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Effects of non-surgical periodontal therapy on systemic inflammation and metabolic markers in patients undergoing haemodialysis and/or peritoneal dialysis: a systematic review and meta-analysis
Bo Hu
Corresponding Author
ORCiD: https://orcid.org/0000-0002-4641-1468
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This work is licensed under a CC BY 4.0 License. Read Full License
View the published version at BMC Oral Health.
Background: This systematic review aimed to investigate whether non-surgical periodontal therapy (NSPT) can reduce systemic inflammatory levels and improve metabolism in patients undergoing haemodialysis (HD) and/or peritoneal dialysis (PD). Methods: Electronic databases (PubMed, EMBASE, CENTRAL, CNKI, and WFPD) were searched for randomized controlled trials (RCTs) performed through July 2019. The risk of bias within studies was assessed with the Cochrane Collaboration’s risk assessment tool. The systemic inflammatory and metabolic outcomes included the highly sensitive C-reactive protein (hs-CRP), interleukin 6 (IL-6), tumour necrosis factor-a (TNF-a), the albumin (Alb), and lipid metabolite levels Meta-analyses (MAs) were performed to calculate the overall effect size where appropriate. Results: Five RCTs were included in this study. Compared with untreated periodontitis groups, the dialysis patients after NSPT significantly showed decreased hs-CRP levels at less than or equal to 2 months (standardized mean difference: -1.53, 95% confidence interval -2.95 to -0.11). No significant difference was found in IL-6 and Alb levels following NSPT at either the 3- or 6- month follow-ups. No MAs could be performed on the TNF-a level and the lipid metabolic markers. Conclusions: NSPT can moderately reduce serum hs-CRP levels in HD and/or PD patients, but did not significantly change IL-6 or Alb levels. For TNF-a and lipid metabolism markers, no sufficient evidence supports that these levels are changed after NSPT. Additional scientific research is necessary to assess the effects of NSPT on systemic inflammation and metabolic parameters in dialysis patients.
Keywords
End-stage renal disease, Haemodialysis, Peritoneal dialysis, Non-surgical periodontal treatment
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CURRENT STATUS: Published
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Posted 10 Jan, 2020
Published
On 22 Jan, 2020
No community comments so far
Editorial decision: Accept
On 10 Jan, 2020
Editor assigned
On 07 Jan, 2020
Submission checks complete
On 06 Jan, 2020
Editor invited
On 06 Jan, 2020
No comments provided
Editorial decision: Minor revision
On 26 Dec, 2019
Review #2 received
Received 13 Dec, 2019
Review #1 received
Received 07 Dec, 2019
Reviewer #2 agreed
On 03 Dec, 2019
Reviewers invited
Invitations sent on 28 Nov, 2019
Reviewer #1 agreed
On 28 Nov, 2019
Editor assigned
On 27 Nov, 2019
Submission checks complete
On 26 Nov, 2019
Editor invited
On 26 Nov, 2019
No comments provided
Editorial decision: Major revision
On 27 Oct, 2019
Review #2 received
Received 25 Oct, 2019
Review #1 received
Received 23 Oct, 2019
Reviewer #2 agreed
On 13 Oct, 2019
Reviewer #1 agreed
On 05 Oct, 2019
Reviewers invited
Invitations sent on 04 Oct, 2019
Editor assigned
On 23 Sep, 2019
Submission checks complete
On 22 Sep, 2019
Editor invited
On 22 Sep, 2019
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This preprint is under consideration at BMC Oral Health. A preprint is a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research article
Effects of non-surgical periodontal therapy on systemic inflammation and metabolic markers in patients undergoing haemodialysis and/or peritoneal dialysis: a systematic review and meta-analysis
Bo Hu
Corresponding Author
ORCiD: https://orcid.org/0000-0002-4641-1468
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Published
Version 3
Posted 10 Jan, 2020
Published
On 22 Jan, 2020
No community comments so far
Editorial decision: Accept
On 10 Jan, 2020
Editor assigned
On 07 Jan, 2020
Submission checks complete
On 06 Jan, 2020
Editor invited
On 06 Jan, 2020
No comments provided
Editorial decision: Minor revision
On 26 Dec, 2019
Review #2 received
Received 13 Dec, 2019
Review #1 received
Received 07 Dec, 2019
Reviewer #2 agreed
On 03 Dec, 2019
Reviewers invited
Invitations sent on 28 Nov, 2019
Reviewer #1 agreed
On 28 Nov, 2019
Editor assigned
On 27 Nov, 2019
Submission checks complete
On 26 Nov, 2019
Editor invited
On 26 Nov, 2019
No comments provided
Editorial decision: Major revision
On 27 Oct, 2019
Review #2 received
Received 25 Oct, 2019
Review #1 received
Received 23 Oct, 2019
Reviewer #2 agreed
On 13 Oct, 2019
Reviewer #1 agreed
On 05 Oct, 2019
Reviewers invited
Invitations sent on 04 Oct, 2019
Editor assigned
On 23 Sep, 2019
Submission checks complete
On 22 Sep, 2019
Editor invited
On 22 Sep, 2019
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
License:
This work is licensed under a CC BY 4.0 License. Read Full License
View the published version at BMC Oral Health.
Background: This systematic review aimed to investigate whether non-surgical periodontal therapy (NSPT) can reduce systemic inflammatory levels and improve metabolism in patients undergoing haemodialysis (HD) and/or peritoneal dialysis (PD). Methods: Electronic databases (PubMed, EMBASE, CENTRAL, CNKI, and WFPD) were searched for randomized controlled trials (RCTs) performed through July 2019. The risk of bias within studies was assessed with the Cochrane Collaboration’s risk assessment tool. The systemic inflammatory and metabolic outcomes included the highly sensitive C-reactive protein (hs-CRP), interleukin 6 (IL-6), tumour necrosis factor-a (TNF-a), the albumin (Alb), and lipid metabolite levels Meta-analyses (MAs) were performed to calculate the overall effect size where appropriate. Results: Five RCTs were included in this study. Compared with untreated periodontitis groups, the dialysis patients after NSPT significantly showed decreased hs-CRP levels at less than or equal to 2 months (standardized mean difference: -1.53, 95% confidence interval -2.95 to -0.11). No significant difference was found in IL-6 and Alb levels following NSPT at either the 3- or 6- month follow-ups. No MAs could be performed on the TNF-a level and the lipid metabolic markers. Conclusions: NSPT can moderately reduce serum hs-CRP levels in HD and/or PD patients, but did not significantly change IL-6 or Alb levels. For TNF-a and lipid metabolism markers, no sufficient evidence supports that these levels are changed after NSPT. Additional scientific research is necessary to assess the effects of NSPT on systemic inflammation and metabolic parameters in dialysis patients.
Figure 1
Figure 2
Figure 3
Figure 4
Figure 5