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Research article
Lijun Shen
The Affiliated Eye Hospital of Wenzhou Medical University
Corresponding Author
License:
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Background: To investigate the association between iOCT feature in macular hole (MH) surgery and the restoration of the retina microstructure and visual outcomes.
Methods: This was a case series study including fifty-three eyes of 53 patients with macular hole were recruited. According to the morphological characteristics of the hole edge as imaged by iOCT after ILM peeling, all patients were divided into three groups: fovel flap group, hole-door group, and negative group. The restoration of the retina microstructure and postoperative visual outcomes of the MH surgery were compared between these groups.
Results: All of the eyes had MH closure after vitrectomy. The postoperative BCVA was significantly improved compared with the preoperative BCVA (P<0.001). Based on the features of the hole edge as reveal by iOCT, the negative group included 24 eyes, the fovea flap group included 14 eyes, and the hole-door group included 15 eyes. The hole-door group and foveal flap group had significantly better final visual acuity and postoperative restoration of the ELM than the negative group (P=0.002, P=0.012). For the group in which the MHD was ≤400 μm, there were no significant differences in ELM restoration, EZ restoration, or BCVA among the three groups (P=0.516 and P=0.179 respectively). For the MHD >400-μm group, the hole-door group and fovea flap group had significantly better final visual acuity and restoration of ELM than the negative group (P=0.013, P=0.005).
Conclusion: This study describes a novel intraoperative sign using iOCT. This sign can provide useful predictive information for postoperative restoration of the retinal microstructure and visual outcomes of MHs, especially large ones
Keywords
Intraoperative optical coherence tomography, internal limiting membrane peeling, macular hole, retina microstructure, visual outcomes
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CURRENT STATUS: Published
View the published article at BMC Ophthalmology.
Version 2
Posted 11 Mar, 2020
No community comments so far
Editorial decision: Minor revision
On 30 Mar, 2020
Review #1 received
Received 16 Mar, 2020
Review #2 received
Received 16 Mar, 2020
Reviewer #2 agreed
On 15 Mar, 2020
Reviewers invited
Invitations sent on 12 Mar, 2020
Reviewer #1 agreed
On 12 Mar, 2020
Editor assigned
On 04 Mar, 2020
Submission checks complete
On 03 Mar, 2020
Editor invited
On 03 Mar, 2020
No comments provided
Editorial decision: Major revision
On 03 Feb, 2020
Review #3 received
Received 03 Feb, 2020
Review #2 received
Received 28 Jan, 2020
Reviewer #3 agreed
On 25 Jan, 2020
Reviewer #2 agreed
On 22 Jan, 2020
Review #1 received
Received 30 Dec, 2019
Reviewer #1 agreed
On 12 Dec, 2019
Reviewers invited
Invitations sent on 13 Nov, 2019
Editor assigned
On 24 Sep, 2019
Submission checks complete
On 23 Sep, 2019
Editor invited
On 23 Sep, 2019
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Ophthalmology
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A new preprint design is coming!
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See the published version of this preprint at BMC Ophthalmology.
This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research article
Lijun Shen
The Affiliated Eye Hospital of Wenzhou Medical University
Corresponding Author
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Published
View the published article at BMC Ophthalmology.
Version 2
Posted 11 Mar, 2020
No community comments so far
Editorial decision: Minor revision
On 30 Mar, 2020
Review #1 received
Received 16 Mar, 2020
Review #2 received
Received 16 Mar, 2020
Reviewer #2 agreed
On 15 Mar, 2020
Reviewers invited
Invitations sent on 12 Mar, 2020
Reviewer #1 agreed
On 12 Mar, 2020
Editor assigned
On 04 Mar, 2020
Submission checks complete
On 03 Mar, 2020
Editor invited
On 03 Mar, 2020
No comments provided
Editorial decision: Major revision
On 03 Feb, 2020
Review #3 received
Received 03 Feb, 2020
Review #2 received
Received 28 Jan, 2020
Reviewer #3 agreed
On 25 Jan, 2020
Reviewer #2 agreed
On 22 Jan, 2020
Review #1 received
Received 30 Dec, 2019
Reviewer #1 agreed
On 12 Dec, 2019
Reviewers invited
Invitations sent on 13 Nov, 2019
Editor assigned
On 24 Sep, 2019
Submission checks complete
On 23 Sep, 2019
Editor invited
On 23 Sep, 2019
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Ophthalmology
License:
This work is licensed under a CC BY 4.0 License. Read Full License
View the published article at BMC Ophthalmology.
Background: To investigate the association between iOCT feature in macular hole (MH) surgery and the restoration of the retina microstructure and visual outcomes.
Methods: This was a case series study including fifty-three eyes of 53 patients with macular hole were recruited. According to the morphological characteristics of the hole edge as imaged by iOCT after ILM peeling, all patients were divided into three groups: fovel flap group, hole-door group, and negative group. The restoration of the retina microstructure and postoperative visual outcomes of the MH surgery were compared between these groups.
Results: All of the eyes had MH closure after vitrectomy. The postoperative BCVA was significantly improved compared with the preoperative BCVA (P<0.001). Based on the features of the hole edge as reveal by iOCT, the negative group included 24 eyes, the fovea flap group included 14 eyes, and the hole-door group included 15 eyes. The hole-door group and foveal flap group had significantly better final visual acuity and postoperative restoration of the ELM than the negative group (P=0.002, P=0.012). For the group in which the MHD was ≤400 μm, there were no significant differences in ELM restoration, EZ restoration, or BCVA among the three groups (P=0.516 and P=0.179 respectively). For the MHD >400-μm group, the hole-door group and fovea flap group had significantly better final visual acuity and restoration of ELM than the negative group (P=0.013, P=0.005).
Conclusion: This study describes a novel intraoperative sign using iOCT. This sign can provide useful predictive information for postoperative restoration of the retinal microstructure and visual outcomes of MHs, especially large ones
Figure 1
Figure 2
Figure 3
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