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Research article
Mingyao Ke
Xiamen Medical College Affiliated Second Hospital
Corresponding Author
ORCiD: https://orcid.org/0000-0003-4715-3509
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background: Bronchopleural fistula is a rare but life-threatening event with limited therapeutic options. We aimed to investigate the efficacy and safety of the modified silicone stent in patients with post-surgical bronchopleural fistula.
Methods: Between March 2016 and April 2020, we retrospectively reviewed the records of 17 patients with bronchopleural fistula and who underwent bronchoscopic placement of the Y-shaped silicone stent. The rate of initial success, clinical success and clinical cure, and complications were analyzed.
Results: Stent placement was successful in 16 patients in the first attempt (initial success rate: 94.1%). The median follow-up time was 107 (range, 5-431) days. All patients achieved amelioration of respiratory symptoms. The clinical success rate was 76.5%. Of the 14 patients with empyema, the daily drainage was progressively decreased in 11 patients, and empyema completely disappeared in six patients. Seven stents were removed during follow-up: four (26.7%) for the cure of fistula, two for severe proliferation of granulomatous tissue and one for stent dislocation. No severe adverse events (i.e. massive hemoptysis, suture dehiscence) took place. Seven patients died (due to progression of malignancy, uncontrolled infection, myocardial infarction and left heart failure).
Conclusions: The modified silicone stent may be an effective and safe option for patients with post-surgical bronchopleural fistula patients in whom conventional therapy is contraindicated.
Keywords
Modified silicone stent, bronchopleural fistula, Rigid bronchoscopy
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CURRENT STATUS: Published
View the published article at BMC Pulmonary Medicine.
Version 3
Posted 21 Dec, 2020
No community comments so far
Submission checks complete
On 10 Dec, 2020
Editorial decision: Accept
On 09 Dec, 2020
Version (no preprint)
Posted 05 Dec, 2020
Submission checks complete
On 05 Dec, 2020
Editorial decision: Minor revision
On 03 Dec, 2020
This version was not preprinted
No comments provided
Editorial decision: Minor revision
On 29 Nov, 2020
Review #3 received
Received 28 Nov, 2020
Reviewer #2 agreed
On 23 Nov, 2020
Reviewer #3 agreed
On 23 Nov, 2020
Reviewer #1 agreed
On 23 Nov, 2020
Review #1 received
Received 23 Nov, 2020
Review #2 received
Received 23 Nov, 2020
Reviewers invited
Invitations sent on 22 Nov, 2020
Editor assigned
On 15 Nov, 2020
Submission checks complete
On 15 Nov, 2020
Editor invited
On 15 Nov, 2020
No comments provided
Editorial decision: Major revision
On 14 Oct, 2020
Review #1 received
Received 13 Oct, 2020
Review #3 received
Received 11 Oct, 2020
Review #4 received
Received 01 Oct, 2020
Review #2 received
Received 28 Sep, 2020
Reviewer #4 agreed
On 23 Sep, 2020
Reviewer #5 agreed
On 23 Sep, 2020
Reviewer #2 agreed
On 21 Sep, 2020
Reviewer #3 agreed
On 21 Sep, 2020
Reviewer #1 agreed
On 20 Sep, 2020
Reviewers invited
Invitations sent on 29 Aug, 2020
Editor assigned
On 18 Aug, 2020
First submitted
On 17 Aug, 2020
Submission checks complete
On 17 Aug, 2020
Editor invited
On 17 Aug, 2020
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Subject Areas
Pulmonology
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A new preprint design is coming!
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See the published version of this preprint at BMC Pulmonary Medicine.
This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research article
Mingyao Ke
Xiamen Medical College Affiliated Second Hospital
Corresponding Author
ORCiD: https://orcid.org/0000-0003-4715-3509
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Published
View the published article at BMC Pulmonary Medicine.
Version 3
Posted 21 Dec, 2020
No community comments so far
Submission checks complete
On 10 Dec, 2020
Editorial decision: Accept
On 09 Dec, 2020
Version (no preprint)
Posted 05 Dec, 2020
Submission checks complete
On 05 Dec, 2020
Editorial decision: Minor revision
On 03 Dec, 2020
This version was not preprinted
No comments provided
Editorial decision: Minor revision
On 29 Nov, 2020
Review #3 received
Received 28 Nov, 2020
Reviewer #2 agreed
On 23 Nov, 2020
Reviewer #3 agreed
On 23 Nov, 2020
Reviewer #1 agreed
On 23 Nov, 2020
Review #1 received
Received 23 Nov, 2020
Review #2 received
Received 23 Nov, 2020
Reviewers invited
Invitations sent on 22 Nov, 2020
Editor assigned
On 15 Nov, 2020
Submission checks complete
On 15 Nov, 2020
Editor invited
On 15 Nov, 2020
No comments provided
Editorial decision: Major revision
On 14 Oct, 2020
Review #1 received
Received 13 Oct, 2020
Review #3 received
Received 11 Oct, 2020
Review #4 received
Received 01 Oct, 2020
Review #2 received
Received 28 Sep, 2020
Reviewer #4 agreed
On 23 Sep, 2020
Reviewer #5 agreed
On 23 Sep, 2020
Reviewer #2 agreed
On 21 Sep, 2020
Reviewer #3 agreed
On 21 Sep, 2020
Reviewer #1 agreed
On 20 Sep, 2020
Reviewers invited
Invitations sent on 29 Aug, 2020
Editor assigned
On 18 Aug, 2020
First submitted
On 17 Aug, 2020
Submission checks complete
On 17 Aug, 2020
Editor invited
On 17 Aug, 2020
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Pulmonology
License:
This work is licensed under a CC BY 4.0 License. Read Full License
View the published article at BMC Pulmonary Medicine.
Background: Bronchopleural fistula is a rare but life-threatening event with limited therapeutic options. We aimed to investigate the efficacy and safety of the modified silicone stent in patients with post-surgical bronchopleural fistula.
Methods: Between March 2016 and April 2020, we retrospectively reviewed the records of 17 patients with bronchopleural fistula and who underwent bronchoscopic placement of the Y-shaped silicone stent. The rate of initial success, clinical success and clinical cure, and complications were analyzed.
Results: Stent placement was successful in 16 patients in the first attempt (initial success rate: 94.1%). The median follow-up time was 107 (range, 5-431) days. All patients achieved amelioration of respiratory symptoms. The clinical success rate was 76.5%. Of the 14 patients with empyema, the daily drainage was progressively decreased in 11 patients, and empyema completely disappeared in six patients. Seven stents were removed during follow-up: four (26.7%) for the cure of fistula, two for severe proliferation of granulomatous tissue and one for stent dislocation. No severe adverse events (i.e. massive hemoptysis, suture dehiscence) took place. Seven patients died (due to progression of malignancy, uncontrolled infection, myocardial infarction and left heart failure).
Conclusions: The modified silicone stent may be an effective and safe option for patients with post-surgical bronchopleural fistula patients in whom conventional therapy is contraindicated.
Figure 1
Figure 2
Figure 3
Figure 4
Figure 5
This is a list of supplementary files associated with this preprint. Click to download.
- Supplementarytable.docx
- supplementaryfile.docx
Online Methods
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