China repond quickly to explosure of Covid-19. This paper aims to evaluate the impact of lockdown on 5 major airborne pollutant in Shanghai. Chongming, Xuhui and Jinshan areas of Shanghai were studied and compared. Overall, the Covid-19 lockdown has changed pollutant concentration in both long and short terms. All the five concentrations except for O3 increased. SO2 had significant correlations with all other pollutants. Ozone on eath surface are mainly from green plants and can be reduced by both NO2 and some organic matters. PM2.5 nd PM10 are more external than local procuced. NO2, SO2 and PM matters sharply reduced in Jinshan and Xuhui during dued to the limited usage of fossil fuel. All these activies could both meet humen’s neccesary needs and keep a better air quality. Proper and systematic measures should be taken to in keeping better air quality and economic growth in the whole world.