H2V: a database of human genes and proteins that respond to SARS-CoV-2, SARS-CoV, and MERS-CoV infection
Background
The ongoing global COVID-19 pandemic is caused by SARS-CoV-2, a novel coronavirus first discovered at the end of 2019. It has led to more than 50 million confirmed cases and more than 1 million deaths across 219 countries as of 11 November 2020, according to WHO statistics. SARS-CoV-2, SARS-CoV, and MERS-CoV are similar. They are highly pathogenic and threaten public health, impair the economy, and inflict long-term impacts on society. No drug or vaccine has been approved as a treatment for these viruses. Efforts to develop antiviral measures have been hampered by the insufficient understanding of how the human body responds to viral infections at the cellular and molecular levels.
Results
In this study, journal articles and transcriptomic and proteomic data surveying coronavirus infections were collected. Response genes and proteins were then identified by differential analyses comparing gene/protein levels between infected and control samples. Finally, the H2V database was created to contain the human genes and proteins that respond to SARS-CoV-2, SARS-CoV, and MERS-CoV infection.
Conclusions
H2V provides molecular information about the human response to infection. It can be a powerful tool to discover cellular pathways and processes relevant for viral pathogenesis to identify potential drug targets. It is expected to accelerate the process of antiviral agent development and to inform preparations for potential future coronavirus-related emergencies. The database is available at: http://www.zhounan.org/h2v.
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Posted 30 Dec, 2020
On 07 Dec, 2020
Received 26 Nov, 2020
Received 26 Nov, 2020
On 22 Nov, 2020
On 19 Nov, 2020
Invitations sent on 19 Nov, 2020
On 19 Nov, 2020
On 18 Nov, 2020
On 18 Nov, 2020
On 18 Nov, 2020
Received 17 Sep, 2020
On 17 Sep, 2020
On 31 Aug, 2020
On 26 Aug, 2020
Invitations sent on 24 Aug, 2020
On 24 Aug, 2020
On 24 Aug, 2020
On 24 Aug, 2020
Received 24 Aug, 2020
Received 24 Aug, 2020
On 06 Aug, 2020
On 05 Aug, 2020
On 05 Aug, 2020
On 05 Aug, 2020
H2V: a database of human genes and proteins that respond to SARS-CoV-2, SARS-CoV, and MERS-CoV infection
Posted 30 Dec, 2020
On 07 Dec, 2020
Received 26 Nov, 2020
Received 26 Nov, 2020
On 22 Nov, 2020
On 19 Nov, 2020
Invitations sent on 19 Nov, 2020
On 19 Nov, 2020
On 18 Nov, 2020
On 18 Nov, 2020
On 18 Nov, 2020
Received 17 Sep, 2020
On 17 Sep, 2020
On 31 Aug, 2020
On 26 Aug, 2020
Invitations sent on 24 Aug, 2020
On 24 Aug, 2020
On 24 Aug, 2020
On 24 Aug, 2020
Received 24 Aug, 2020
Received 24 Aug, 2020
On 06 Aug, 2020
On 05 Aug, 2020
On 05 Aug, 2020
On 05 Aug, 2020
Background
The ongoing global COVID-19 pandemic is caused by SARS-CoV-2, a novel coronavirus first discovered at the end of 2019. It has led to more than 50 million confirmed cases and more than 1 million deaths across 219 countries as of 11 November 2020, according to WHO statistics. SARS-CoV-2, SARS-CoV, and MERS-CoV are similar. They are highly pathogenic and threaten public health, impair the economy, and inflict long-term impacts on society. No drug or vaccine has been approved as a treatment for these viruses. Efforts to develop antiviral measures have been hampered by the insufficient understanding of how the human body responds to viral infections at the cellular and molecular levels.
Results
In this study, journal articles and transcriptomic and proteomic data surveying coronavirus infections were collected. Response genes and proteins were then identified by differential analyses comparing gene/protein levels between infected and control samples. Finally, the H2V database was created to contain the human genes and proteins that respond to SARS-CoV-2, SARS-CoV, and MERS-CoV infection.
Conclusions
H2V provides molecular information about the human response to infection. It can be a powerful tool to discover cellular pathways and processes relevant for viral pathogenesis to identify potential drug targets. It is expected to accelerate the process of antiviral agent development and to inform preparations for potential future coronavirus-related emergencies. The database is available at: http://www.zhounan.org/h2v.
Figure 1
Figure 2
Figure 3
Figure 4