The Impact Factor of Colon Polyp

Objective: To evaluate the relationship between Helicobacter pylori and colonic polyp. Methods: The clinical data of 850 patients who underwent both colonoscopy and Helicobacter pylori check were collected in our hospital from January 2018 year to January 2019 year. Patients were divided into polyp group and control group. To analyze the helicobacter pylori infection of two groups, and the relationship among helicobacter pylori infection, eradication treatment and recurrence of colonic polyp. Further to analyze the impact factor of the recurrence of colonic polyp. Results: There were no signicant difference in sex and age aspects of two groups. Through SPSS software analysis, the infection rate of helicobater pylori was higher in polyp group than in control group. The recurrence rate of helicobacter pylori positive patients were more higher than helicobacter pylori negative patients. The recurrence rate of helicobacter pylori eradication group was lower than helicobacter pylori no eradication group. the impact factor of the recurrence of colonic polyp include helicobacter pylori infection, pathological type of polyp and the number of polyps. Conclusion: The helicobacter pylori infection rate of colonic polyp group were more higher. The impact factor of colonic polyp recurrence include helicobacter pylori infection, pathological types of polyp and polyp number.


Background
The polyp of large intestine is a kind of common digestive tract lesion,and a mass formed by the proliferation of the large intestine mucosa into the intestinal cavity.Pathologically, it can be divided into proliferative polyp, in ammatory polyp, adenomatous polyp, hamartoma polyp and so on.Hyperplastic polyps and in ammatory polyps generally have no cancerous tendency, adenomatous polyps and hamartomatous polyps have certain cancerous tendency.Rencently,the incidence of colorectal cancer have decreased due to increased precancerous lesion screening and resection of early colorectal lesions [1,2].The incidence of colorectal cancer is related to diet structure, environmental changes, genetic factors, oncogene imbalance and other factors, and there is no de nite and effective prevention method at present.Helicobacter pylori is a class of gram-negative microaerobic bacteria.Helicobacter pylori is associated with peptic diseases such as gastritis and peptic ulcer. It is the rst carcinogen of gastric cancer.In addition, Helicobacter pylori is also associated with iron de ciency anemia, idiopathic thrombocytopenic purpura, diabetes and other extragastric diseases.Studies have shown that Helicobacter pylori is associated with the risk of colorectal polyps [3,4].
In this study,through compared helicobacter pylori infection of large intestine polyp group with control group,and compared helicobacter pylori infection of different pathological types of polyp and control group,we analyze the relationship between helicobacter pylori and polyp of large intestine.  5. All patients were followed up for one year.

Statistical analysis:
Data collected were analysed using SPSS17.0. The measurement data use t test.The count data use chisquare test. P<0.05 was statistically signi cant.

Patient's clinical data:
We collected the clinical data of 850 patients who underwent both colonoscopy and Helicobacter pylori in endoscopic room of our hospital from January 2018 year to January 2019 year.Among these patients,there were 420 males,430 females.304 patients were helicobacter pylori positive,and 546 patients were helicobacter pylori negative. Among helicobacter pylori positive patients,there were 162 patients have helicobacter pylori eradicated,and 142 patients have not eradicated. In control group,there were 213 patients who's age over 60 years,and 202 patients who's age less than 60 years. In polyp group,there were 220 patients who's age over 60 years,and 215 patients who's age less than 60 years. In Table 1,there were no signi cant difference in sex and age aspects of two groups.  Through SPSS software analysis,the recurrence rate of helicobacter pylori positive patients were more higher than helicobacter pylori negative patients. The recurrence rate of helicobacter pylori eradication group was lower than helicobacter pylori no eradication group,and there was signi cant difference.The results shown in Table 3. Through SPSS software analysis,the impact factor of the recurrence of colonic polyp include helicobacter pylori infection,pathological type of polyp and the number of polyps.There was signi cant difference.The recurrence rate of helicobacter pylori positive,adenomatous polyps and multiple polyps were more higher.
The results were shown in Table 4. Table 4 The impact factor of the recurrence of colonic polyp.

Discussion
With the popularization of colonoscopy,the detection rate of colorectal polyps increased gradually. The colonic polyps are precancerous lesions of colon carcinoma. The canceration rate of colonic polyps range from 1.4-9.2% [5]. More than 80% of colonic cancers developed from colonic adenomas. The colonic adenomas have cancerous tendency. The incidence of colonic cancer decreased more than 75% after adenomatous polyp resection [6]. Research shows that helicobacter pylori infection have relationship with the development of colonic polyp [7,8].
The infection rate of helicobacter pylori in polyp group was higher in this study. The positive rate of helicobacter pylori was 44.1% in polyp group,and 36.9% in control group,there was signi cant difference between polyp group and control group. Reseach shows that helicobacter pylori infection have relationship with the recurrence of colonic polyp [9,10]. Helicobacter pylori eradication signi cantly reduces the risk of colonic polyp recurrence. This study found that the impact factor of colonic polyp recurrence include helicobacter pylori infection,pathological types of polyp and polyp number. The colonic polyp recurrence rate of helicobacter pylori positive patients was 66.4%,the helicobacter pylori negative patients was 33.9%,in ammation polyp was 38%,hyperplasia polyp was 40.5%, adenoma polyp was 48.4%,single polyp was 40.4%,and multiple polyp was 58.7%. The recurrence rate of colonic polyp were more higher in helicobacter pylori positive,adenoma polyp and multiple polyp group. In addition,the helicobacter pylori eradication therapy drugs include amoxicillin, clarithromycin,proton pump inhibitor and colloidal bismmth pectin in our study [11]. Compared with helicobacter pylori no eradication group,the recurrence rate of helicobacter pylori eradication group was 31.6%, helicobacter pylori no eradication group was 40.1%. It is indicated that the recurrence rate of helicobacter pylori eradication group was more lower than helicobacter pylori no eradication group. This shows that helicobacter pylori eradication can signi cantly decrease the recurrent risk of colonic polyp,which indicated that helicobacter pylori eradication may be the effective approache to prevent the recurrence of colonic polyp [12,13].
Conclusion: The helicobacter pylori infection rate of colonic polyp group were more higher.The impact factor of colonic polyp recurrence include helicobacter pylori infection,pathological types of polyp and polyp number. The recurrence rate of colon polyp were more higher in helicobacter pylori positive,adenoma polyp and multiple polyp group. Therefore, endoscopic treatment in time and helicobacter pylori eradication can decrease the recurrent risk of colon polyp.

Declarations
Ethics approval and consent to participate: The clinical research was established, according to the ethical guidelines of the Helsinki Declaration and was approved by the Human Ethics Committee of Xuancheng People's Hospital. Written informed consent was obtained from individual or guardian participants.

Consent for publication:
Not applicable.