Analysis of IL-1β, CXCL8, and TNF-α levels in the crevicular fluid of patients with periodontitis or healthy implants
Background: Our study aimed to assess the level of IL-1β, CXCL8, and TNF-α in peri-implant sulcular fluid (PISF) collected from patients with no clinical symptoms of mucositis or peri-implantitis and compare them with cytokine concentration in gingival crevicular fluid (GCF) acquired from patients with healthy periodontium and those with varying severity of periodontitis.
Methods: A total of 189 subjects were included in the study, and GCF/PISF samples were checked for IL-1β, CXCL8, and TNF-α levels using an ELISA test.
Results: The IL-1β level in PISF in patients with implants was significantly lower than in GCF in patients with mild, moderate, or severe periodontitis. The CXCL8 level in PISF was considerably lower than in patients with moderate periodontitis. The TNF-α level in PISF in patients with implants was markedly higher compared to subjects with healthy periodontium or patients with mild periodontitis.
Conclusion: Analysis of cytokine levels may help describe the pathogenesis and early diagnosis of peri-implantitis and prevision in high-risk patients.
On 17 Jan, 2021
On 13 Jan, 2021
On 13 Jan, 2021
On 13 Jan, 2021
Posted 12 Jan, 2021
On 29 Dec, 2020
On 25 Dec, 2020
On 25 Dec, 2020
On 25 Dec, 2020
Received 15 Dec, 2020
On 15 Dec, 2020
On 25 Nov, 2020
Invitations sent on 23 Nov, 2020
On 16 Nov, 2020
On 16 Nov, 2020
On 16 Nov, 2020
Received 18 Oct, 2020
On 18 Oct, 2020
Received 05 Oct, 2020
Invitations sent on 14 Sep, 2020
On 14 Sep, 2020
On 14 Sep, 2020
On 13 Sep, 2020
On 05 Sep, 2020
On 04 Sep, 2020
On 12 Aug, 2020
Analysis of IL-1β, CXCL8, and TNF-α levels in the crevicular fluid of patients with periodontitis or healthy implants
On 17 Jan, 2021
On 13 Jan, 2021
On 13 Jan, 2021
On 13 Jan, 2021
Posted 12 Jan, 2021
On 29 Dec, 2020
On 25 Dec, 2020
On 25 Dec, 2020
On 25 Dec, 2020
Received 15 Dec, 2020
On 15 Dec, 2020
On 25 Nov, 2020
Invitations sent on 23 Nov, 2020
On 16 Nov, 2020
On 16 Nov, 2020
On 16 Nov, 2020
Received 18 Oct, 2020
On 18 Oct, 2020
Received 05 Oct, 2020
Invitations sent on 14 Sep, 2020
On 14 Sep, 2020
On 14 Sep, 2020
On 13 Sep, 2020
On 05 Sep, 2020
On 04 Sep, 2020
On 12 Aug, 2020
Background: Our study aimed to assess the level of IL-1β, CXCL8, and TNF-α in peri-implant sulcular fluid (PISF) collected from patients with no clinical symptoms of mucositis or peri-implantitis and compare them with cytokine concentration in gingival crevicular fluid (GCF) acquired from patients with healthy periodontium and those with varying severity of periodontitis.
Methods: A total of 189 subjects were included in the study, and GCF/PISF samples were checked for IL-1β, CXCL8, and TNF-α levels using an ELISA test.
Results: The IL-1β level in PISF in patients with implants was significantly lower than in GCF in patients with mild, moderate, or severe periodontitis. The CXCL8 level in PISF was considerably lower than in patients with moderate periodontitis. The TNF-α level in PISF in patients with implants was markedly higher compared to subjects with healthy periodontium or patients with mild periodontitis.
Conclusion: Analysis of cytokine levels may help describe the pathogenesis and early diagnosis of peri-implantitis and prevision in high-risk patients.