Humans make eye-contact to extract information about other people’s mental states, recruiting dedicated brain networks that process information about the self and others. Recent studies show that eye-contact increases the synchronization between two brains. We investigated how eye-contact affects the frequency and direction of the synchronization within and between brains and the characteristics of the dual brain network (i.e. hyperbrain). Eye-contact was associated with higher coherence in the gamma frequency band (30-45Hz) for between and within brain connections. Network analysis revealed that some brain areas served as hubs which linked within- and between- brain networks (midparietal, midfrontal and right parietal areas). Friends showed more efficient eye-contact hyperbrain networks than strangers. During eye-contact, some dyads spontaneously adopted leader/follower roles, resulting in an increase in synchronization from leader to follower (interbrain) in the alpha frequency band. Eye-contact affected directed and undirected synchronization between brains more than within brains, offering support to the interactive brain hypothesis.