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Research article
Ying Chen
The Affiliated Hospital of Qingdao University
Corresponding Author
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This work is licensed under a CC BY 4.0 License. Read Full License
Background: Gestational diabetes mellitus (GDM) is a pregnancy-specific carbohydrate intolerance Which can cause a large number of perinatal and postpartum complications. The members of Transforming growth factor-β (TGF-β) superfamily play key roles in the homeostasis of pancreatic β-cell and may involve in the development of GDM. This study aimed to explore the association between the polymorphisms of TGF-β1 , TGF-β3 and the risk to GDM in Chinese women.
Methods: This study included 919 GDM patients(464 with preeclampsia and 455 without preeclampsia) and 1177 healthy pregnant women. TaqMan allelic discrimination real-Time PCR was used to genotyped the TGF-β1 (rs4803455) and TGF-β3 (rs2284792 and rs3917201) were by, The Hardy-Weinberg equilibrium (HWE) was evaluated by chi-square test.
Results: An increased frequency of TGF-β3 rs2284792 AA and AG genotype carriers was founded in GDM patients (AA vs. AG+GG: χ²=6.314, P=0.012, OR=1.270, 95%CI 1.054-1.530; AG vs. GG+AA: χ²=8.545, P=0.003, OR=0.773, 95%CI 0.650-0.919). But there were no significant differences in the distribution of TGF-β1 rs4803455 and TGF-β3 rs3917201 between GDM and healthy women. And no significant differences were found in allele and genotype frequencies among GDM patients with preeclampsia (PE).
Conclusions: The AA and AG genotype of TGF-β3 rs2284792 polymorphism may be significantly associated with increased risk of GDM in Chinese population.
Keywords
polymorphism, GDM, PE, TGF-β1, TGF-β3
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CURRENT STATUS: Published
View the published article at BMC Pregnancy and Childbirth.
No community comments so far
Submission checks complete
On 28 Nov, 2020
Editorial decision: Accept
On 24 Nov, 2020
No comments provided
Editorial decision: Minor revision
On 20 Nov, 2020
Reviewer #2 agreed
On 18 Nov, 2020
Review #2 received
Received 18 Nov, 2020
Reviewers invited
Invitations sent on 18 Nov, 2020
Reviewer #1 agreed
On 18 Nov, 2020
Review #1 received
Received 18 Nov, 2020
Editor assigned
On 14 Nov, 2020
Submission checks complete
On 14 Nov, 2020
Editor invited
On 14 Nov, 2020
Version 1
Posted 03 Sep, 2020
No comments provided
Editorial decision: Minor revision
On 28 Oct, 2020
Review #2 received
Received 25 Oct, 2020
Reviewer #2 agreed
On 11 Oct, 2020
Review #1 received
Received 30 Sep, 2020
Reviewer #1 agreed
On 14 Sep, 2020
Reviewers invited
Invitations sent on 03 Sep, 2020
Editor assigned
On 20 Aug, 2020
Submission checks complete
On 19 Aug, 2020
Editor invited
On 19 Aug, 2020
First submitted
On 18 Aug, 2020
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Maternal & Fetal Medicine
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A new preprint design is coming!
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See the published version of this preprint at BMC Pregnancy and Childbirth.
This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research article
Ying Chen
The Affiliated Hospital of Qingdao University
Corresponding Author
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Published
View the published article at BMC Pregnancy and Childbirth.
No community comments so far
Submission checks complete
On 28 Nov, 2020
Editorial decision: Accept
On 24 Nov, 2020
No comments provided
Editorial decision: Minor revision
On 20 Nov, 2020
Reviewer #2 agreed
On 18 Nov, 2020
Review #2 received
Received 18 Nov, 2020
Reviewers invited
Invitations sent on 18 Nov, 2020
Reviewer #1 agreed
On 18 Nov, 2020
Review #1 received
Received 18 Nov, 2020
Editor assigned
On 14 Nov, 2020
Submission checks complete
On 14 Nov, 2020
Editor invited
On 14 Nov, 2020
Version 1
Posted 03 Sep, 2020
No comments provided
Editorial decision: Minor revision
On 28 Oct, 2020
Review #2 received
Received 25 Oct, 2020
Reviewer #2 agreed
On 11 Oct, 2020
Review #1 received
Received 30 Sep, 2020
Reviewer #1 agreed
On 14 Sep, 2020
Reviewers invited
Invitations sent on 03 Sep, 2020
Editor assigned
On 20 Aug, 2020
Submission checks complete
On 19 Aug, 2020
Editor invited
On 19 Aug, 2020
First submitted
On 18 Aug, 2020
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Maternal & Fetal Medicine
License:
This work is licensed under a CC BY 4.0 License. Read Full License
View the published article at BMC Pregnancy and Childbirth.
Background: Gestational diabetes mellitus (GDM) is a pregnancy-specific carbohydrate intolerance Which can cause a large number of perinatal and postpartum complications. The members of Transforming growth factor-β (TGF-β) superfamily play key roles in the homeostasis of pancreatic β-cell and may involve in the development of GDM. This study aimed to explore the association between the polymorphisms of TGF-β1 , TGF-β3 and the risk to GDM in Chinese women.
Methods: This study included 919 GDM patients(464 with preeclampsia and 455 without preeclampsia) and 1177 healthy pregnant women. TaqMan allelic discrimination real-Time PCR was used to genotyped the TGF-β1 (rs4803455) and TGF-β3 (rs2284792 and rs3917201) were by, The Hardy-Weinberg equilibrium (HWE) was evaluated by chi-square test.
Results: An increased frequency of TGF-β3 rs2284792 AA and AG genotype carriers was founded in GDM patients (AA vs. AG+GG: χ²=6.314, P=0.012, OR=1.270, 95%CI 1.054-1.530; AG vs. GG+AA: χ²=8.545, P=0.003, OR=0.773, 95%CI 0.650-0.919). But there were no significant differences in the distribution of TGF-β1 rs4803455 and TGF-β3 rs3917201 between GDM and healthy women. And no significant differences were found in allele and genotype frequencies among GDM patients with preeclampsia (PE).
Conclusions: The AA and AG genotype of TGF-β3 rs2284792 polymorphism may be significantly associated with increased risk of GDM in Chinese population.
The full text of this article is available to read as a PDF.
This is a list of supplementary files associated with this preprint. Click to download.
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