To study the impact of protection and hospital quarantine measure, government pre-warning mechanism and heterogeneity of underlying networks on epidemic spreading, a novel SEAIRS epidemic model is proposed on scale-free networks. The spreading dynamics of the model is studied by means of the mean-field theory. Two equilibriums and the basic reproductive number R0 of the model is analyzed in detail. The global asymptotic stability of the disease-free equilibrium, the permanence of the epidemic spreading and the global attractivity of the endemic equilibrium are proved. Sensitivity analysis shows that the basic reproductive number R0 is dependent on the coverage rate of home quarantine (ωQ,ηA ,ηS ), hospitalization rate η1 and government pre-warning intensity δ . Finally, the theoretical analysis results are confirmed by means of numerical simulations.