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Research Article
Majid Abdouss
Amirkabir University of Technology
Corresponding Author
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Chitosan is a linear polysaccharide with and prominent physicochemical and biological properties such as biocompatibility, biodegradability, nontoxicity, non-immunogenicity, bioadhesion, antibacterial, antifungal and hemostatic activity. Due to these properties, it has found many applications in cosmetic, textile, and food industries; agriculture; biotechnology; pharmaceutical industry and medicine; specially in biomedical applications. The special chemical structure of chitosan allows some specific modifications and by reducing the size of chitosan particles to Nano size, it becomes an excellent drug nanocarrier. Vancomycin is a typical antibiotic used for bacterial infections caused by geram positive bacteria. In this work, chitosan nanoparticles (CSNPs) were prepared via ionotropic gelation using tripolyphosphate (TPP) as crosslinker. The effect of chitosan and TPP concentration on the size of chitosan nanoparticles was studied and CS:TPP ratio of 1:1 with average size of nanoparticle about 100 nm were selected. The prepared samples were characterized using DLS, FTIR, TGA, DSC, and SEM techniques. The results confirmed that vancomycin has been loaded successfully on chitosan nanoparticles and there was not any interaction between vancomycin and chitosan. Also, it is observed that 40% of vancomycin is released burstly in the first 9 h and after that the drug release is continued gradually to receive 90% at 100 h.
Keywords
drug release, vancomycin, chitosan nanoparticles, crosslinker
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- Scheme1.png
Scheme 1. The chemical structure of vancomycin [19].
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This preprint is under consideration at Journal of Polymers and the Environment. A preprint is a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research Article
Majid Abdouss
Amirkabir University of Technology
Corresponding Author
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Under Review
Version 1
Posted 08 Jul, 2021
No community comments so far
Editor assigned
On 08 Jun, 2021
First submitted
On 05 Jun, 2021
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Chitosan is a linear polysaccharide with and prominent physicochemical and biological properties such as biocompatibility, biodegradability, nontoxicity, non-immunogenicity, bioadhesion, antibacterial, antifungal and hemostatic activity. Due to these properties, it has found many applications in cosmetic, textile, and food industries; agriculture; biotechnology; pharmaceutical industry and medicine; specially in biomedical applications. The special chemical structure of chitosan allows some specific modifications and by reducing the size of chitosan particles to Nano size, it becomes an excellent drug nanocarrier. Vancomycin is a typical antibiotic used for bacterial infections caused by geram positive bacteria. In this work, chitosan nanoparticles (CSNPs) were prepared via ionotropic gelation using tripolyphosphate (TPP) as crosslinker. The effect of chitosan and TPP concentration on the size of chitosan nanoparticles was studied and CS:TPP ratio of 1:1 with average size of nanoparticle about 100 nm were selected. The prepared samples were characterized using DLS, FTIR, TGA, DSC, and SEM techniques. The results confirmed that vancomycin has been loaded successfully on chitosan nanoparticles and there was not any interaction between vancomycin and chitosan. Also, it is observed that 40% of vancomycin is released burstly in the first 9 h and after that the drug release is continued gradually to receive 90% at 100 h.
Figure 1
Figure 2
Figure 3
Figure 4
Figure 5
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Figure 9
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