Catastrophic Health Expenditures and Its Inequality in Rural Poor Households in China

DOI: https://doi.org/10.21203/rs.3.rs-627647/v1

Abstract

Background: Catastrophic health expenditure (CHE) is an important indicator to measure health equity. Reducing risk of CHE and breaking vicious cycle between poverty and poor health are original intentions of medical security system design in various countries. This paper fulfills a research gap on CHE and its inequality in Chinese rural poor households.

Methods: Based on 2018 China Health and Retirement Longitudinal Study Data (CHARLS), Logit and Tobit regression models were used to analyze CHE incidence and intensity among rural poor households, and its socioeconomic inequality.

Results: The results showed that CHE incidence of rural poor households was 28.20%, and the average intensity was 0.076. For rural poor households, CHE incidence and intensity were higher than those in non-poor households at each given threshold from 20% to 60%. Socioeconomic factors including household size, chronic disease status, disability status, health service utilization, whether to have older adults ≥ 65 significantly associated with household CHE.

Conclusions: Although China's social health insurance has almost achieved universal coverage, CHE incidence of rural poor households still remains high. A more refined health insurance policy with expanding current benefits packages, increasing reimbursement level is essential for protecting rural poor households from incurring CHE. Policy makers should also establish a new medical assistance system based on healthcare expenditure, which can effectively relieve medical economy burden of rural impoverished households.

Background

Poverty is a global issue that requires hard work of all governments. The relationship between poverty and health has been well documented [1, 2]. To break vicious cycle between poverty and poor health, healthcare system becomes the fundamental part of protecting households from disease-associated financial catastrophe [3]. However, needed healthcare remains unavailable to millions of people owing to economic status, especially in poor and vulnerable groups [4, 5]. According to statistics from WHO, nearly 100 million people were pushed into poverty due to high out-of-pocket payments (OOP) [6].

OOP refer to the payments paid by individuals directly to health care providers [7]. Empirical evidence indicated that OOP was the most inefficient and inequitable means of healthcare financing, and prevented patients from seeking medical services [3]. CHE occurs when OOP consumed a huge part of a household’s available income, thus forcing the household into risk of impoverishment [8, 9]. Even modest healthcare bills could compel households into facing CHE, when health financing mechanisms are unavailable or deficient. The possibility of CHE leading to household impoverishment raises equity concerns [10].

Different approaches were used to measure CHE: OOP account for ≥ 10% of total household expenditures [1113], and OOP account for ≥ 40% of non-food household expenditures, which is proposed by WHO [14, 15]. Previous studies suggested that a wide range of household characteristics associated with CHE. Logically, income is the most significant factor contributing to CHE inequality [16, 17]. Availability of health insurance can help reduce CHE incidence [11, 18]. On the contrary, households with older adults ≥ 65, children ≤ 5, chronically ill members, disabled members [19], and those who use inpatient healthcare services are facing higher risk of CHE [20]. Compared to households with more members, households with fewer people are more likely to occur CHE [21]. There are also some other factors associating with CHE: gender, education level of household head, and healthcare service utilization [22].

On a global scale, the proportion of OOP in the world's population exceeding 10% of total household expenditure increased from 9.4% in 2000 to 12.7% in 2015 [23]. Previous studies indicated that CHE incidence (non-food threshold of 40%) in France in 2011, Sweden in 2012, Germany in 2013 and Britain in 2014 was only1.9%, 1.8%, 2.4% and 1.4%, respectively, which were much lower than average level of 3% in OECD countries [24]. But for developing and underdeveloped countries, the situation is not so optimistic owing to lack of risk-share mechanism. In 2008, 11.8% of Iran's population incurred CHE and was compelled into poverty [25]. China is no exception, previous study showed CHE incidence in 2015 was 16.5%, and the households that actually incurred CHE spent 64% of their non-food consumption expenditure on medical expenses [26].

Therefore, to protect rural residents from large medical expenses, China has established New Rural Cooperative Medical Insurance (NRCMI) in 2003.In 2016, to further improve medical insurance level for rural residents, Chinese government decided to set up Urban and Rural Residents' Medical Insurance (URRMI) combined by both NRCMI and Urban Resident Basic Medical Insurance (URBMI).Despite realization of full coverage, the medical economy burden of Chinese residents was still high with OOP accounting for 28.61% in 2018[26].There was evidence showing that households insured by NRCMI almost had the same levels of CHE as those without any type of insurance[2729].Moreover, several Chinese studies also reported that compare to urban households, rural households were still facing higher CHE risk, which associated with the fairness of healthcare services [3032].

Numerous studies have conducted CHE studies on a specific country rather than vulnerable groups in the country. Owing to economic status, these vulnerable groups are still prevented from seeking needed and timely healthcare, and medical insurance systems haven’t played an effective role in protecting them from occurring CHE [33]. However, few studies have examined incidence and determinant factors of CHE among rural impoverished households in China. As China has gradually realized the universal coverage of basic medical insurance system over the past three decades, relieving economy burden of rural poor residents’ healthcare services and reducing inequality in medical insurance should gradually become the focus of new reform. Therefore, based on 2018 CHARLS data, this study aimed to analyze CHE incidence and intensity among rural poor households, and its socioeconomic inequality. Furthermore, our findings may contribute to improvement and adjustment of URRMI, thereby further relieve economy burden of healthcare and promote equity of healthcare system and services.

Materials And Methods

Data Source

Data were obtained from 2018 CHARLS, which is a national household survey collected by Peking University through multi-stage sampling method. The survey aims to collect national data of households and individuals ≥ 45 in 28 provinces in China. The CHARLS questionnaire was designed according to international standards, including Health and Retirement Study (HRS) and etc. Therefore, the CHARLS survey data is internationally comparable and more valuable for assessing China’s CHE incidence using WHO indicators. In 2018, the total number of households sampled was 11635, and the number of rural households was 8252. Based on the needs of CHE measurement, 591 households were excluded with missing variables, 7661 rural households were eventually included. According to China's poverty standard in 2018, which is 4833.4 CNY (1USD = 6.8792CNY, 2018) of rural residents’ annual per capita net income, we obtain 3408 rural poor households and 4253 non-poor households.

Indicators

For the measurement of CHE incidence, we adopted the one proposed by WHO: when household’s OOP is ≥ 40% of household’s non-food household expenditure CTP (Capacity to pay), it is considered as catastrophic [34]. There are also some studies adopting another measurement that is, if OOP is ≥ 10% of total household expenditure [35]. In this study, we use WHO indicator due to the reason that deducting food expenditure can partly avoid measurement aviation.

The CHARLS questionnaire contents included general information on socio-economic and demographic households’ characteristics, and healthcare utilization status. Our independent variables on each household comprised household size, per capita income of household, household with children ≤ 5 years old, household with older adults ≥ 65 years old, household including disabled members, household members with chronic disease, household members having sought outpatient care service during the past month, household members having sought inpatient care service during the past year, educational level of household head, and per capita security level of URRMI.

Based on 2018 CHARLS data, the variables of household size, per capita income and educational level of household head were set as continuous variables. Among which, we calculated per capita income of household by dividing the total household income by the number of household’s members and taking the logarithm. Furthermore, according to the questionnaire and answer setting, household head’s education level was divided into 0–5 points as “illiterate = 0;did not finish primary school/home school = 1; elementary school = 2; middle school = 3; high school/ vocational school = 4; two-/three-year college/associate/bachelor’s degree = 5”.Other variables including household with children ≤ 5, household with older adults ≥ 65,household with disabled member, household with chronically-ill member, household including member having sought outpatient care service during the past month and household including member having sought inpatient care service during the past year were set as dummy variables "yes = 1, no = 0". With regards to the variables of system and region, we calculated the proportion of per capita financing level of URRMI in per capita health care expenditure in each region (province, autonomous region, municipality directly under China’s central government) to get the per capita security level of URRMI.

Statistical Methods

Stata 15.0 was used for descriptive analysis and measurement of CHE. The confidence level was set as p < 0.05. To observe CHE incidence and intensity at each threshold based on 20%, 30%, 40%, 50%, and 60% of CTP. Moreover, for the analysis of influencing factors of CHE, we used the 40% threshold proposed by WHO.

Results

Descriptive Statistics

Descriptive statistics of characteristics of all rural households is concluded in Table 1. Among all rural households, the average household size was 2.762 and the mean household size of rural poor households (2.734) was a bit lower than that of non-poor ones (2.784). The proportion of children ≤ 5 and older adults ≥ 65 in rural poor and non-poor households were 10.04%, 7.81% and 58.66%, 35.13% respectively. Moreover, 23.21% of rural poor households reported having members who were disabled, and 60.80% of households with chronic diseases which were slightly higher than non-poor households(60.71%). With regards to healthcare utilization, 17.49% of rural poor households reported to have members having sought outpatient care service during the past month in comparison with non-poor households (15.89%). Almost one in five rural poor households (19.31%) reported to have members having sought inpatient care service during the past year.

As for education background, most rural poor household heads reported having a poor education concentrated in illiteracy, primary school, and elementary school (1.197), which was a bit lower in comparison with household heads registered as non-poor households (1.714). With regards to control variable, per capita security level of URRMI was 0.403 in rural poor households, which was also a little lower than that in non-poor households (0.406).

Table 1

Characteristics of Rural Poor and Non-poor Households

Characteristics

Total

Rural poor

Rural non-poor

p-value

(N = 7661)

(N = 3408)

(N = 4253)

Household variables

     

Household size

2.762

2.734

2.784

0.150

Household with children ≤ 5 years old

Yes

8.80%(674)

10.04%(342)

7.81%(332)

0.001

No

91.20%(6987)

89.96%(3066)

92.19%(3921)

Household with older adults ≥ 65 years old

Yes

45.59%(3493)

58.66%(1999)

35.13%(1494)

0.000

No

54.41%(4168)

41.34%(1409)

64.87%(2759)

Household including disabled member

Yes

20.52%(1572)

23.21%(791)

18.36%(781)

0.000

No

79.48%(6089)

76.79%(2617)

81.64%(3472)

Household including member with chronic disease

Yes

60.75%(4654)

60.80%(2072)

60.71%(2582)

0.937

No

39.25%(3007)

39.20%(1336)

39.29%(1671)

Per capita income

8.404

6.977

9.548

0.000

Household member having sought outpatient service during the past month

Yes

16.60%(1272)

17.49%(596)

15.89%(676)

0.062

No

83.40%(6389)

82.51%(2812)

84.11%(3577)

Household member having sought inpatient service during the past year

Yes

16.67%(1277)

19.31%(548)

14.55%(619)

0.000

No

83.33%(6384)

80.69%(2750)

85.45%(3634)

Educational level of household head

1.484

1.197

1.714

0.000

Region variable

Per capita security level of URRMI

0.405

0.403

0.406

0.112


CHE Incidence and Intensity in Rural Poor and Non-poor Households

In Table 2, with threshold level increasing from 20–60%, CHE incidence and intensity in both rural poor and non-poor households dropped remarkably. More importantly, at any given threshold, rural poor households were facing significantly higher headcount and overshoot than non-poor ones. At the lowest threshold of 20%, rural poor households experienced the highest CHE incidence (45.89%) and intensity (0.1486). Even at the highest 60% threshold, almost one in six (16.52%) rural poor households had gone through CHE experience. By applying WHO standard of 40% threshold, CHE incidence and intensity among rural poor households were 28.20% and 0.0756 respectively. Of all households sampled, rural non-poor households demonstrated the greatest headcount (8.72%) and overshoot (0.0014) at the highest 60% threshold.

Table 2

Incidence and Intensity of CHE

 

Catastrophic threshold

20%

30%

40%

50%

60%

Total sample

Headcount

38.58%

29.09%

22.13%

16.56%

12.19%

Mean positive overshoot

0.1145

0.0810

0.0554

0.0363

0.0219

Poverty sample

Headcount

45.89%

36.30%

28.20%

21.80%

16.52%

Mean positive overshoot

0.1486

0.1078

0.0756

0.0508

0.0316

Non-poverty sample

Headcount

32.73%

23.32%

17.28%

12.37%

8.72%

Mean positive overshoot

0.0874

0.0595

0.0393

0.0246

0.0014

Difference between poverty and non-poverty sample (T test)

Headcount

0.1316***

0.1298***

0.1092***

0.0943***

0.0780***

Mean positive overshoot

0.0612***

0.0483***

0.0363***

0.0262***

0.0176***

Note: ***implies significance at 0.001.


Determinants of CHE Incidence

Table 3 provides logistic regression results by using WHO indicator. It’s worth noting that whether there were children ≤ 5 in the household had no significant impact on CHE of rural impoverished households. Moreover, there was no significant correlation between household per-capita income and CHE among rural impoverished households, the increase of income couldn’t reduce CHE. While for rural non-poor households, those with lower level of per capita income were more likely to face higher risk of CHE (OR = 0.657***; P < 0.001). As for education background, there showed no significant correlation between household heads’ educational level and CHE among rural poor households. Logically, CHE incidence of rural poor households was significantly higher in areas with lower security level of medical insurance, but our results didn’t show the increase of per-capita security level of URRMI could reduce CHE incidence.

In addition, our results indicate there was significant correlation between household size and CHE among rural impoverished households, the increase of family member could reduce CHE (OR = 0.810***; P < 0.001). Whether there were older adults ≥ 65 in the household also had significant impact on CHE of rural impoverished households as well (OR = 1.643***; P < 0.001). In comparison with rural poor households without older adults ≥ 65, the CHE incidence of those with older adults ≥ 65 increased by 64.3%. More importantly, households with disabled members were significantly more likely to incur CHE (OR = 1.275**; P < 0.01). Both rural poor and non-poor households with chronic patient members were more vulnerable to a higher CHE incidence (OR = 1.496***; P < 0.001; OR = 1.740***; P < 0.001). Compared with rural poor households without disabled or chronic patient members, CHE incidence of those with disabled or chronically ill members increased significantly by 27.5% and 49.6%, and the average intensity increased by 0.014 and 0.027 respectively. Households with members who went to hospitals for outpatient care services during the past month or inpatient care services during the past year were much more vulnerable to CHE (OR = 1.460***; P < 0.001; OR = 2.198***; P < 0.001).

Table 3

Association between Factors and CHE in Rural Poor and Non-poor Households

Characteristics

Incidence of CHE(logit)

Intensity of CHE(tobit)

Poor

Non-poor

Poor

Non-poor

Model 1

Model 2

Model 3

Model 4

Fixed Effects

       

Intercept

0.282**

11.989***

-0.254**

0.441**

Household variables

       

Household size

0.810***

0.771***

-0.013***

-0.009***

Household with children ≤ 5

1.007

1.052

-0.001

0.005

Household with older adults ≥ 65

1.643***

1.903***

0.031***

0.024***

Household with disabled member

1.275**

1.167

0.014*

0.006

Household with chronically-ill member

1.496***

1.740***

0.027***

0.018***

Per capita income

1.026

0.657***

0.001

-0.018***

Outpatient Utilization Status

1.460***

1.442**

0.019**

0.010**

Inpatient Utilization Status

2.198***

3.100***

0.049***

0.040***

Educational level of household head

0.959

0.947

-0.003

-0.002

Region variable

       

Per capita security level of URRMI

0.725

0.494

-0.017

-0.012

Random Effects

       

Intercept variance

0.066

0.033

0.003

0.001

Level 1 variance

3.290

3.290

0.138

0.126

-2LL

3756.63

3493.08

2977.18

2667.88

N

3408

4253

3408

4253

Note: * p < 0.05, ** p < 0.01, *** p < 0.001.


Income-related inequality of CHE

Taking into account of the opportunity cost differences between the poor and the rich, we measured income-related inequality of CHE. With higher threshold level from 20–60%, CHE incidence and intensity tended to decrease. The results in Table 5 indicated that rural poor households were much more vulnerable to CHE. More importantly, given a fixed threshold level, rural poor households were more likely to experience CHE than non-poor ones.

Table 4

Concentration Indexes of CHE in Poor and Non-poor Households

 

Catastrophic threshold

20%

30%

40%

50%

60%

Total sample

         

Incidence

-0.1050

-0.1394

-0.1548

-0.1782

-0.2035

Intensity

-0.1663

-0.1857

-0.2028

-0.2232

-0.2461

Rural poor sample

         

Incidence

0.0163

0.0123

0.0018

-0.0151

-0.0204

Intensity

-0.0074

-0.0150

-0.0240

-0.0336

-0.0411

Rural non-poor sample

         

Incidence

-0.0939

-0.1310

-0.1390

-0.1461

-0.1820

Intensity

-0.1382

-0.1518

-0.1583

-0.1686

-0.1778

Note: * p < 0.05, ** p < 0.01, *** p < 0.001


Decomposition of CHE inequality in rural poor households

In Table 5, the majority of the observed inequalities in CHE incidence of rural impoverished households can be attributed to household per capita income (53.50%), having older adults ≥ 65 (28.73%)and inpatient utilization status of household members (8.87%). The total contribution percentage was 100%.

In Table 6, the main positive contribution to inequality in intensity in rural impoverished households was associated with household per capita income (57.16%), having older adults ≥ 65 (26.63%), inpatient utilization status of household members (8.15%). The total contribution percentage was also 100%. Some inpatient and outpatient services played a positive role in CHE inequality, which indicated that healthcare service utilization aggravated CHE inequality among rural impoverished households [36].

Table 5

Decomposition of Concentration Index of CHE Incidence (at a non-food expenditure threshold of 40%)

Characteristics

Elasticity

Concentration index (CI)

Contribution to CI

Contribution to CI %

Household variables

       

Household size

-0.4066

-0.0061

0.0025

-0.0230

Household with children ≤ 5

0.0047

-0.1369

-0.0006

0.0060

Household with older adults ≥ 65

0.2079

-0.1489

-0.0310

0.2873

Household with disabled member

0.0294

-0.0878

-0.0026

0.0240

Household with chronically-ill member

0.1934

-0.0005

-0.0001

0.0009

Per capita income

-0.5336

0.1080

-0.0576

0.5350

Outpatient Utilization Status

0.0421

-0.0347

-0.0015

0.0135

Inpatient Utilization Status

0.1086

-0.0880

-0.0096

0.0887

Educational level of household head

-0.0783

0.0817

-0.0064

0.0594

Region variable

       

Per capita security level of URRMI

-0.2370

0.0038

-0.0009

0.0083


Table 6

Decomposition of Concentration Index of Intensity (at a non-food expenditure threshold of 40%)

Characteristics

Elasticity

Concentration index (CI)

Contribution to CI

Contribution to CI %

Household variables

       

Household size

-0.5020

-0.0061

0.0031

-0.0212

Household with children ≤ 5

0.0067

-0.1369

-0.0009

0.0064

Household with older adults ≥ 65

0.2583

-0.1489

-0.0385

0.2663

Household with disabled member

0.0373

-0.0878

-0.0033

0.0227

Household with chronically-ill member

0.2392

-0.0005

-0.0001

0.0008

Per capita income

-0.7642

0.1080

-0.0825

0.5716

Outpatient Utilization Status

0.0416

-0.0347

-0.0014

0.0100

Inpatient Utilization Status

0.1338

-0.0880

-0.0118

0.0815

Educational level of household head

-0.0990

0.0817

-0.0081

0.0560

Region variable

       

Per capita security level of URRMI

-0.2281

0.0038

-0.0009

0.0060

Discussion

The urban-rural dual economic and social structure in China cannot be ignored. The relatively low income and lack of health care resources in rural regions make rural poor residents more vulnerable to the risk of CHE. This study used a national data from CHARLES to analyze extent, determinant factors and inequality of CHE among poor households. To the best of our knowledge, it is the first study to focus on these vulnerable groups and fulfills a research gap on Chinese rural poor households.

Previous studies have shown that the proportion of rural households incurring CHE (26.44%) was still considerably higher than that of urban households (12.6%) [26]. By applying WHO method, our results showed that CHE incidence and intensity of rural poor households in China were 28.20% and 0.076 respectively, much higher than those of non-poor households (17.28%, 0.039). The difference means that there was inequity between rural impoverished households and non-impoverished ones in terms of medical insurance risk sharing mechanism and healthcare services, OOP of poor households is still high.

Reducing risk of CHE and breaking vicious cycle between poverty and poor health are original intentions of medical security system design in China [37]. In this study, our findings found that, although existing health insurance schemes did provide certain financial protection for rural impoverished households, this protection was insufficient to some extent. In China, URRMI failed to effectively reduce the risk of CHE incurring in these poor households. As demonstrated in earlier studies, their results have also shown that the health insurance system didn’t play an effective role in mitigating the risk of CHE [38]. Therefore, for rural poor households, URRMI alone is not enough to effectively relieve poor households’ medical economy burden, multiple health insurance policies must work at the same time, such as medical assistance policies and major disease insurance scheme, thereby protecting these vulnerable groups from incurring CHE.

It is noteworthy that our study showed that households with children ≤ 5 were not at higher risk of CHE. Previous studies have shown that households with children ≤ 5 and older adults ≥ 65 tend to have higher incidence of CHE [28], while, some study implied that the impact of children ≤ 5 was not significant [17]. With the continuous progress of medical technology and the comprehensive development of China's children's disease prevention and healthcare work such as free vaccinations for newborns, the probability of children ≤ 5 suffering from major diseases is much lower, and the state also gives subsidies for treatment costs, which will greatly reduce medical economy burden of families. Moreover, previous study showed that there were some older adults in rural poor households who didn’t go to hospital for treatment due to economic reasons [29], which can avoid the occurrence of CHE. To some extent, our results implied that the above phenomena may exist, which needs to be taken into serious consideration by our policy-makers [39]. Interestingly, this study also revealed that per-capita income of households appeared to have no significant association on CHE of rural poor households. However, for non-impoverished households in rural regions, per-capita income was a significant factor associated with CHE.

In consistence with previous studies, large household size could protect rural poor households against CHE, and the probability of CEH risk would decrease as the number of family members increase [12]. Additionally, households with disabled members, chronically ill members were more likely to suffer from CHE, similar with other published studies [13]. The reason is that chronic diseases or disabilities not only limit a person's productive work ability, thus limiting household’s economic output, but also cause high medical expenditure [3941]. Therefore, expanding reimbursement catalogue of chronic diseases and disabilities in outpatient care services or enhancing reimbursement level of inpatient care services can play an effective role in protecting these vulnerable households from high OOP and financial health crisis [13].

This study also revealed that households with members who have sought for outpatient care services during the past month or inpatient care services during the past year were more vulnerable to a higher CHE incidence. Moreover, from a social welfare perspective, CHE were worse than it appeared by simply looking at part of the population that exceeds the threshold, because this overlooked the fact that the poor tend to exceed this threshold [28]. In addition, household having older adults ≥ 65 also significantly associated with CHE and was a major positive contributor to CHE inequality. Therefore, as China's aging population aggravates, the government must adjust healthcare policy concerned with older adults in order to decrease CHE inequality.

Some limitations of this study must be acknowledged. (1) 2018 CHARLS data used in the research is a cross-sectional data, which cannot analyze the dynamic changes of the determinant factors of CHE among rural impoverished households, nor solve the problem caused by possible missing variables. (2) Since there were rural residents not seeking for medical treatment due to insufficient income and lack of healthcare resources, CHE in rural impoverish households may be underestimated to a certain extent. (3) The measurement of OOP did not include indirect expenditure for seeking medical care such as income loss due to illness, accommodation and transportation, which may lead to underestimation of household healthcare expenditure and CHE incidence.

Conclusion

The relatively lower income level and lack of health care resources in rural China make impoverished households more vulnerable to the risk of CHE. Rural impoverished households are facing higher incidence of CHE (28.20%) and intensity (0.076). With little income left after necessary expenditure, it is highly possible for them to forgo needed health care, which raises an inequity question as to what happens to the poorest of the poor who are unable to afford health care. Moreover, determinants of CHE include household size, having older adults ≥ 65, having disabled members, having chronic patient members, having members seeking outpatient or inpatient service. There are also significant differences between the regression analysis of rural impoverished households and non-impoverished households, indicating inequity in CHE exists among them. Therefore, in order to reduce CHE incidence among rural impoverished households, solutions should not be limited to improving employment opportunities and public health care for the poor. The results of this study call for a more equitable, affordable and inclusive URRMI mechanism with expanding current benefits packages and increasing reimbursement level. Policy makers should also establish a new medical assistance system based on healthcare expenditure, which can effectively prevent CHE from occurring in rural impoverished households.

Declarations

Ethical approvalEthical approval for all the CHARLS waves was granted from the Institutional Review Board at Peking University. The IRB approval number for the main household survey, including anthropometrics, is IRB00001052-11015; the IRB approval number for biomarker collection, was IRB00001052-11014. During the fieldwork, each respondent who agreed to participate in the survey was asked to sign two copies of the informed consent, and one copy was kept in the CHARLS office, which was also scanned and saved in PDF format. Four separate consents were obtained: one for the main fieldwork, one for the non-blood biomarkers and one for the taking of the blood samples, and another for storage of blood for future analyses.

Consent for publication: Not applicable.

Availability of data and materials: The datasets generated and/or analysed during the current study are available in the [CHARLS] repository, [http://www. charls.pku.edu.cn]

Competing interests: The authors declare that they have no competing interests.

Funding: This research was funded by Ministry of Finance of the People's Republic of China (No. 2020K20071). The funding bodies were not involved in the design of the study, or data collection, analysis, and interpretation or in writing the manuscript.

Author contributions: Conceptualization, C.Z. and Y.W.; methodology, C.Z.; validation, C.Z., M.G. and Y.W.; formal analysis, C.Z. and Y.W.; investigation, C.Z. and Y.W.; data curation, C.Z.; writing—original draft preparation, C.Z. and Y.W.; writing—review and editing, C.Z., M.G. and Y.W.; supervision, M.G.; All authors read and approved the final manuscript.

Acknowledgments: We would like to acknowledge China Health and Retirement Longitudinal Study for their cooperation. We would also like to thank all study participants for their time to be interviewed.

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