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Research Article
Qian Chu
Department of Oncology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China.
Corresponding Author
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background: The novel coronavirus (COVID-19)–infected pneumonia is an international concern as it spreads through human populations and across national and international borders.
Methods: In this retrospective study, we consecutively included all cancer cases who had been identified as having a nucleic acid-confirmed COVID-19 infection from two designated hospitals in Wuhan, China. Non-cancer patients were also enrolled for comparison. The clinical data were gathered from the medical recordsfrom Jan 14 to March 12.
Results: Among the 117 cancer patients infected with COVID19, the median age was 63 years and 48.7% were male. Male, hematologic cancer, dyspnea on admission, and anti-cancer therapy significantly increased the risk of death. The amounts of cytokines and immune cells were correlated with the outcomeofcancer patients infected with COVIP-19. However, high level of TNF-a, IL-2R, IL-6, IL-8 did not increase the risk of death in non-cancer patients. Moreover, IL-2R and IL-6 markedly decreased in cancer patients recovered from COVID-19.
Conclusions: Cancer patients with COVID-19 were associated with high mortality (23.9%).The amounts of cytokines and lymphocytes could be utilized as the reference index in predicting the survival outcome of cancer patients with COVID-19.
Keywords
COVID-19, cancer, survival time, cytokines, lymphocytes
Figure 1
Figure 2
Figure 3
This is a list of supplementary files associated with this preprint. Click to download.
- Supplementalfigure1.tif
Supplemental figure 1. Serum cytokines on admission of non-cancer patients.Levels of TNF-, IL-2R, IL-6, IL-8, and IL-10 were increased in non-cancer patients died of COVID-19 (A). The association between cytokines with survival time in non-cancer patients with COVID-19 (B).
- Supplementaltable1.docx
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This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Research Article
Qian Chu
Department of Oncology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China.
Corresponding Author
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
History
CURRENT STATUS: Posted
Version 1
Posted 14 Aug, 2020
No community comments so far
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Cancer Biology
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background: The novel coronavirus (COVID-19)–infected pneumonia is an international concern as it spreads through human populations and across national and international borders.
Methods: In this retrospective study, we consecutively included all cancer cases who had been identified as having a nucleic acid-confirmed COVID-19 infection from two designated hospitals in Wuhan, China. Non-cancer patients were also enrolled for comparison. The clinical data were gathered from the medical recordsfrom Jan 14 to March 12.
Results: Among the 117 cancer patients infected with COVID19, the median age was 63 years and 48.7% were male. Male, hematologic cancer, dyspnea on admission, and anti-cancer therapy significantly increased the risk of death. The amounts of cytokines and immune cells were correlated with the outcomeofcancer patients infected with COVIP-19. However, high level of TNF-a, IL-2R, IL-6, IL-8 did not increase the risk of death in non-cancer patients. Moreover, IL-2R and IL-6 markedly decreased in cancer patients recovered from COVID-19.
Conclusions: Cancer patients with COVID-19 were associated with high mortality (23.9%).The amounts of cytokines and lymphocytes could be utilized as the reference index in predicting the survival outcome of cancer patients with COVID-19.
Figure 1
Figure 2
Figure 3
This is a list of supplementary files associated with this preprint. Click to download.
- Supplementalfigure1.tif
Supplemental figure 1. Serum cytokines on admission of non-cancer patients.Levels of TNF-, IL-2R, IL-6, IL-8, and IL-10 were increased in non-cancer patients died of COVID-19 (A). The association between cytokines with survival time in non-cancer patients with COVID-19 (B).
- Supplementaltable1.docx
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