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Research article
The relationship between metabolic syndrome and increased risk of Barrett's esophagus: An Updated systematic review and meta-analysis
Milad Azami
Ilam University of Medical Sciences
Corresponding Author
ORCiD: https://orcid.org/0000-0002-4509-5520
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This work is licensed under a CC BY 4.0 License. Read Full License
Background: The relationship between metabolic syndrome ( MetS) and Barrett's esophagus (BE) is still a challenging issue, and inconsistent results have been reported in different studies. Therefore, this study was conducted to determine the relationship between MetS and BE.
Methods : In this study, we followed the MOOSE protocol and the PRISMA guidelines for reporting the results. All study steps were performed independently by two authors. If necessary, the dispute was resolved by consultation with a third author. The search strategy is designed to find published studies. Comprehensive search was done in the following biomedical databases until July 2019: Cochrane Library, PubMed/Medline, Web of Science, Science Direct, EMBASE, Scopus, CINAHL, EBSCO, and Google Scholar search engine. All analyses were performed using Comprehensive Meta-Analysis Software Ver.2, while p-value lower than 0.05 was considered significant.
Results : In 14 studies with a sample size of 108416, MetS significantly increased the risk of BE (OR=1.315; 95% CI: 1.110-1.558; P<0.001; Heterogeneity: I 2 = 81.55; P<0.001). Sensitivity analysis by omitting one study showed that overall estimates are still robust. Subgroup analysis was significant for continent (P<0.001) and MetS diagnostic criteria (P=0.043), but was not significant for variables of study type (P=0.899), study setting (P=0.115), control groups (P=0.671) and quality of studies (P=0.603). The Begg (P=0.912) and Egger's (P=0.094) tests were not significant; therefore, the publication bias did not play a role in the results.
Conclusion: MetS increases the risk of BE compared to control groups. Future studies should examine whether treatment for metabolic syndrome reduces the risk of BE.
Keywords
Metabolic Syndrome, Barrett's Esophagus, Meta-Analysis
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CURRENT STATUS: Under Review
Version 2
Posted 10 Jan, 2020
No community comments so far
Review #1 received
Received 05 Feb, 2020
Reviewer #1 agreed
On 22 Jan, 2020
Reviewers invited
Invitations sent on 17 Jan, 2020
Editor assigned
On 07 Jan, 2020
Submission checks complete
On 06 Jan, 2020
Editor invited
On 06 Jan, 2020
No comments provided
Editorial decision: Major revision
On 03 Nov, 2019
Review #2 received
Received 02 Nov, 2019
Review #1 received
Received 30 Oct, 2019
Reviewer #2 agreed
On 15 Oct, 2019
Reviewer #1 agreed
On 14 Oct, 2019
Reviewers invited
Invitations sent on 12 Oct, 2019
Editor assigned
On 25 Sep, 2019
Submission checks complete
On 24 Sep, 2019
Editor invited
On 24 Sep, 2019
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Subject Areas
Gastroenterology & Hepatology
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This preprint is under consideration at BMC Gastroenterology. A preprint is a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research article
The relationship between metabolic syndrome and increased risk of Barrett's esophagus: An Updated systematic review and meta-analysis
Milad Azami
Ilam University of Medical Sciences
Corresponding Author
ORCiD: https://orcid.org/0000-0002-4509-5520
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Under Review
Version 2
Posted 10 Jan, 2020
No community comments so far
Review #1 received
Received 05 Feb, 2020
Reviewer #1 agreed
On 22 Jan, 2020
Reviewers invited
Invitations sent on 17 Jan, 2020
Editor assigned
On 07 Jan, 2020
Submission checks complete
On 06 Jan, 2020
Editor invited
On 06 Jan, 2020
No comments provided
Editorial decision: Major revision
On 03 Nov, 2019
Review #2 received
Received 02 Nov, 2019
Review #1 received
Received 30 Oct, 2019
Reviewer #2 agreed
On 15 Oct, 2019
Reviewer #1 agreed
On 14 Oct, 2019
Reviewers invited
Invitations sent on 12 Oct, 2019
Editor assigned
On 25 Sep, 2019
Submission checks complete
On 24 Sep, 2019
Editor invited
On 24 Sep, 2019
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Gastroenterology & Hepatology
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background: The relationship between metabolic syndrome ( MetS) and Barrett's esophagus (BE) is still a challenging issue, and inconsistent results have been reported in different studies. Therefore, this study was conducted to determine the relationship between MetS and BE.
Methods : In this study, we followed the MOOSE protocol and the PRISMA guidelines for reporting the results. All study steps were performed independently by two authors. If necessary, the dispute was resolved by consultation with a third author. The search strategy is designed to find published studies. Comprehensive search was done in the following biomedical databases until July 2019: Cochrane Library, PubMed/Medline, Web of Science, Science Direct, EMBASE, Scopus, CINAHL, EBSCO, and Google Scholar search engine. All analyses were performed using Comprehensive Meta-Analysis Software Ver.2, while p-value lower than 0.05 was considered significant.
Results : In 14 studies with a sample size of 108416, MetS significantly increased the risk of BE (OR=1.315; 95% CI: 1.110-1.558; P<0.001; Heterogeneity: I 2 = 81.55; P<0.001). Sensitivity analysis by omitting one study showed that overall estimates are still robust. Subgroup analysis was significant for continent (P<0.001) and MetS diagnostic criteria (P=0.043), but was not significant for variables of study type (P=0.899), study setting (P=0.115), control groups (P=0.671) and quality of studies (P=0.603). The Begg (P=0.912) and Egger's (P=0.094) tests were not significant; therefore, the publication bias did not play a role in the results.
Conclusion: MetS increases the risk of BE compared to control groups. Future studies should examine whether treatment for metabolic syndrome reduces the risk of BE.
Figure 1
Figure 2
Figure 3
Figure 4
Figure 5