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Research article
Mingyao Ke
Xiamen Medical College Affiliated Second Hospital
Corresponding Author
ORCiD: https://orcid.org/0000-0003-4715-3509
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Objective: Bronchopleural fistula is a rare but life-threatening event with limited therapeutic options. Aim of our study is to investigate the efficacy and safety of the modified silicone stent in patients with bronchopleural fistula.
Method: Between March 2016 and April 2020, we retrospectively collected 17 patients with bronchopleural fistula and who underwent bronchoscopic placement of the modified silicone sten. The Y-shaped stent was tailored and sutured manually. The initial success, clinical success, the cured rate and complications were recorded.
Results: Placement of the modified silicone stent was successful in 16 patients on first attempt (initial success rate was 94.1%). The median follow-up time was 107(rang, 5-431) days. The amelioration of respiratory symptoms was reported in all patients. There were 14 patients with empyema, the daily drainage was significantly decreased in 11 patients over time, and the purulent fluid completely disappeared in six patients. The clinical success rate was 76.5%. There were seven stents was removed during follow-up, four (26.7%) removed for cured fistula, two for the severe proliferation of granulation tissue and one for the dislocation of stent. No severe adverse events of stent migration and suture dehiscence happened. There were three cases were lost to follow-up and seven patients succumbed. The cause of death included progression of primary malignance, the uncontrolled infection, myocardial infarction and left heart failure.
Conclusion: The modified silicone stent may be an effective and safe option for bronchopleural fistula patients in whom the conventional therapy is inappropriate and contraindicated.
Keywords
Modified silicone stent, bronchopleural fistula, Rigid bronchoscopy
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CURRENT STATUS: Published
View the published article at BMC Pulmonary Medicine.
No community comments so far
Submission checks complete
On 10 Dec, 2020
Editorial decision: Accept
On 09 Dec, 2020
Version (no preprint)
Posted 05 Dec, 2020
Submission checks complete
On 05 Dec, 2020
Editorial decision: Minor revision
On 03 Dec, 2020
This version was not preprinted
No comments provided
Editorial decision: Minor revision
On 29 Nov, 2020
Review #3 received
Received 28 Nov, 2020
Reviewer #2 agreed
On 23 Nov, 2020
Reviewer #3 agreed
On 23 Nov, 2020
Reviewer #1 agreed
On 23 Nov, 2020
Review #1 received
Received 23 Nov, 2020
Review #2 received
Received 23 Nov, 2020
Reviewers invited
Invitations sent on 22 Nov, 2020
Editor assigned
On 15 Nov, 2020
Submission checks complete
On 15 Nov, 2020
Editor invited
On 15 Nov, 2020
Version 1
Posted 28 Aug, 2020
No comments provided
Editorial decision: Major revision
On 14 Oct, 2020
Review #1 received
Received 13 Oct, 2020
Review #3 received
Received 11 Oct, 2020
Review #4 received
Received 01 Oct, 2020
Review #2 received
Received 28 Sep, 2020
Reviewer #4 agreed
On 23 Sep, 2020
Reviewer #5 agreed
On 23 Sep, 2020
Reviewer #2 agreed
On 21 Sep, 2020
Reviewer #3 agreed
On 21 Sep, 2020
Reviewer #1 agreed
On 20 Sep, 2020
Reviewers invited
Invitations sent on 29 Aug, 2020
Editor assigned
On 18 Aug, 2020
First submitted
On 17 Aug, 2020
Submission checks complete
On 17 Aug, 2020
Editor invited
On 17 Aug, 2020
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Subject Areas
Pulmonology
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A new preprint design is coming!
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See the published version of this preprint at BMC Pulmonary Medicine.
This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research article
Mingyao Ke
Xiamen Medical College Affiliated Second Hospital
Corresponding Author
ORCiD: https://orcid.org/0000-0003-4715-3509
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Published
View the published article at BMC Pulmonary Medicine.
No community comments so far
Submission checks complete
On 10 Dec, 2020
Editorial decision: Accept
On 09 Dec, 2020
Version (no preprint)
Posted 05 Dec, 2020
Submission checks complete
On 05 Dec, 2020
Editorial decision: Minor revision
On 03 Dec, 2020
This version was not preprinted
No comments provided
Editorial decision: Minor revision
On 29 Nov, 2020
Review #3 received
Received 28 Nov, 2020
Reviewer #2 agreed
On 23 Nov, 2020
Reviewer #3 agreed
On 23 Nov, 2020
Reviewer #1 agreed
On 23 Nov, 2020
Review #1 received
Received 23 Nov, 2020
Review #2 received
Received 23 Nov, 2020
Reviewers invited
Invitations sent on 22 Nov, 2020
Editor assigned
On 15 Nov, 2020
Submission checks complete
On 15 Nov, 2020
Editor invited
On 15 Nov, 2020
Version 1
Posted 28 Aug, 2020
No comments provided
Editorial decision: Major revision
On 14 Oct, 2020
Review #1 received
Received 13 Oct, 2020
Review #3 received
Received 11 Oct, 2020
Review #4 received
Received 01 Oct, 2020
Review #2 received
Received 28 Sep, 2020
Reviewer #4 agreed
On 23 Sep, 2020
Reviewer #5 agreed
On 23 Sep, 2020
Reviewer #2 agreed
On 21 Sep, 2020
Reviewer #3 agreed
On 21 Sep, 2020
Reviewer #1 agreed
On 20 Sep, 2020
Reviewers invited
Invitations sent on 29 Aug, 2020
Editor assigned
On 18 Aug, 2020
First submitted
On 17 Aug, 2020
Submission checks complete
On 17 Aug, 2020
Editor invited
On 17 Aug, 2020
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Pulmonology
License:
This work is licensed under a CC BY 4.0 License. Read Full License
View the published article at BMC Pulmonary Medicine.
Objective: Bronchopleural fistula is a rare but life-threatening event with limited therapeutic options. Aim of our study is to investigate the efficacy and safety of the modified silicone stent in patients with bronchopleural fistula.
Method: Between March 2016 and April 2020, we retrospectively collected 17 patients with bronchopleural fistula and who underwent bronchoscopic placement of the modified silicone sten. The Y-shaped stent was tailored and sutured manually. The initial success, clinical success, the cured rate and complications were recorded.
Results: Placement of the modified silicone stent was successful in 16 patients on first attempt (initial success rate was 94.1%). The median follow-up time was 107(rang, 5-431) days. The amelioration of respiratory symptoms was reported in all patients. There were 14 patients with empyema, the daily drainage was significantly decreased in 11 patients over time, and the purulent fluid completely disappeared in six patients. The clinical success rate was 76.5%. There were seven stents was removed during follow-up, four (26.7%) removed for cured fistula, two for the severe proliferation of granulation tissue and one for the dislocation of stent. No severe adverse events of stent migration and suture dehiscence happened. There were three cases were lost to follow-up and seven patients succumbed. The cause of death included progression of primary malignance, the uncontrolled infection, myocardial infarction and left heart failure.
Conclusion: The modified silicone stent may be an effective and safe option for bronchopleural fistula patients in whom the conventional therapy is inappropriate and contraindicated.
Figure 1
Figure 2
Figure 3
Figure 4
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