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Research article
Lijun Shen
The Affiliated Eye Hospital of Wenzhou Medical University
Corresponding Author
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Objectives: To investigate the association between iOCT feature inmacular hole surgery and the restoration of the retina microstructure and visualoutcomes. M ethods: Fifty-three eyes of 53 patients with macular hole were recruited in this retrospective study. All eyes were assessed with intraoperative OCT after internal limiting membrane peeling. We divided the patients in to three groups:fovel flap group, hole-door group, and negative group，according to morphological changes on the edge of hole using iOCT after ILM peeling. We compared the anatomical and functional surgical outcomes between these groups. ResultsThe negative group had significantly poorer BCVA and restoration of the ELM than other two groups(P=0.002,0.012) at 6 months postoperatively. In the hole size ≤400um group，There were no statistical difference of ELM restoration and BCVA postoperatively between the groups. While in hole size > 400um group, The hole-door group and fovea flap group had significantly better final visual acuity and restoration of ELM than the negative group(P=0.013,P=0.005) Conclusion: This study describes a novel intraoperative sign using iOCT. This sign is a useful predictor of postoperative in restoration of the retina microstructure and visual outcomes of the macular hole，especially in large macular hole.
Keywords
Intraoperative OCT, ILM peeling, macular hole, retina microstructure, visual outcomes
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CURRENT STATUS: Published
View the published article at BMC Ophthalmology.
No community comments so far
Editorial decision: Minor revision
On 30 Mar, 2020
Review #1 received
Received 16 Mar, 2020
Review #2 received
Received 16 Mar, 2020
Reviewer #2 agreed
On 15 Mar, 2020
Reviewers invited
Invitations sent on 12 Mar, 2020
Reviewer #1 agreed
On 12 Mar, 2020
Editor assigned
On 04 Mar, 2020
Submission checks complete
On 03 Mar, 2020
Editor invited
On 03 Mar, 2020
Version 1
Posted 01 Oct, 2019
No comments provided
Editorial decision: Major revision
On 03 Feb, 2020
Review #3 received
Received 03 Feb, 2020
Review #2 received
Received 28 Jan, 2020
Reviewer #3 agreed
On 25 Jan, 2020
Reviewer #2 agreed
On 22 Jan, 2020
Review #1 received
Received 30 Dec, 2019
Reviewer #1 agreed
On 12 Dec, 2019
Reviewers invited
Invitations sent on 13 Nov, 2019
Editor assigned
On 24 Sep, 2019
Submission checks complete
On 23 Sep, 2019
Editor invited
On 23 Sep, 2019
Metrics
Comments: 0
PDF Downloads: ...
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Subject Areas
Ophthalmology
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A new preprint design is coming!
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See the published version of this preprint at BMC Ophthalmology.
This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research article
Lijun Shen
The Affiliated Eye Hospital of Wenzhou Medical University
Corresponding Author
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Published
View the published article at BMC Ophthalmology.
No community comments so far
Editorial decision: Minor revision
On 30 Mar, 2020
Review #1 received
Received 16 Mar, 2020
Review #2 received
Received 16 Mar, 2020
Reviewer #2 agreed
On 15 Mar, 2020
Reviewers invited
Invitations sent on 12 Mar, 2020
Reviewer #1 agreed
On 12 Mar, 2020
Editor assigned
On 04 Mar, 2020
Submission checks complete
On 03 Mar, 2020
Editor invited
On 03 Mar, 2020
Version 1
Posted 01 Oct, 2019
No comments provided
Editorial decision: Major revision
On 03 Feb, 2020
Review #3 received
Received 03 Feb, 2020
Review #2 received
Received 28 Jan, 2020
Reviewer #3 agreed
On 25 Jan, 2020
Reviewer #2 agreed
On 22 Jan, 2020
Review #1 received
Received 30 Dec, 2019
Reviewer #1 agreed
On 12 Dec, 2019
Reviewers invited
Invitations sent on 13 Nov, 2019
Editor assigned
On 24 Sep, 2019
Submission checks complete
On 23 Sep, 2019
Editor invited
On 23 Sep, 2019
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Ophthalmology
License:
This work is licensed under a CC BY 4.0 License. Read Full License
View the published article at BMC Ophthalmology.
Objectives: To investigate the association between iOCT feature inmacular hole surgery and the restoration of the retina microstructure and visualoutcomes. M ethods: Fifty-three eyes of 53 patients with macular hole were recruited in this retrospective study. All eyes were assessed with intraoperative OCT after internal limiting membrane peeling. We divided the patients in to three groups:fovel flap group, hole-door group, and negative group，according to morphological changes on the edge of hole using iOCT after ILM peeling. We compared the anatomical and functional surgical outcomes between these groups. ResultsThe negative group had significantly poorer BCVA and restoration of the ELM than other two groups(P=0.002,0.012) at 6 months postoperatively. In the hole size ≤400um group，There were no statistical difference of ELM restoration and BCVA postoperatively between the groups. While in hole size > 400um group, The hole-door group and fovea flap group had significantly better final visual acuity and restoration of ELM than the negative group(P=0.013,P=0.005) Conclusion: This study describes a novel intraoperative sign using iOCT. This sign is a useful predictor of postoperative in restoration of the retina microstructure and visual outcomes of the macular hole，especially in large macular hole.
Figure 1
Figure 2
Figure 3
This is a list of supplementary files associated with this preprint. Click to download.
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