This preprint is under consideration at Journal of Ophthalmic Inflammation and Infection. A preprint is a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
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Original research
Ranju Kharel (Sitaula)
B.P. Koirala Lions Centre for Ophthalmic Studies, Institute of Medicine
Corresponding Author
ORCiD: https://orcid.org/0000-0001-8624-4433
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background: To assess the change in vision-related quality of life and psychosocial well-being of the patients with episcleritis and scleritis patients before and after treatment.
Results: This one-and-a-half-year prospective study was conducted among 76 eyes of 71 new patients of episcleritis and scleritis. A structured questionnaire was used to assess the visual and to analyze the change in effect size. The male-to-female ratio was 1:1.536. Episcleritis was seen in 41 cases (57.7%) while scleritis was seen in 30 cases (42.3%). Patients with episcleritis had statistically significant improvement in general function score (GF) (p<0.05) using paired t-test. The effect size showed medium improvement (approximately 0.5). Whereas there was no statistically significant change in psychosocial impact (PI), visual symptoms (VS) scoring, and a total score (p<0.05) using paired t-test. The effect size showed no improvement for PI and total score and small improvement for VS score. Patients with scleritis had statistically significant improvement in general function score (GF), visual symptoms (VS) scoring and total score (p<0.05) using paired-t-test. The effect size showed medium improvement (approximately 0.5) for general function score (GF) and total score. However, the effect size showed only a small improvement (approximately 0.2) for psychosocial impact (PI) score.
Conclusions: Vision Related Quality of Life of patients with scleritis showed significant improvement following treatment unlike episcleritis indicating scleritis more adversely affecting psychosocial well-being.
Keywords
Corticosteroids, Episcleritis, Quality of life, Scleritis, Visual function
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CURRENT STATUS: Under Review
Version 1
Posted 11 Jun, 2021
No community comments so far
Editorial decision: Minor Revision
On 11 Aug, 2021
Review #2 received
Received 10 Aug, 2021
Reviewer #2 agreed
On 28 Jul, 2021
Review #1 received
Received 12 Jul, 2021
Reviews received
Received 23 Jun, 2021
Reviewer #1 agreed
On 23 Jun, 2021
Reviewers invited
Invitations sent on 10 Jun, 2021
Submission checks complete
On 07 Jun, 2021
Editor invited
On 07 Jun, 2021
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On 07 Jun, 2021
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On 03 Jun, 2021
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A new preprint design is coming!
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This preprint is under consideration at Journal of Ophthalmic Inflammation and Infection. A preprint is a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Original research
Ranju Kharel (Sitaula)
B.P. Koirala Lions Centre for Ophthalmic Studies, Institute of Medicine
Corresponding Author
ORCiD: https://orcid.org/0000-0001-8624-4433
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Under Review
Version 1
Posted 11 Jun, 2021
No community comments so far
Editorial decision: Minor Revision
On 11 Aug, 2021
Review #2 received
Received 10 Aug, 2021
Reviewer #2 agreed
On 28 Jul, 2021
Review #1 received
Received 12 Jul, 2021
Reviews received
Received 23 Jun, 2021
Reviewer #1 agreed
On 23 Jun, 2021
Reviewers invited
Invitations sent on 10 Jun, 2021
Submission checks complete
On 07 Jun, 2021
Editor invited
On 07 Jun, 2021
Editor assigned
On 07 Jun, 2021
First submitted
On 03 Jun, 2021
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background: To assess the change in vision-related quality of life and psychosocial well-being of the patients with episcleritis and scleritis patients before and after treatment.
Results: This one-and-a-half-year prospective study was conducted among 76 eyes of 71 new patients of episcleritis and scleritis. A structured questionnaire was used to assess the visual and to analyze the change in effect size. The male-to-female ratio was 1:1.536. Episcleritis was seen in 41 cases (57.7%) while scleritis was seen in 30 cases (42.3%). Patients with episcleritis had statistically significant improvement in general function score (GF) (p<0.05) using paired t-test. The effect size showed medium improvement (approximately 0.5). Whereas there was no statistically significant change in psychosocial impact (PI), visual symptoms (VS) scoring, and a total score (p<0.05) using paired t-test. The effect size showed no improvement for PI and total score and small improvement for VS score. Patients with scleritis had statistically significant improvement in general function score (GF), visual symptoms (VS) scoring and total score (p<0.05) using paired-t-test. The effect size showed medium improvement (approximately 0.5) for general function score (GF) and total score. However, the effect size showed only a small improvement (approximately 0.2) for psychosocial impact (PI) score.
Conclusions: Vision Related Quality of Life of patients with scleritis showed significant improvement following treatment unlike episcleritis indicating scleritis more adversely affecting psychosocial well-being.
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