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Research article
TAUSEEF AHMAD
School of Public Health, Southeast University, Nanjing, China
Corresponding Author
ORCiD: https://orcid.org/0000-0001-8793-273X
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background: Globally, tuberculosis (TB) remains the leading cause of death from a single infectious disease. TB treatment outcome is an indicator for the effectiveness of a national TB control program. This study aimed to assess treatment outcomes of TB patients and its determinants in Batkhela, Khyber Pakhtunkhwa, Pakistan. Methods: A retrospective cohort study was designed using all TB patients who were enrolled at District Head Quarter (DHQ) Hospital Batkhela, Pakistan, from January 2011 to December 2014. A binary logistic regression models were used to identify factors associated with successful TB treatment outcomes defined as the sum of cure and completed treatment. Results: A total of 515 TB patients were registered, of which 237 (46%) were males and 278 (53.98%) females. Of all patients, 234 (45.44%) were cured and 210 (40.77%) completed treatment. The overall treatment success rate was 444 (86.21%). Age 0-20 years (adjusted odds ratio, AOR= 3.47; 95% confidence interval, CI)= 1.54-7.81; P= 0.003), smear-positive pulmonary TB (AOR)= 3.58; 95% CI= 1.89-6.78; P= <0.001), treatment category (AOR= 4.71; 95% CI= 1.17-18.97; P= 0.029), and year of enrollment 2012 (AOR= 6.26; 95% CI= 2.52-15.59; P= <0.001) were significantly associated with successful treatment outcome. Conclusions: The overall treatment success rate is satisfactory but still need to be improved to achieve the international targeted treatment outcome. Type of TB, age, treatment category, and year of enrollment were significantly associated with successful treatment outcomes.
Keywords
Tuberculosis, Treatment outcome, Pakistan
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View the published article at BMC Infectious Diseases.
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Posted 17 Mar, 2020
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Editorial decision: Major revision
On 28 May, 2020
Review #1 received
Received 12 Mar, 2020
Editor assigned
On 11 Mar, 2020
Reviewers invited
Invitations sent on 11 Mar, 2020
Reviewer #1 agreed
On 11 Mar, 2020
Submission checks complete
On 10 Mar, 2020
Editor invited
On 10 Mar, 2020
No comments provided
Editorial decision: Major revision
On 12 Feb, 2020
Review #2 received
Received 29 Jan, 2020
Reviewer #2 agreed
On 28 Jan, 2020
Reviewer #1 agreed
On 23 Dec, 2019
Review #1 received
Received 23 Dec, 2019
Reviewers invited
Invitations sent on 18 Dec, 2019
Editor assigned
On 27 Nov, 2019
Submission checks complete
On 26 Nov, 2019
Editor invited
On 26 Nov, 2019
No comments provided
Editorial decision: Minor revision
On 11 Nov, 2019
Review #2 received
Received 03 Sep, 2019
Reviewer #2 agreed
On 28 May, 2019
Review #1 received
Received 07 May, 2019
Reviewer #1 agreed
On 06 May, 2019
Reviewers invited
Invitations sent on 05 May, 2019
Editor assigned
On 26 Apr, 2019
Submission checks complete
On 16 Apr, 2019
Editor invited
On 16 Apr, 2019
First submitted
On 14 Apr, 2019
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See the published version of this preprint at BMC Infectious Diseases.
This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research article
TAUSEEF AHMAD
School of Public Health, Southeast University, Nanjing, China
Corresponding Author
ORCiD: https://orcid.org/0000-0001-8793-273X
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Published
View the published article at BMC Infectious Diseases.
Version 3
Posted 17 Mar, 2020
No community comments so far
Editorial decision: Major revision
On 28 May, 2020
Review #1 received
Received 12 Mar, 2020
Editor assigned
On 11 Mar, 2020
Reviewers invited
Invitations sent on 11 Mar, 2020
Reviewer #1 agreed
On 11 Mar, 2020
Submission checks complete
On 10 Mar, 2020
Editor invited
On 10 Mar, 2020
No comments provided
Editorial decision: Major revision
On 12 Feb, 2020
Review #2 received
Received 29 Jan, 2020
Reviewer #2 agreed
On 28 Jan, 2020
Reviewer #1 agreed
On 23 Dec, 2019
Review #1 received
Received 23 Dec, 2019
Reviewers invited
Invitations sent on 18 Dec, 2019
Editor assigned
On 27 Nov, 2019
Submission checks complete
On 26 Nov, 2019
Editor invited
On 26 Nov, 2019
No comments provided
Editorial decision: Minor revision
On 11 Nov, 2019
Review #2 received
Received 03 Sep, 2019
Reviewer #2 agreed
On 28 May, 2019
Review #1 received
Received 07 May, 2019
Reviewer #1 agreed
On 06 May, 2019
Reviewers invited
Invitations sent on 05 May, 2019
Editor assigned
On 26 Apr, 2019
Submission checks complete
On 16 Apr, 2019
Editor invited
On 16 Apr, 2019
First submitted
On 14 Apr, 2019
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Internal Medicine Specialties
License:
This work is licensed under a CC BY 4.0 License. Read Full License
View the published article at BMC Infectious Diseases.
Background: Globally, tuberculosis (TB) remains the leading cause of death from a single infectious disease. TB treatment outcome is an indicator for the effectiveness of a national TB control program. This study aimed to assess treatment outcomes of TB patients and its determinants in Batkhela, Khyber Pakhtunkhwa, Pakistan. Methods: A retrospective cohort study was designed using all TB patients who were enrolled at District Head Quarter (DHQ) Hospital Batkhela, Pakistan, from January 2011 to December 2014. A binary logistic regression models were used to identify factors associated with successful TB treatment outcomes defined as the sum of cure and completed treatment. Results: A total of 515 TB patients were registered, of which 237 (46%) were males and 278 (53.98%) females. Of all patients, 234 (45.44%) were cured and 210 (40.77%) completed treatment. The overall treatment success rate was 444 (86.21%). Age 0-20 years (adjusted odds ratio, AOR= 3.47; 95% confidence interval, CI)= 1.54-7.81; P= 0.003), smear-positive pulmonary TB (AOR)= 3.58; 95% CI= 1.89-6.78; P= <0.001), treatment category (AOR= 4.71; 95% CI= 1.17-18.97; P= 0.029), and year of enrollment 2012 (AOR= 6.26; 95% CI= 2.52-15.59; P= <0.001) were significantly associated with successful treatment outcome. Conclusions: The overall treatment success rate is satisfactory but still need to be improved to achieve the international targeted treatment outcome. Type of TB, age, treatment category, and year of enrollment were significantly associated with successful treatment outcomes.
Figure 1
This is a list of supplementary files associated with this preprint. Click to download.
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