Background Hypertension is one of the chronic diseases with major health problems over the centuries due to its significant contribution to the global health burden. It is familiar that the hypertensive patients are also exposed to other diseases like diabetes in which the two are highly associated to each other. The objective of current investigation was to identify longitudinal predictors of hypertension and type2 diabetes for adult patients receiving treatments at Felege Hiwot Teaching and Specialized Hospital, North western Ethiopia.Methods In this study, 748 hypertensive and type2 diabetic adult patients were randomly selected using systematic sampling technique. A retrospective longitudinal study was conducted on the selected patients to identify predictors of hypertension and type2 diabetes. Patients were receiving treatments related to both hypertension and type2 diabetes.Results The current investigation revealed that age and weight of patients were positively and significantly associated with existence of hypertension and type2 diabetes whereas; visiting times were negatively associated with development of the two response variables. Rural patients, patients who are smoking, drinking alcohols and patients with family disease history were joint predictors for existence variables of interests. The interaction of visiting times * sex, visiting times *residence area and age *sex of patients were also significant factors for the existence of response variables.Conclusion Hypertensive patients living in rural areas and those who are drinking and smoking were highly affected by the existence of type2 diabetes. Awareness should be created to those hypertensive and type2 diabetic patients to attend properly their treatment as prescribed by the health staff. They should also be advised to checkup their hypertension (systolic/ diastolic) and diabetes of type2 regularly.