far
Reviewer #5 agreed
On 22 Feb, 2021
Reviewer #4 agreed
On 21 Feb, 2021
Reviewer #3 agreed
On 20 Feb, 2021
Review #1 received
Received 02 Feb, 2021
Reviewer #2 agreed
On 13 Jan, 2021
Reviewer #1 agreed
On 26 Dec, 2020
Reviewers invited
Invitations sent on 22 Dec, 2020
Editor assigned
On 12 Dec, 2020
Submission checks complete
On 05 Dec, 2020
Editor invited
On 03 Dec, 2020
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background
Human papillomavirus (HPV) infection can cause various HPV-related cancers and can be prevented through HPV vaccination. While vaccination coverage (proportion ever vaccinated) estimates are available, vaccination uptake (proportion getting their first vaccine dose in a specific year) in the United States (US) is not well-known.
Methods
We conducted a retrospective analysis of MarketScan® claims database to assess the HPV vaccination uptake in the US among the 9- to 26-years-olds from 2006 to 2016. The annual uptake was the ratio between the number of enrollees for whom a first record of an HPV vaccine was found during the year and the total number of unique enrollees of similar age and gender identified that year.
Results
Uptake was below 1% among children turning 9 and 10 years old during the year. Since 2009 among female and since 2013 among males, annual uptake has been the highest in those turning 13 years old (19.7% among females and 17.6% among males in 2016). Catch-up vaccination among older adolescents and young adults increased after Advisory Committee for Immunization Practices (ACIP) recommendations, but eventually slowed down as more younger persons were vaccinated. Most young adolescents were vaccinated by pediatricians, whereas young adult women were predominantly vaccinated by obstetricians/gynecologists and young adult males by family physicians. While only about half of the adolescents had well-check visits, majority of those who initiated HPV vaccination had at least one well-check visit the same year.
Conclusion
Understanding HPV vaccination uptake can guide the development of appropriate interventions to help improve public health.
Figure 1
Figure 2
This is a list of supplementary files associated with this preprint. Click to download.
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