. United Nations, Department of Economic and Social Affairs, Population Division. World Population Ageing 2019: Highlights. 2019. https://www.un.org/en/development/desa/population/publications/pdf/ageing/WorldPopulationAgeing2019-Highlights.pdf. Assessed 21 January 2020.
. Hales CM, Servais J, Martin CB, Kohen D. Prescription drug use among adults aged 40–79 in the United States and Canada. Centers for Disease Control and Prevention, National Center for Health Statistics. 2019. https://www.cdc.gov/nchs/data/databriefs/db347-h.pdf. Assessed 27 January 2020.
. Canadian Institute for Health Information. Drug Use Among Seniors in Canada, 2016. 2018. https://www.cihi.ca/sites/default/files/document/drug-use-among-seniors-2016-en-web.pdf. Assessed 30 May 2019.
. Yap AF, Thirumoorthy T, Kwan YH. Medication adherence in the elderly. Journal of Clinical Gerontology and Geriatrics. 2016;7(2):64-7.
. World Health Organization. Adherence to long-term therapies: Evidence for action. 2003. https://www.who.int/chp/knowledge/publications/adherence_report/en/
. Osterberg L, Blaschke T. Adherence to medication. New England Journal of Medicine. 2005;353(5):487-97.
. Coambs RB, Jensen P, Her MH, Ferguson BS, Jarry JL, Wong JS, Abrahamsohn RV. Review of the scientific literature on the prevalence, consequences, and health costs of noncompliance and inappropriate use of prescription medication in Canada. Ottawa: Pharmaceutical Manufacturers Association of Canada. 1995.
. DiMatteo MR. Variations in Patients' Adherence to Medical Recommendations: A Quantitative Review of 50 Years of Research. Medical care. 2004;42(3):200–9.
. Zelko E, Klemenc-Ketis Z, Tusek-Bunc K. Medication adherence in elderly with polypharmacy living at home: A systematic review of existing studies. Materia Sociomedica. 2016;28(2):129.
. George J, Elliott RA, Stewart DC. A systematic review of interventions to improve medication taking in elderly patients prescribed multiple medications. Drugs & aging. 2008;25(4):307-24.
. Granger BB, Bosworth H. Medication adherence: emerging use of technology. Current Opinion in Cardiology. 2011;26(4):279.
. Mistry N, Keepanasseril A, Wilczynski NL, Nieuwlaat R, Ravall M, Haynes RB, Patient Adherence Review Team. Technology-mediated interventions for enhancing medication adherence. Journal of the American Medical Informatics Association. 2015;22(e1):e177-93.
. Celler B, Argha A, Varnfield M, Jayasena R. Patient adherence to scheduled vital sign measurements during home telemonitoring: analysis of the intervention arm in a before and after trial. JMIR medical informatics. 2018;6(2):e15.
. Paré G, Moqadem K, Pineau G, St-Hilaire C. Clinical effects of home telemonitoring in the context of diabetes, asthma, heart failure and hypertension: a systematic review. Journal of medical Internet research. 2010;12(2):e21.
. Ahmad A, Chiu V, Arain MA. Users’ Perceptions of an in-Home Electronic Medication Dispensing System: A Qualitative Study. Medical Devices: Evidence and Research. 2020;13:31.
. Reeder B, Demiris G, Marek KD. Older adults' satisfaction with a medication dispensing device in home care. Informatics for Health and Social Care. 2013;38(3):211-22.
. Suzuki R, Hasegawa T. Evaluation of a one-dose package medication support system for community-based elderly patients and eldercare facilities. The Bulletin of the American Society of Hospital Pharmacists. 2018;75(9):e202-12.
. Rantanen P, Parkkari T, Leikola S, Airaksinen M, Lyles A. An in-home advanced robotic system to manage elderly home-care patients’ medications: A pilot safety and usability study. Clinical Therapeutics. 2017;39(5):1054-61.
. Allemann SS, Hersberger KE, Arnet I. Patient views on an electronic dispensing device for prepackaged polypharmacy: a qualitative assessment in an ambulatory setting. Integrated Pharmacy Research & Practice. 2015;4:167.
. Sibbald B, Roland M. Understanding controlled trials. Why are randomised controlled trials important?. BMJ: British Medical Journal. 1998;316(7126):201.
. Arain M, Campbell MJ, Cooper CL, Lancaster GA. What is a pilot or feasibility study? A review of current practice and editorial policy. BMC medical research methodology. 2010;10(1):1-7.
. Efird J. Blocked randomization with randomly selected block sizes. International journal of environmental research and public health. 2011;8(1):15-20.
. Sealed Envelope Ltd. Create a blocked randomisation list. 2019. https://www.sealedenvelope.com/simple-randomiser/v1/lists. Accessed 25 Feb 2019.
. CONSORT 2010. The CONSORT Statement. http://www.consort-statement.org/. Assessed 5 March 2020
. Catalyst HealthCare Ltd. AdhereNet: Pharmacy Software Platform. 2020. https://catalystrms.com/products/adherenet-pharmacy-software-platform.html. Accessed 14 April 2020.
. Harris PA, R Taylor, R Thielke, J Payne, N Gonzalez, JG. Conde, Research electronic data capture (REDCap) – A metadata-driven methodology and workflow process for providing translational research informatics support, J Biomed Inform. 2009;42(2):377-81.
. Harris PA, Taylor R, Minor BL, Elliott V, Fernandez M, O'Neal L, McLeod L, Delacqua G, Delacqua F, Kirby J, Duda SN. The REDCap consortium: Building an international community of software platform partners. Journal of biomedical informatics. 2019;95:103208.
. Lam WY, Fresco P. Medication adherence measures: an overview. BioMed research international. 2015. [https://doi.org/10.1155/2015/217047]
. McCoy CE. Understanding the intention-to-treat principle in randomized controlled trials. Western Journal of Emergency Medicine. 2017;18(6):1075-1078.
. Masnoon N, Shakib S, Kalisch-Ellett L, Caughey GE. What is polypharmacy? A systematic review of definitions. BMC geriatrics. 2017;17(1):230.
. Winland-Brown JE, Valiante J. Effectiveness of different medication management approaches on elders' medication adherence. Outcomes management for nursing practice. 2000;4(4):172-6.
. Buckwalter KC, Wakefield BJ, Hanna B, Lehmann J. New technology for medication adherence: electronically managed medication dispensing system. Journal of Gerontological Nursing. 2004;30(7):5-8.
. Kamimura T, Ishiwata R, Inoue T. Medication reminder device for the elderly patients with mild cognitive impairment. American Journal of Alzheimer's Disease & Other Dementias. 2012;27(4):238-42.
. Kamimura T. Older adults with Alzheimer’s disease who have used an automatic medication dispenser for 3 or more years. Clinical Gerontologist. 2019;42(1):127-33.
. CONSORT 2010. 15. Baseline Data. http://www.consort-statement.org/checklists/view/32--consort-2010/510-baseline-data. Assessed 20 February 2020
. Kwint HF, Stolk G, Faber A, Gussekloo J, & Bouvy ML. Medication adherence and knowledge of older patients with and without multidose drug dispensing. Age and ageing. 2013;42(5): 620-626.
. Lehane E, McCarthy G. Intentional and unintentional medication non-adherence: a comprehensive framework for clinical research and practice? A discussion paper. International journal of nursing studies. 2007:44(8):1468-1477.
. Nieuwlaat R, Wilczynski N, Navarro T, Hobson N, Jeffery R, Keepanasseril A, Agoritsas T, Mistry N, Iorio A, Jack S, Sivaramalingam B. Interventions for enhancing medication adherence. Cochrane database of systematic reviews. 2014(11).
. Higgins N, Regan C. A systematic review of the effectiveness of interventions to help older people adhere to medication regimes. Age and ageing. 2004;33(3):224-29.
. Marek KD, Stetzer F, Ryan PA, Bub LD, Adams SJ, Schlidt A, Lancaster R, O’Brien AM. Nurse care coordination and technology effects on health status of frail elderly via enhanced self-management of medication: Randomized clinical trial to test efficacy. Nursing Research. 2013;62(4):269.
. Gupta SK. Intention-to-treat concept: a review. Perspectives in clinical research. 2011;2(3):109.
. Kraemer HC, Mintz J, Noda A, Tinklenberg J, Yesavage JA. Caution regarding the use of pilot studies to guide power calculations for study proposals. Archives of general psychiatry. 2006 May 1;63(5):484-9.
. Leon AC, Davis LL, Kraemer HC. The role and interpretation of pilot studies in clinical research. Journal of psychiatric research. 2011;45(5):626-9.
. Col N, Fanale JE, Kronholm P. The role of medication noncompliance and adverse drug reactions in hospitalizations of the elderly. Archives of internal medicine. 1990;150(4):841-5.