This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Research
Elio Castagnola
Istituto Giannina Gaslini
Corresponding Author
ORCiD: https://orcid.org/0000-0002-5336-8429
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background: knowledge on antibiotic susceptibility of S.aureus strains isolated from skin lesions in pediatric Italian patients is limited.
Methods: retrospective analysis of antibiotic susceptibility of S.aureus strains isolated from skin infections observed from January 2013 to June 2019 at the IRCCS Istituto Giannina Gaslini, Genoa – Italy
Results: a total of 1833 strains were analyzed. Methicillin resistance was more frequent in cultures from outpatients than from inpatients (18% vs. 14%, p=0.04) as well as resistance to cotrimoxazole (8% vs. 4.1%, p<0.001) Resistance to ampicillin was 99% in both groups, while to clindamycin it was 11% and 14%, respectively. Among topical antibiotics fusidic acid showed the better resistance profile (3%).
Conclusions: the proportion of antibiotic resistance in S.aureus skin infections in Italian children is not negligible. This could represent a problem, especially for orally administered drugs.
Keywords
Staphylococcus aureus, antibiotic resistance, skin infection, pediatrics, topical antibiotics
Loading...
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
History
CURRENT STATUS: Posted
View the published article at Journal of Chemotherapy.
Version 1
Posted 17 Sep, 2020
No community comments so far
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Pediatrics
Learn more about our company.
This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Research
Elio Castagnola
Istituto Giannina Gaslini
Corresponding Author
ORCiD: https://orcid.org/0000-0002-5336-8429
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
History
CURRENT STATUS: Posted
View the published article at Journal of Chemotherapy.
Version 1
Posted 17 Sep, 2020
No community comments so far
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Pediatrics
License:
This work is licensed under a CC BY 4.0 License. Read Full License
View the published article at Journal of Chemotherapy.
Background: knowledge on antibiotic susceptibility of S.aureus strains isolated from skin lesions in pediatric Italian patients is limited.
Methods: retrospective analysis of antibiotic susceptibility of S.aureus strains isolated from skin infections observed from January 2013 to June 2019 at the IRCCS Istituto Giannina Gaslini, Genoa – Italy
Results: a total of 1833 strains were analyzed. Methicillin resistance was more frequent in cultures from outpatients than from inpatients (18% vs. 14%, p=0.04) as well as resistance to cotrimoxazole (8% vs. 4.1%, p<0.001) Resistance to ampicillin was 99% in both groups, while to clindamycin it was 11% and 14%, respectively. Among topical antibiotics fusidic acid showed the better resistance profile (3%).
Conclusions: the proportion of antibiotic resistance in S.aureus skin infections in Italian children is not negligible. This could represent a problem, especially for orally administered drugs.
Loading...