Ethics approval and consent to participate
All study participants provided an written informed consent to participate. The national council on statistical information (CNIL) approved the CONSTANCES study before it began (CNIL authorisation n°910,486), as well as an additional related application CNIL authorisation n°1,881,675).CONSTANCES was approved by the National Council for Statistical Information (Conseil national de l’information statistique-CNIS), the National Medical Council (Conseil national de l’Ordre des médecins-CNOM), the Institutional Review Board of the National Institute for Medical Research (INSERM) and our local Committee for Persons Protection (Comité de protection des personnes).
Consent for publication
Not applicable.
Availability of data and materials
Data and material are available from [email protected]
Competing interests
The authors declare that they have no competing interests.
Funding
No funding was given for this study. The French CONSTANCES cohort is supported by the French National Research Agency (ANR-11-INBS-0002), Caisse Nationale d’Assurance Maladie des travailleurs salariés-CNAMTS, and is funded by the Institut de Recherche en Santé Publique/Institut Thématique Santé Publique, and the following sponsors: Ministère de la santé et des sports, Ministère délégué à la recherche, Institut national de la santé et de la recherche médicale, Institut national du cancer et Caisse nationale de solidarité pour l’autonomie, as well as Institute for research in public health (IReSP, CapaciT project).
Authors’ contribution: Conceptualization: SM, XF, VR, SV, MZ. Formal analysis: SM, VR, SV,XF, MZ; Methodology: SM, VR, HP, XF. Data collection and analyses: SM. Statistical analyses: SM, HP; Visualization: SM, P-JS, XF, VR ; Writing : SM, VR, XF, SV, P-JS, MZ. Supervision: XF, VR.
Acknowledgments
The authors thank the Inserm-Versailles Saint Quentin en Yvelines University “Epidemiological Population-Based Cohorts Unit” (UMS 011) who designed and is in charge of the CONSTANCES Cohort Study. They also thank the “Caisse nationale d’assurance maladie des travailleurs salaries” (CNAMTS) and the “Centres d’examens de santé » of the French Social Security which are collecting a large part of the data, as well as the “Caisse nationale d’assurance vieillesse”, ClinSearch, Asqualab and Eurocell in charge of the data quality control.
The CONSTANCES Cohort Study was funded by the Caisse nationale d’assurance maladie des travailleurs salaries (CNAMTS), the Ministry of Health, the Council of the Ile de France Region, and by the Cohorts TGIR IReSP-ISP INSERM (Ministère de la santé et des sports, Ministère délégué à la recherche, Institut national de la santé et de la recherche médicale, Institut national du cancer et Caisse nationale de solidarité pour l'autonomie). The CONSTANCES Cohort Study is an « Infrastructure nationale en Biologie et Santé » and benefits from a grant from ANR (ANR-11-INBS-0002).
fottnotes
[1] This methods is a so-called "natural" calendar-based contraceptive method, better known as the rhythm method, which involves avoiding sexual intercourse during the period when the woman can become pregnant.