The treatment efficiency of Fenton reaction is expected to be greatly restricted due to problems such as inefficient delivery of Fenton catalysis, limited H 2 O 2 concentration and uneven tumour tissue. Accurate photothermal therapy (PTT) can to some extent improve the efficiency of Fenton catalysis by raising temperature. However, the heat shock response (HSR) of tumour cells caused by PTT and Fenton reaction can attenuate the treatment effect. In this study, we developed a combined treatment platform based on the Fenton reaction mediated by iron ions consisting of a metal organic framework, i.e., PPy-CTD@MIL-100@MPCM nanoparticles (PCMM NPs), and we explored the inhibitory effect of PCMM NPs on the heat shock response (HSR). PCMM NPs can be recruited into tumour tissues through the response of biomacromolecules on the surface of macrophage cell membranes (MPCMs) to tumour cell signaling molecules, thereby increasing retention and accumulation. The photothermal effect of polypyrrole (PPy) can stimulate the HSR of tumour, and loaded HSP inhibitor-cantharidin (CTD) can inhibit this response to a large extent. In addition, the heat generated during the PTT process can accelerate the release of iron ions from the PCMM NPs and simultaneously improve the efficiency of the Fenton reaction to achieve a combined treatment of tumour PTT, Fenton therapy and chemotherapy.
