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Research
Ki Young Son
Asan Medical Center, University of Ulsan College of Medicine
Corresponding Author
ORCiD: https://orcid.org/0000-0003-1262-100X
License:
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Background
Dyslipidemia is an independent health risk of cardiovascular disease (CVD), a leading cause of mortality in older adults. Despite their importance, there have been few reports on the association between lipoprotein cholesterol and future CVD and cardiovascular (CV) mortality among elderly Asians. This longitudinal study investigated the correlations in an elderly Korean population by using a large nationwide sample.
Methods
Among participants in the cohort database of the Korean National Health Insurance Service who completed the National Screening Program, a total of 62,604 adults aged 65 years or older (32,584 men and 30,020 women) were included. High-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C) values were categorized by quartiles. Cox proportional hazard models were used to assess the association between the quartiles of lipoprotein cholesterol and CV events or CV mortality.
Results
The mean follow-up period was 3.3 years. The incidence rates of ischemic heart disease and ischemic brain disease were 0.97 and 0.61 per 1,000 person-years, while the mortality rates from these diseases were 0.22 and 0.34 per 1,000 person-years, respectively. In a fully adjusted model, high HDL-C and LDL-C levels were not associated with the total CV events and CV mortality; however, high LDL-C levels were significantly associated with a lower incidence of ischemic brain disease. Furthermore, diabetic patients with high LDL-C were more likely to have higher CV mortality, whereas non-smokers with high LDL-C were less likely to be at risk of CV events.
Conclusions
Neither high LDL-C nor HDL-C was significantly associated with future CV mortality in older adults aged ≥65 years. Older adults with diabetes were significantly associated with a higher risk of CV mortality in high LDL-C levels.
Keywords
Lipoprotein cholesterol, Cardiovascular disease, Relationship, Elderly, Mortality
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CURRENT STATUS: Published
View the published article at Lipids in Health and Disease.
No community comments so far
Editorial decision: Accept
On 03 Dec, 2020
Editor assigned
On 22 Nov, 2020
Reviewers invited
Invitations sent on 22 Nov, 2020
Submission checks complete
On 22 Nov, 2020
Editor invited
On 22 Nov, 2020
Version (no preprint)
Posted 19 Nov, 2020
Editor assigned
On 19 Nov, 2020
Reviewers invited
Invitations sent on 19 Nov, 2020
Reviewer #1 agreed
On 19 Nov, 2020
Submission checks complete
On 19 Nov, 2020
Editor invited
On 19 Nov, 2020
This version was not preprinted
No comments provided
Editorial decision: Moderate Revision
On 14 Nov, 2020
Review #1 received
Received 11 Nov, 2020
Review #2 received
Received 11 Nov, 2020
Reviewer #2 agreed
On 09 Nov, 2020
Reviewers invited
Invitations sent on 09 Nov, 2020
Reviewer #1 agreed
On 09 Nov, 2020
Editor assigned
On 08 Nov, 2020
Submission checks complete
On 08 Nov, 2020
Editor invited
On 08 Nov, 2020
No comments provided
Review #4 received
Received 01 Nov, 2020
Editorial decision: Major revision
On 01 Nov, 2020
Review #1 received
Received 23 Oct, 2020
Reviewer #4 agreed
On 22 Oct, 2020
Review #2 received
Received 20 Oct, 2020
Review #3 received
Received 19 Oct, 2020
Reviewer #3 agreed
On 17 Oct, 2020
Reviewers invited
Invitations sent on 16 Oct, 2020
Reviewer #1 agreed
On 16 Oct, 2020
Reviewer #2 agreed
On 16 Oct, 2020
Editor assigned
On 15 Oct, 2020
Submission checks complete
On 14 Oct, 2020
Editor invited
On 14 Oct, 2020
Version 1
Posted 18 Aug, 2020
No comments provided
Editorial decision: Major revision
On 04 Oct, 2020
Review #2 received
Received 07 Sep, 2020
Review #3 received
Received 07 Sep, 2020
Review #1 received
Received 03 Sep, 2020
Reviewer #3 agreed
On 24 Aug, 2020
Reviewer #1 agreed
On 20 Aug, 2020
Reviewer #2 agreed
On 20 Aug, 2020
Reviewers invited
Invitations sent on 19 Aug, 2020
Editor assigned
On 17 Aug, 2020
Submission checks complete
On 16 Aug, 2020
Editor invited
On 16 Aug, 2020
First submitted
On 14 Aug, 2020
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A new preprint design is coming!
We have improved readability, clarity, accessibility, and opportunities for engagement.
See the published version of this preprint at Lipids in Health and Disease.
This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research
Ki Young Son
Asan Medical Center, University of Ulsan College of Medicine
Corresponding Author
ORCiD: https://orcid.org/0000-0003-1262-100X
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Published
View the published article at Lipids in Health and Disease.
No community comments so far
Editorial decision: Accept
On 03 Dec, 2020
Editor assigned
On 22 Nov, 2020
Reviewers invited
Invitations sent on 22 Nov, 2020
Submission checks complete
On 22 Nov, 2020
Editor invited
On 22 Nov, 2020
Version (no preprint)
Posted 19 Nov, 2020
Editor assigned
On 19 Nov, 2020
Reviewers invited
Invitations sent on 19 Nov, 2020
Reviewer #1 agreed
On 19 Nov, 2020
Submission checks complete
On 19 Nov, 2020
Editor invited
On 19 Nov, 2020
This version was not preprinted
No comments provided
Editorial decision: Moderate Revision
On 14 Nov, 2020
Review #1 received
Received 11 Nov, 2020
Review #2 received
Received 11 Nov, 2020
Reviewer #2 agreed
On 09 Nov, 2020
Reviewers invited
Invitations sent on 09 Nov, 2020
Reviewer #1 agreed
On 09 Nov, 2020
Editor assigned
On 08 Nov, 2020
Submission checks complete
On 08 Nov, 2020
Editor invited
On 08 Nov, 2020
No comments provided
Review #4 received
Received 01 Nov, 2020
Editorial decision: Major revision
On 01 Nov, 2020
Review #1 received
Received 23 Oct, 2020
Reviewer #4 agreed
On 22 Oct, 2020
Review #2 received
Received 20 Oct, 2020
Review #3 received
Received 19 Oct, 2020
Reviewer #3 agreed
On 17 Oct, 2020
Reviewers invited
Invitations sent on 16 Oct, 2020
Reviewer #1 agreed
On 16 Oct, 2020
Reviewer #2 agreed
On 16 Oct, 2020
Editor assigned
On 15 Oct, 2020
Submission checks complete
On 14 Oct, 2020
Editor invited
On 14 Oct, 2020
Version 1
Posted 18 Aug, 2020
No comments provided
Editorial decision: Major revision
On 04 Oct, 2020
Review #2 received
Received 07 Sep, 2020
Review #3 received
Received 07 Sep, 2020
Review #1 received
Received 03 Sep, 2020
Reviewer #3 agreed
On 24 Aug, 2020
Reviewer #1 agreed
On 20 Aug, 2020
Reviewer #2 agreed
On 20 Aug, 2020
Reviewers invited
Invitations sent on 19 Aug, 2020
Editor assigned
On 17 Aug, 2020
Submission checks complete
On 16 Aug, 2020
Editor invited
On 16 Aug, 2020
First submitted
On 14 Aug, 2020
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
License:
This work is licensed under a CC BY 4.0 License. Read Full License
View the published article at Lipids in Health and Disease.
Background
Dyslipidemia is an independent health risk of cardiovascular disease (CVD), a leading cause of mortality in older adults. Despite their importance, there have been few reports on the association between lipoprotein cholesterol and future CVD and cardiovascular (CV) mortality among elderly Asians. This longitudinal study investigated the correlations in an elderly Korean population by using a large nationwide sample.
Methods
Among participants in the cohort database of the Korean National Health Insurance Service who completed the National Screening Program, a total of 62,604 adults aged 65 years or older (32,584 men and 30,020 women) were included. High-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C) values were categorized by quartiles. Cox proportional hazard models were used to assess the association between the quartiles of lipoprotein cholesterol and CV events or CV mortality.
Results
The mean follow-up period was 3.3 years. The incidence rates of ischemic heart disease and ischemic brain disease were 0.97 and 0.61 per 1,000 person-years, while the mortality rates from these diseases were 0.22 and 0.34 per 1,000 person-years, respectively. In a fully adjusted model, high HDL-C and LDL-C levels were not associated with the total CV events and CV mortality; however, high LDL-C levels were significantly associated with a lower incidence of ischemic brain disease. Furthermore, diabetic patients with high LDL-C were more likely to have higher CV mortality, whereas non-smokers with high LDL-C were less likely to be at risk of CV events.
Conclusions
Neither high LDL-C nor HDL-C was significantly associated with future CV mortality in older adults aged ≥65 years. Older adults with diabetes were significantly associated with a higher risk of CV mortality in high LDL-C levels.
Figure 1
Figure 2
Figure 3
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