Ethics approval and consent to participate
Protocols for the animal studies were approved by Stony Brook University’s Institutional Animal Care and Use Committee (IACUC #896357). Animals were housed in the Division of Laboratory Animal Resources (DLAR) at Stony Brook University, with care provided by the center’s personnel. All procedures were conducted at the same location. This facility follows the Animal Welfare Act (USDA enforced), the Public Health Service Act (OLAW enforced), and NY State law (DOH enforced), and is an AAALAC International accredited facility.
Consent for publication
Not applicable.
Availability of data and materials
The datasets used and/or analyzed during the current study are available from the corresponding author on reasonable request.
Competing interests
The authors declare that they have no competing interests.
Funding
This study was funded by NIDCR/NIH grant R42DE024946 and Traverse BioSciences, Inc.
Authors' contributions
Jie Deng was the principle experiment conductor, and had the substantial contributions to the acquisition, analysis, and interpretation of data, and was a major contributor in writing the manuscript. Lorne M. Golub, Hsi-Ming Lee and Ying Gu had the substantial contributions to the conception, design of the work, acquisition, interpretation of data and substantively revised the manuscript. Heta Dinesh Bhatt helped to perform the experiment, and had the contributions to the acquisition and data analysis. Hou-Lin Hong helped the statistical data analysis. Thomas Zimmerman is the chief of the Division of Laboratory Animal Resources (DLAR). He and his team performed the animal caring work and the general anaesthesia. Lorne M. Golub and Francis Johnson are also listed as the inventors on several related Patents, including CMC2.24. In addition, both Lorne M. Golub and Francis Johnson are minor shareholders in Traverse Biosciences, Inc., and Joseph Scaduto is the president and major shareholder in Traverse Biosciences Inc. They received grants from NIH/NIDCR (Phase II STTR Award 2R42DE024946-02) and from Traverse Biosciences Inc. Also, Traverse Biosciences Inc. has exclusively licensed patents from the Research Foundation for the State University of New York (RF/SUNY) covering the structure and use of the chemically-modified curcumins for the purpose of commercialization in human and animal health.
Acknowledgements
Authors would like to thank Michael Lin (Oral Biology and Pathology, Stony Brook University, New York, USA), Rachel Kogan (Department of Biology, Stony Brook University, New York, USA), Akshani Patel (Department of Biology, Stony Brook University, New York, USA), Tyler
Francisco (Department of Psychology, Stony Brook University, New York, USA), Kai-Xi Lin (Department of Pharmacology, Stony Brook University, New York, USA), Sandra Scherrer (
Veterinary Technician, DLAR, Stony Brook University, New York, USA) for their assistances to the dog study.