Background: Primary apocrine sweat gland adenocarcinoma is a very rare tumor. Apocrine carcinoma is a high incidence of local recurrence and lymph node metastasis. When the location of the tumor is axilla, it should be differentiated from occult breast cancer. Surgery is the first step in primary apocrine cancer treatment. However, there is no clear consensus about adjuvant part of treatment. In this case, we presented a 60-year old female patient with primary apocrine sweat gland carcinoma of the axilla. To our knowledge, this is the first case in the literature to use combined adjuvant radiation therapy and anti-estrogen therapy.
Case presentation: A 60-year old female patient presented with a slowly growing mass in the right axilla. The patient was examined by a surgeon and there was suspected to be metastasis from breast cancer diagnosed in September 2017. Axillary localized apocrine carcinoma was differentiated from occult breast cancer by pathological findings. For this reason, the patient was operated only an axillary dissection operation. Operated patient with axillary apocrine carcinoma was treated with radiotherapy. As a result of pathological evaluation of the tumor, tamoxifen was added to the treatment when the hormone receptor was positive.
Conclusions: The pathological features must be evaluated in detail for targeted treatment, which should be ap-plied with a multidisciplinary approach. Based on this case presentation and literature, adjuvant radiotherapy can be recommended to reduce the risk of local recurrence and hormone-therapy to reduce distant recurrence in patients with hormone-receptor positive primary apocrine carcinoma.