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Research article
Tomohiro Katagiri
Shizuoka city shizuoka hospital
Corresponding Author
ORCiD: https://orcid.org/0000-0002-4289-487X
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background
The prognosis of advanced oral cancer remains dismal. While multimodal therapy is beneficial, maintaining the quality of life of long-term survivors is important. Therefore, risk-adapted treatment regimens need to be designed. We herein investigated whether pathological responses in oral cancer patients treated with preoperative chemoradiotherapy predict locoregional recurrence.
Methods
We retrospectively reviewed the data of 51 oral cancer patients who received preoperative radiotherapy and concurrent pepleomycin, followed by curative surgery at our institution between January 2009 and June 2018. Each patient received preoperative external beam irradiation to the primary tumor and lymphatics (2 Gy per day for approximately 3 weeks) concurrent with pepleomycin (2.5 mg/day). Surgery was performed approximately 3–4 weeks after the completion of preoperative chemoradiotherapy. Pathological responses were defined based on the grading system of Oboshi and Shimosato.
Results
Eight, 22, 16, and 5 patients had Oboshi and Shimosato grades 2a, 2b, 3, and 4, respectively. Favorable pathological responses (grades 3 and 4) were observed in 41.2% of patients (21 out of 51 patients). The pathological response and number of pathological lymph node metastases were identified as significant prognostic factors for locoregional control in the univariate analysis. Three-year locoregional control rates were 100% and 56.6% in patients with favorable and unfavorable pathological responses, respectively.
Conclusions
The present study demonstrated that pathological tumor responses to preoperative chemoradiotherapy are a useful predictive factor for locoregional control.
Keywords
Oral cancer, preoperative chemoradiotherapy, pathological response
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CURRENT STATUS: Published
View the published article at BMC Cancer.
No community comments so far
Submission checks complete
On 03 Dec, 2020
Editorial decision: Accept
On 30 Nov, 2020
No comments provided
Reviewers invited
Invitations sent on 08 Nov, 2020
Editor assigned
On 02 Nov, 2020
Submission checks complete
On 02 Nov, 2020
Editor invited
On 02 Nov, 2020
Version 1
Posted 19 Aug, 2020
No comments provided
Reviewer #2 agreed
On 13 Oct, 2020
Review #2 received
Received 13 Oct, 2020
Editorial decision: Major revision
On 13 Oct, 2020
Review #1 received
Received 08 Oct, 2020
Reviewer #1 agreed
On 05 Sep, 2020
Reviewers invited
Invitations sent on 17 Aug, 2020
Editor assigned
On 09 Aug, 2020
Submission checks complete
On 08 Aug, 2020
Editor invited
On 08 Aug, 2020
First submitted
On 07 Aug, 2020
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PDF Downloads: ...
HTML Views: ...
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A new preprint design is coming!
We have improved readability, clarity, accessibility, and opportunities for engagement.
See the published version of this preprint at BMC Cancer.
This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research article
Tomohiro Katagiri
Shizuoka city shizuoka hospital
Corresponding Author
ORCiD: https://orcid.org/0000-0002-4289-487X
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Published
View the published article at BMC Cancer.
No community comments so far
Submission checks complete
On 03 Dec, 2020
Editorial decision: Accept
On 30 Nov, 2020
No comments provided
Reviewers invited
Invitations sent on 08 Nov, 2020
Editor assigned
On 02 Nov, 2020
Submission checks complete
On 02 Nov, 2020
Editor invited
On 02 Nov, 2020
Version 1
Posted 19 Aug, 2020
No comments provided
Reviewer #2 agreed
On 13 Oct, 2020
Review #2 received
Received 13 Oct, 2020
Editorial decision: Major revision
On 13 Oct, 2020
Review #1 received
Received 08 Oct, 2020
Reviewer #1 agreed
On 05 Sep, 2020
Reviewers invited
Invitations sent on 17 Aug, 2020
Editor assigned
On 09 Aug, 2020
Submission checks complete
On 08 Aug, 2020
Editor invited
On 08 Aug, 2020
First submitted
On 07 Aug, 2020
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
License:
This work is licensed under a CC BY 4.0 License. Read Full License
View the published article at BMC Cancer.
Background
The prognosis of advanced oral cancer remains dismal. While multimodal therapy is beneficial, maintaining the quality of life of long-term survivors is important. Therefore, risk-adapted treatment regimens need to be designed. We herein investigated whether pathological responses in oral cancer patients treated with preoperative chemoradiotherapy predict locoregional recurrence.
Methods
We retrospectively reviewed the data of 51 oral cancer patients who received preoperative radiotherapy and concurrent pepleomycin, followed by curative surgery at our institution between January 2009 and June 2018. Each patient received preoperative external beam irradiation to the primary tumor and lymphatics (2 Gy per day for approximately 3 weeks) concurrent with pepleomycin (2.5 mg/day). Surgery was performed approximately 3–4 weeks after the completion of preoperative chemoradiotherapy. Pathological responses were defined based on the grading system of Oboshi and Shimosato.
Results
Eight, 22, 16, and 5 patients had Oboshi and Shimosato grades 2a, 2b, 3, and 4, respectively. Favorable pathological responses (grades 3 and 4) were observed in 41.2% of patients (21 out of 51 patients). The pathological response and number of pathological lymph node metastases were identified as significant prognostic factors for locoregional control in the univariate analysis. Three-year locoregional control rates were 100% and 56.6% in patients with favorable and unfavorable pathological responses, respectively.
Conclusions
The present study demonstrated that pathological tumor responses to preoperative chemoradiotherapy are a useful predictive factor for locoregional control.
Figure 1
Figure 2
Figure 3
Figure 4
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