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Research article
Jie Qiu
Nanjing University Medical School
Corresponding Author
ORCiD: https://orcid.org/0000-0002-9680-135X
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This work is licensed under a CC BY 4.0 License. Read Full License
Background To evaluate effects of different positive end-expiratory pressure (PEEP) levels on cerebral hemodynamics of premature infants when using nasal continuous positive airway pressure (nCPAP) during the first 3 days of life.
Methods Forty-four preterm infants treated with nCPAP were divided into very preterm infant group (gestational age 1 (GA1) group, GA<32 weeks, n=24) and moderate and late preterm group (GA2 group, GA 32-37 weeks, n=20). During the monitoring process, the PEEP was set at 4→6→8→4 cmH 2 O and cerebral hemodynamics was assessed by near-infrared spectroscopy (NIRS). Life signs, peripheral oxygen saturation (SpO 2 ) and transcutaneous carbon dioxide pressure (TcPCO 2 ) were recorded at the same time.
Results Tissue oxygenation index (TOI), cerebral blood volume (△CBV) and the difference between oxygenated hemoglobin (△HbO 2 ) and deoxygenated hemoglobin (△HHb) (△HbD) were all significantly positive correlated with gestational and postnatal age and the fluctuation of GA1 group was greater. △CBV and △HbD were also significantly positive correlated with TcPCO 2 . PEEP of 4-8 cmH 2 O had no significant influence on cerebral hemodynamics, life signs, SpO 2 or TcPCO 2 .
Conclusions No significant differences were observed in cerebral hemodynamics when the PEEP was set from 4 to 8 cmH 2 O. These findings confirmed the safety and reliability of nCPAP at regular pressure levels to the nervous system of preterm infants.
Keywords
cerebral hemodynamics, nasal continuous positive airway pressure, near-infrared spectroscopy, positive end-expiratory pressure, preterm infant
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A new preprint design is coming!
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This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Research article
Jie Qiu
Nanjing University Medical School
Corresponding Author
ORCiD: https://orcid.org/0000-0002-9680-135X
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
History
CURRENT STATUS: Posted
View the published article at Frontiers in Pediatrics.
Version 1
Posted 25 Sep, 2019
No community comments so far
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Pediatrics
License:
This work is licensed under a CC BY 4.0 License. Read Full License
View the published article at Frontiers in Pediatrics.
Background To evaluate effects of different positive end-expiratory pressure (PEEP) levels on cerebral hemodynamics of premature infants when using nasal continuous positive airway pressure (nCPAP) during the first 3 days of life.
Methods Forty-four preterm infants treated with nCPAP were divided into very preterm infant group (gestational age 1 (GA1) group, GA<32 weeks, n=24) and moderate and late preterm group (GA2 group, GA 32-37 weeks, n=20). During the monitoring process, the PEEP was set at 4→6→8→4 cmH 2 O and cerebral hemodynamics was assessed by near-infrared spectroscopy (NIRS). Life signs, peripheral oxygen saturation (SpO 2 ) and transcutaneous carbon dioxide pressure (TcPCO 2 ) were recorded at the same time.
Results Tissue oxygenation index (TOI), cerebral blood volume (△CBV) and the difference between oxygenated hemoglobin (△HbO 2 ) and deoxygenated hemoglobin (△HHb) (△HbD) were all significantly positive correlated with gestational and postnatal age and the fluctuation of GA1 group was greater. △CBV and △HbD were also significantly positive correlated with TcPCO 2 . PEEP of 4-8 cmH 2 O had no significant influence on cerebral hemodynamics, life signs, SpO 2 or TcPCO 2 .
Conclusions No significant differences were observed in cerebral hemodynamics when the PEEP was set from 4 to 8 cmH 2 O. These findings confirmed the safety and reliability of nCPAP at regular pressure levels to the nervous system of preterm infants.
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