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Research article
Kenneth NK Fong
Hong Kong Polytechnic University Faculty of Health and Social Sciences
Corresponding Author
ORCiD: https://orcid.org/0000-0001-5909-4847
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background: The potential benefits of priming intermittent theta burst stimulation (iTBS) with continuous theta burst stimulation (cTBS) have not been examined in regard to sensorimotor oscillatory activities recorded in electroencephalography (EEG).
Objective: The objective of this study was to investigate the modulatory effect of priming iTBS (cTBS followed by iTBS) delivered to the motor cortex on movement-related and mirror visual feedback (MVF)-induced sensorimotor event-related desynchronization (ERD), compared with iTBS alone, on healthy adults.
Methods: Twenty participants were randomly allocated into Group 1: priming iTBS - cTBS followed by iTBS, and Group 2: non-priming iTBS - sham cTBS followed by iTBS. The stimulation was delivered to the right motor cortex daily for 4 consecutive days. EEG was measured before and after 4 sessions of stimulation. Movement-related ERD was evaluated during left-index finger tapping and MVF-induced sensorimotor ERD was evaluated by comparing the difference between right-index finger tapping with and without MVF.
Results: After stimulation, both protocols increased movement-related ERD and MVF-induced sensorimotor ERD in high mu and low beta bands, indicated by significant time effects. A significant interaction effect favoring Group 1 in enhancing movement-related ERD was observed in the high mu band (F (1, 18) = 4.47, p = 0.049), compared with Group 2.
Conclusion: Our experiment suggests that priming iTBS with cTBS delivered to the motor cortex yields similar effects with iTBS alone on enhancing sensorimotor activation induced by movement and MVF-based observation on healthy adults. Further studies are warranted.
Keywords
Theta burst stimulation, event-related desynchronization, metaplasticity, motor cortex, mirror visual feedback
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This is a preprint. It has not completed peer review.
Research article
Kenneth NK Fong
Hong Kong Polytechnic University Faculty of Health and Social Sciences
Corresponding Author
ORCiD: https://orcid.org/0000-0001-5909-4847
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
History
CURRENT STATUS: Posted
Version 1
Posted 24 Aug, 2020
No community comments so far
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background: The potential benefits of priming intermittent theta burst stimulation (iTBS) with continuous theta burst stimulation (cTBS) have not been examined in regard to sensorimotor oscillatory activities recorded in electroencephalography (EEG).
Objective: The objective of this study was to investigate the modulatory effect of priming iTBS (cTBS followed by iTBS) delivered to the motor cortex on movement-related and mirror visual feedback (MVF)-induced sensorimotor event-related desynchronization (ERD), compared with iTBS alone, on healthy adults.
Methods: Twenty participants were randomly allocated into Group 1: priming iTBS - cTBS followed by iTBS, and Group 2: non-priming iTBS - sham cTBS followed by iTBS. The stimulation was delivered to the right motor cortex daily for 4 consecutive days. EEG was measured before and after 4 sessions of stimulation. Movement-related ERD was evaluated during left-index finger tapping and MVF-induced sensorimotor ERD was evaluated by comparing the difference between right-index finger tapping with and without MVF.
Results: After stimulation, both protocols increased movement-related ERD and MVF-induced sensorimotor ERD in high mu and low beta bands, indicated by significant time effects. A significant interaction effect favoring Group 1 in enhancing movement-related ERD was observed in the high mu band (F (1, 18) = 4.47, p = 0.049), compared with Group 2.
Conclusion: Our experiment suggests that priming iTBS with cTBS delivered to the motor cortex yields similar effects with iTBS alone on enhancing sensorimotor activation induced by movement and MVF-based observation on healthy adults. Further studies are warranted.
Figure 1
Figure 2
Figure 3
Figure 4
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