Introduction: In 2019, a viral and respiratory pathology called COVID-19 emerged in Wuhan, China and spread to other continents. Its main symptoms include fever, cough, dyspnea, myalgia, anorexia and respiratory distress in the most severe cases, which can lead to death. Furthermore, manifestations in the oral cavity such as ageusia and dysgeusia, as well as lesions in other regions of the oral cavity, can be observed.
Objective: Are Photobiomodulation (PBM) and Antimicrobial Photodynamic Therapy (aPDT) effective to treat oral manifestations of patients infected with SARS-CoV-2?
Methodology: It was defined following the PRISMA guidelines (Preferred Report on Systematic Reviews and Meta-Analysis), and registered in the database in the International Prospective Registry of Systematic Reviews (PROSPERO), including articles published between December 2019 to May 2021, Independent reviewers selected studies, qualitatively extracted data, assessed risk of bias using the Joanna Briggs Institute, assessed certainty of evidence through meta-analysis.
Results: Of the 5,959 articles found, 32 fit the types of studies, but only 5 of them attended the pre-established criteria. Data corresponding to the articles, protocols used and clinical outcome were extracted, then submitted to qualitative and descriptive analysis. The results show favoring the associated use of PBMT with aPDT (p=0.004), and the isolated use of PBMT with the result of significant “p=0.005” and good confidence interval (7.18, 39.20) in ulcerative lesions, herpetic, aphthous, erythematous, petechiae and necrotic areas.
Conclusion: According to the articles included in this review, PBMT and aPDT were effective in the treatment of oral lesions of patients infected with COVID-19 in a short period of time.