Background: High survival rate of children diagnosed with cancer has led to a growing population of women with premature ovarian failure (POF) due to chemotherapy and radiotherapy. The POF process occurs due to the disruption of the Hypothalamic-Pituitary and gonadal axis followed by the delay of puberty development. Evaluation of reproductive function in children with cancer is essential to determine the fertility preservation plan. This study aimed to describe reproductive function in children and adolescents with cancer who received chemotherapy based on Tanner stage evaluation, menstrual cycle, and Anti-Mullerian Hormone (AMH) examination using Electrochemilumiscence Immunoassay (ECLIA) Kit.
Result: Twenty-three girls aged 12-18 years old and had menarche who underwent cancer therapy in January-August 2019 in Dr. Sardjito General Hospital were included in the study. Among them, 61% girls had low AMH levels and were defined as Diminished Ovarian Reserve (DOR). There were two subjects with DOR who experienced delayed puberty. Regular menstrual cycle was reported in 65.2% subjects, while 21.7% encountered secondary amenorrhea.
Conclusion: Chemotherapy exposure impacted on DOR occurrence in 60.9% childhood and adolescence cancer. Moreover, it also altered menstrual regularity in 34.8% and delayed on puberty development in 8.7% subjects.