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Research
Joanna Jerzyńska
Uniwersytet Medyczny w Lodzi
Corresponding Author
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Background: MAS study revealed that chronic course of asthma characterized by airway hyper-responsiveness and impairment of lung function at school age is determined by continuing allergic airway inflammation which begin in the first 3 years of life. Respiratory tract infections early in life, childhood allergic comorbidities, exposure to environmental determinants of asthma and active smoking may all contribute to increased risk of allergic disorders. While these correlations have been established, there is little understanding of the immunological mechanisms by which asthma develops into a persistent disease, or by which symptoms regress.
Methods. Eighty patients were included into the analysis. Clinical and immunoregulatory predictors of asthma were analyzed.
Results: Presence of mAPI criteria as well as house dust mite-allergy and allergic rhinitis at 7-10 yeas, were associated with a reduced prevalence of asthma remission. The increased eosinophil blood count in API (Asthma Predictive Index) criteria was associated with a lower expression of CD25 positive cells. Current HDM-allergy was associated with a higher FeNO level and higher expression of CD25CD71 positive cells. Allergic rhinitis was associated with a higher expression of PPAR and CD25CD71 positive cells; in the same group of patients a lower expression of GARP positive cells were observed.
Conclusions: Probability of persistence of childhood asthma was largely determined by the presence of allergic rhinitis and sensitization to HDM. Our results suggest natural remission of clinical symptoms of asthma in children are not fully related to immunoregulation processes. Additionally, API criteria are related to asthma persistence.
Keywords
children, asthma persistence, allergic rhinitis, house dust mite sensitization
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This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Research
Joanna Jerzyńska
Uniwersytet Medyczny w Lodzi
Corresponding Author
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
History
CURRENT STATUS: Posted
Version 2
Posted 18 Dec, 2020
No community comments so far
No comments provided
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Allergy & Immune Disorders
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background: MAS study revealed that chronic course of asthma characterized by airway hyper-responsiveness and impairment of lung function at school age is determined by continuing allergic airway inflammation which begin in the first 3 years of life. Respiratory tract infections early in life, childhood allergic comorbidities, exposure to environmental determinants of asthma and active smoking may all contribute to increased risk of allergic disorders. While these correlations have been established, there is little understanding of the immunological mechanisms by which asthma develops into a persistent disease, or by which symptoms regress.
Methods. Eighty patients were included into the analysis. Clinical and immunoregulatory predictors of asthma were analyzed.
Results: Presence of mAPI criteria as well as house dust mite-allergy and allergic rhinitis at 7-10 yeas, were associated with a reduced prevalence of asthma remission. The increased eosinophil blood count in API (Asthma Predictive Index) criteria was associated with a lower expression of CD25 positive cells. Current HDM-allergy was associated with a higher FeNO level and higher expression of CD25CD71 positive cells. Allergic rhinitis was associated with a higher expression of PPAR and CD25CD71 positive cells; in the same group of patients a lower expression of GARP positive cells were observed.
Conclusions: Probability of persistence of childhood asthma was largely determined by the presence of allergic rhinitis and sensitization to HDM. Our results suggest natural remission of clinical symptoms of asthma in children are not fully related to immunoregulation processes. Additionally, API criteria are related to asthma persistence.
Figure 1
This is a list of supplementary files associated with this preprint. Click to download.
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