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Research article
Predicting Visual Acuity in Bietti Crystalline Dystrophy: Evaluation of Image Parameters
Nan-Kai Wang
Chang Gung Memorial Hospital Linkou Branch
Corresponding Author
ORCiD: https://orcid.org/0000-0002-6277-9879
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background: To analyze multiple imaging modalities in patients with Bietti crystalline dystrophy (BCD) and to investigate which factors from these modalities are associated with best corrected visual acuity (BCVA).
Methods: In this prospective observational study, the eyes were separated into group 1 (BCVA £ 20/200) and group 2 (BCVA > 20/200). Data including BCVA and characteristic findings from near-infrared reflectance (NIR) imaging, fundus autofluorescence (FAF), and spectral domain-optic coherence tomography (SD-OCT) were analyzed and compared. The outcome measures of multimodal imaging were evaluated for correlation with BCVA.
Results: NIR is a good diagnostic tool for detecting either crystalline or sclerotic vessels in BCD. Patients in group 1 tended to have a thinner choroid (P = 0.047) with ellipsoid zone (EZ) disruption (P = 0.011). Calculation of the area under the curve indicated that EZ disruption detected on SD-OCT could be a good predictor of legal blindness in BCD.
Conclusion: For the diagnosis of BCD, NIR could be a good diagnostic tool. Of the studied imaging modalities, we found that EZ disruption at the fovea were strongly associated with legal blindness, which could be easily assessed by SD-OCT.
Trial registration: Retrospectively registered.
Keywords
best corrected visual acuity (BCVA), Bietti crystalline dystrophy (BCD), choroidal thickness, crystalline, ellipsoid zone disruption, fundus autofluorescence (FAF), near-infrared reflectance (NIR), sclerotic vessels, spectral domain-optic coherence tomography (SD-OCT)
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CURRENT STATUS: Under Review
Version (no preprint)
Posted 04 Jan, 2021
Editorial decision: Minor revision
On 04 Jan, 2021
Editor assigned
On 03 Jan, 2021
Submission checks complete
On 03 Jan, 2021
Editor invited
On 03 Jan, 2021
This version was not preprinted
Version 1
Posted 25 Sep, 2020
No community comments so far
Reviewer #3 agreed
On 04 Dec, 2020
Review #3 received
Received 04 Dec, 2020
Review #2 received
Received 04 Dec, 2020
Review #1 received
Received 03 Dec, 2020
Reviewer #2 agreed
On 03 Dec, 2020
Reviewer #1 agreed
On 21 Nov, 2020
Reviewers invited
Invitations sent on 29 Oct, 2020
Editor assigned
On 23 Sep, 2020
Submission checks complete
On 22 Sep, 2020
Editor invited
On 22 Sep, 2020
Version (no preprint)
Posted 15 Aug, 2020
This version was not preprinted
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Subject Areas
Ophthalmology
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This preprint is under consideration at BMC Ophthalmology. A preprint is a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research article
Predicting Visual Acuity in Bietti Crystalline Dystrophy: Evaluation of Image Parameters
Nan-Kai Wang
Chang Gung Memorial Hospital Linkou Branch
Corresponding Author
ORCiD: https://orcid.org/0000-0002-6277-9879
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Under Review
Version (no preprint)
Posted 04 Jan, 2021
Editorial decision: Minor revision
On 04 Jan, 2021
Editor assigned
On 03 Jan, 2021
Submission checks complete
On 03 Jan, 2021
Editor invited
On 03 Jan, 2021
This version was not preprinted
Version 1
Posted 25 Sep, 2020
No community comments so far
Reviewer #3 agreed
On 04 Dec, 2020
Review #3 received
Received 04 Dec, 2020
Review #2 received
Received 04 Dec, 2020
Review #1 received
Received 03 Dec, 2020
Reviewer #2 agreed
On 03 Dec, 2020
Reviewer #1 agreed
On 21 Nov, 2020
Reviewers invited
Invitations sent on 29 Oct, 2020
Editor assigned
On 23 Sep, 2020
Submission checks complete
On 22 Sep, 2020
Editor invited
On 22 Sep, 2020
Version (no preprint)
Posted 15 Aug, 2020
This version was not preprinted
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Ophthalmology
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background: To analyze multiple imaging modalities in patients with Bietti crystalline dystrophy (BCD) and to investigate which factors from these modalities are associated with best corrected visual acuity (BCVA).
Methods: In this prospective observational study, the eyes were separated into group 1 (BCVA £ 20/200) and group 2 (BCVA > 20/200). Data including BCVA and characteristic findings from near-infrared reflectance (NIR) imaging, fundus autofluorescence (FAF), and spectral domain-optic coherence tomography (SD-OCT) were analyzed and compared. The outcome measures of multimodal imaging were evaluated for correlation with BCVA.
Results: NIR is a good diagnostic tool for detecting either crystalline or sclerotic vessels in BCD. Patients in group 1 tended to have a thinner choroid (P = 0.047) with ellipsoid zone (EZ) disruption (P = 0.011). Calculation of the area under the curve indicated that EZ disruption detected on SD-OCT could be a good predictor of legal blindness in BCD.
Conclusion: For the diagnosis of BCD, NIR could be a good diagnostic tool. Of the studied imaging modalities, we found that EZ disruption at the fovea were strongly associated with legal blindness, which could be easily assessed by SD-OCT.
Trial registration: Retrospectively registered.
Figure 1
Figure 2
Figure 3
Figure 4
Figure 5
Figure 6